Opportunities to Target the Life Cycle of Epstein-Barr Virus (EBV) in EBV-Associated Lymphoproliferative Disorders

Opportunities to Target the Life Cycle of Epstein-Barr Virus (EBV) in EBV-Associated Lymphoproliferative Disorders is …
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scholarly articleQ13442814

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P356DOI10.3389/FONC.2019.00127
P932PMC publication ID6428703
P698PubMed publication ID30931253

P50authorBradley M HaverkosQ87988147
P2093author name stringCarrie B Coleman
James P Dugan
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Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus-encoded latent membrane protein 1 coregulates interleukin-6 and interleukin-8 productionQ40951743
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The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain.Q41371042
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Chemotherapy induces lytic EBV replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors.Q43931328
The EBNA-3 gene family proteins disrupt the G2/M checkpointQ44036145
Successful treatment of posttransplantation lymphoproliferative disorder (PTLD) following renal allografting is associated with sustained CD8(+) T-cell restorationQ44142809
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Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors.Q44790655
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Epstein-Barr Virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphomaQ45722302
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Effect of n-butyrate on cellular and viral DNA synthesis in cells latently infected with Epstein-Barr virusQ45802693
Effects of n-Butyrate and phorbol ester (TPA) on induction of Epstein-Barr virus antigens and cell differentiationQ45807559
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Replication of Epstein-Barr virus within the epithelial cells of oral "hairy" leukoplakia, an AIDS-associated lesionQ45837679
The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa BQ45876441
Direct BRLF1 binding is required for cooperative BZLF1/BRLF1 activation of the Epstein-Barr virus early promoter, BMRF1.Q34981036
An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinkingQ35000168
Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr virus latent membrane proteinsQ35068768
The role of promoter methylation in Epstein-Barr virus (EBV) microRNA expression in EBV-infected B cell lines.Q35171856
bZIP proteins of human gammaherpesviruses.Q35179637
Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4.Q35539925
Expression of viral microRNAs in Epstein-Barr virus-associated gastric carcinomaQ35634894
Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasionQ35652539
Persistence of the Epstein-Barr virus and the origins of associated lymphomasQ35715171
Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agentsQ35733719
Methylation status of the Epstein-Barr virus major latent promoter C in iatrogenic B cell lymphoproliferative disease. Application of PCR-based analysis.Q35787708
Epstein-barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinomaQ35788760
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Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapyQ35875897
The role of miRNAs and EBV BARTs in NPC.Q35924359
Epstein-Barr virus oncoprotein super-enhancers control B cell growthQ35963272
Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transferQ36059593
Hypermethylation of the tumor suppressor gene PRDM1/Blimp-1 supports a pathogenetic role in EBV-positive Burkitt lymphomaQ36065290
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Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic miceQ36327458
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EBV LMP2A affects LMP1-mediated NF-kappaB signaling and survival of lymphoma cells by regulating TRAF2 expressionQ36508964
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Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoterQ37156071
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Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancersQ37362803
Higher methylation intensity induced by EBV LMP1 via NF-κB/DNMT3b signaling contributes to silencing of PTEN geneQ37457770
Epigenetic regulation of latent Epstein-Barr virus promotersQ37620765
Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytesQ37707304
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The EBNA3 Family: Two Oncoproteins and a Tumour Suppressor that Are Central to the Biology of EBV in B CellsQ38597236
Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expressionQ38728190
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Epstein-Barr virus-encoded small non-coding RNAs induce cancer cell chemoresistance and migrationQ39136769
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The proto-oncogene c-myc is a direct target gene of Epstein-Barr virus nuclear antigen 2.Q39551287
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Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcriptionQ39594681
Differential methylation of Epstein-Barr virus latency promoters facilitates viral persistence in healthy seropositive individuals.Q39596964
Variant chromatin structure of the oriP region of Epstein-Barr virus and regulation of EBER1 expression by upstream sequences and oriP.Q39603362
The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's LymphomaQ39606643
The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral productionQ39735571
Nucleosome assembly proteins bind to Epstein-Barr virus nuclear antigen 1 and affect its functions in DNA replication and transcriptional activationQ39804470
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectlymphoproliferative disordersQ4165484
Epstein–Barr virusQ6900
P304page(s)127
P577publication date2019-01-01
P1433published inFrontiers in OncologyQ26839986
P1476titleOpportunities to Target the Life Cycle of Epstein-Barr Virus (EBV) in EBV-Associated Lymphoproliferative Disorders
P478volume9

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cites work (P2860)
Q99211990Enhancing antitumor immunity through checkpoint blockade as a therapeutic strategy in T-cell lymphomas
Q92541244The Function and Therapeutic Potential of Epstein-Barr Virus-Encoded MicroRNAs in Cancer

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