Population Heterogeneity in Mutation Rate Increases the Frequency of Higher-Order Mutants and Reduces Long-Term Mutational Load.

scientific article published on 11 November 2016

Population Heterogeneity in Mutation Rate Increases the Frequency of Higher-Order Mutants and Reduces Long-Term Mutational Load. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/MOLBEV/MSW244
P932PMC publication ID5850754
P698PubMed publication ID27836985

P50authorSebastian BonhoefferQ28914704
Helen K AlexanderQ80448534
P2093author name stringStephanie I Mayer
P2860cites workTwo genetic hits (more or less) to cancerQ22251289
Rates of spontaneous mutationQ24548000
Viral mutation ratesQ24611162
The rate of establishment of complex adaptationsQ24619467
Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesisQ24625342
Mutation rates among RNA virusesQ24643023
Genetic instabilities in human cancersQ28131826
Evolution of mutation rates in bacteriaQ28238561
Antibiotic treatment enhances the genome-wide mutation rate of target cellsQ28386555
Spontaneous emergence of multiple drug resistance in tuberculosis before and during therapyQ28477566
Adaptation from standing genetic variationQ29614722
Rates of evolutionary change in viruses: patterns and determinantsQ29616174
Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptaseQ29619994
Influence of reverse transcriptase variants, drugs, and Vpr on human immunodeficiency virus type 1 mutant frequenciesQ30453160
Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coliQ33373675
Determining mutation rates in bacterial populationsQ33803752
Significance of multiple mutations in cancerQ33846180
Drug resistance in cancer: principles of emergence and preventionQ33892278
The cost of replication fidelity in an RNA virusQ33900476
The evolution of mutation rates: separating causes from consequencesQ33925698
Clusters of mutations from transient hypermutabilityQ33943859
Mutation frequency and biological cost of antibiotic resistance in Helicobacter pyloriQ33952076
The mutational load with epistatic gene interactions in fitnessQ33983691
Evolutionary dynamics of carcinogenesis and why targeted therapy does not work.Q34005286
Mutator clones of Neisseria meningitidis in epidemic serogroup A diseaseQ34028018
Theoretical analysis of mutation hotspots and their DNA sequence context specificityQ34218124
A mutator phenotype in cancer.Q34222899
The evolution of stress-induced hypermutation in asexual populationsQ34285727
Multiple mutations and cancerQ34327554
The speed of evolution and maintenance of variation in asexual populationsQ34330675
Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populationsQ34358875
Evolution of high mutation rates in experimental populations of E. coliQ34429727
High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection.Q34508854
Production of resistant HIV mutants during antiretroviral therapyQ35165357
Volatility of Mutator Phenotypes at Single Cell ResolutionQ35600360
Proliferation of mutators in A cell populationQ35618973
Phasing of single DNA molecules by massively parallel barcodingQ35657501
Evolutionary significance of stress-induced mutagenesis in bacteriaQ35785631
Mutation as a stress response and the regulation of evolvabilityQ35869358
Outwitting evolution: fighting drug-resistant TB, malaria, and HIV.Q35878689
Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing.Q36339832
Estimating the per-base-pair mutation rate in the yeast Saccharomyces cerevisiaeQ36391958
Too many mutants with multiple mutationsQ36491712
Pervasive multinucleotide mutational events in eukaryotesQ36553453
Seeing mutations in living cellsQ36730530
Polymorphic mutation frequencies in Escherichia coli: emergence of weak mutators in clinical isolatesQ37007127
Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencingQ37083023
Mutator phenotype may be required for multistage carcinogenesisQ37732904
Ultra-deep sequencing for the analysis of viral populationsQ37996203
The frequency of mutators in populations of Escherichia coliQ38304923
Dissecting cancer evolution at the macro-heterogeneity and micro-heterogeneity scale.Q38305991
The balance between mutators and nonmutators in asexual populationsQ38517985
Mutation rate plasticity in rifampicin resistance depends on Escherichia coli cell-cell interactions.Q39145276
High frequency of mutator strains among human uropathogenic Escherichia coli isolates.Q39694657
Frequency of mutation to rifampin resistance in Streptococcus pneumoniae clinical strains: hexA and hexB polymorphisms do not account for hypermutation.Q39743496
Errors in DNA replication as a basis of malignant changesQ39870986
Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variationQ40023839
Heterogeneity of the mutation rates of influenza A viruses: isolation of mutator mutantsQ40308879
Single-Cell Analysis of RNA Virus Infection Identifies Multiple Genetically Diverse Viral Genomes within Single Infectious UnitsQ40951839
Translational errors as the cause of mutations in Escherichia coliQ41112840
Monotonicity of fitness landscapes and mutation rate control.Q41445226
Mutation and cancer: the antecedents to our studies of adaptive mutation.Q41749616
Interrelationship between HIV-1 fitness and mutation rate.Q41888126
Transient mutators: a semiquantitative analysis of the influence of translation and transcription errors on mutation ratesQ41999710
Measurement of SOS expression in individual Escherichia coli K-12 cells using fluorescence microscopyQ42468116
Virus mutators and antimutators: roles in evolution, pathogenesis and emergenceQ43514301
High Rate of Macrolide Resistance inStaphylococcus aureusStrains from Patients with Cystic Fibrosis Reveals High Proportions of Hypermutable StrainsQ44195004
Stress-induced mutagenesis in bacteriaQ44459277
Hypermutable Haemophilus influenzae with mutations in mutS are found in cystic fibrosis sputumQ45044337
Effect of subinhibitory concentrations of ciprofloxacin on Mycobacterium fortuitum mutation ratesQ46546957
Spontaneous mutators in bacteria: insights into pathways of mutagenesis and repairQ46617407
Spontaneous multiple mutations show both proximal spacing consistent with chronocoordinate events and alterations with p53-deficiencyQ47629045
High mutation frequencies among Escherichia coli and Salmonella pathogensQ48057867
Stress-induced mutagenesis and complex adaptation.Q51052567
Promotion of evolution by intracellular coexistence of mutator and normal DNA polymerases.Q52061092
Role of mutator alleles in adaptive evolution.Q54564129
Highly Variable Mutation Rates in Commensal and Pathogenic Escherichia coliQ56944671
Evidence for a High Frequency of Simultaneous Double-Nucleotide SubstitutionsQ57162931
The accumulation of deleterious genes in a population--Muller's RatchetQ67444775
Promotion of evolution: disparity in the frequency of strand-specific misreading between the lagging and leading DNA strands enhances disproportionate accumulation of mutationsQ67581927
General antimutators are improbableQ70532050
The approach to mutation-selection balance in an infinite asexual population, and the evolution of mutation ratesQ73373285
Evaluating evolutionary models of stress-induced mutagenesis in bacteriaQ86095467
P433issue2
P304page(s)419-436
P577publication date2017-02-01
P1433published inMolecular Biology and EvolutionQ1992656
P1476titlePopulation Heterogeneity in Mutation Rate Increases the Frequency of Higher-Order Mutants and Reduces Long-Term Mutational Load
P478volume34

Reverse relations

cites work (P2860)
Q90505681Bacterial phenotypic heterogeneity in DNA repair and mutagenesis
Q92556450Chemosensation and Evolution of Drosophila Host Plant Selection
Q55162233Death and population dynamics affect mutation rate estimates and evolvability under stress in bacteria.
Q64955796Gene Expression Noise Produces Cell-to-Cell Heterogeneity in Eukaryotic Homologous Recombination Rate.
Q55258904Heterogeneity of spontaneous DNA replication errors in single isogenic Escherichia coli cells.
Q58997159Opposing effects of final population density and stress on Escherichia coli mutation rate
Q89241069Real-time dynamics of mutagenesis reveal the chronology of DNA repair and damage tolerance responses in single cells
Q40072185Spontaneous mutation rate is a plastic trait associated with population density across domains of life
Q58785293Why are RNA virus mutation rates so damn high?

Search more.