ERADication of EDEM1 occurs by selective autophagy and requires deglycosylation by cytoplasmic peptide N-glycanase.

scientific article published on 25 March 2014

ERADication of EDEM1 occurs by selective autophagy and requires deglycosylation by cytoplasmic peptide N-glycanase. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00418-014-1204-3
P698PubMed publication ID24664425

P50authorJin Won ChoQ12617092
Yukishige ItoQ37376248
P2093author name stringChristian Zuber
Jürgen Roth
Ichiro Matsuo
Yangsin Lee
Insook Jang
Sujin Park
P2860cites workp62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagyQ24300134
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranesQ24300526
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stressQ24301895
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein AlfyQ24307759
p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteinsQ24311839
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagyQ24312147
Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycansQ24313146
A role for NBR1 in autophagosomal degradation of ubiquitinated substratesQ24316135
HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtinQ24337155
EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complexQ24338144
A novel ER alpha-mannosidase-like protein accelerates ER-associated degradationQ24522524
A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromisedQ24535941
Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradationQ24555191
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
Misfolded proteins partition between two distinct quality control compartmentsQ24651093
EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sitesQ24683239
Structural basis for sorting mechanism of p62 in selective autophagyQ27650745
Autophagy fights disease through cellular self-digestionQ27860902
A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradationQ27930372
Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumenQ27930448
Defining the glycan destruction signal for endoplasmic reticulum-associated degradationQ27932810
A complex of Pdi1p and the mannosidase Htm1p initiates clearance of unfolded glycoproteins from the endoplasmic reticulumQ27933028
Yos9p detects and targets misfolded glycoproteins for ER-associated degradationQ27933494
Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD.Q27934679
Mnl1p, an alpha -mannosidase-like protein in yeast Saccharomyces cerevisiae, is required for endoplasmic reticulum-associated degradation of glycoproteinsQ27937049
Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structureQ27938571
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1pQ27938951
Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulumQ27939524
Htm1p, a mannosidase-like protein, is involved in glycoprotein degradation in yeastQ27939809
Aggresomes: a cellular response to misfolded proteinsQ28292275
A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradationQ28296585
Selective autophagy mediated by autophagic adapter proteinsQ28301940
EDEM1 accelerates the trimming of alpha1,2-linked mannose on the C branch of N-glycansQ28510507
Immunolocalization of UDP-glucose:glycoprotein glucosyltransferase indicates involvement of pre-Golgi intermediates in protein quality controlQ28582340
Autophagy: renovation of cells and tissuesQ29547206
Methods in mammalian autophagy researchQ29547276
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell deathQ29547297
The role of Atg proteins in autophagosome formationQ29547418
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cellsQ29614181
Intracellular Aspects of the Process of Protein SynthesisQ29615237
Roles of N-linked glycans in the endoplasmic reticulumQ29616458
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagyQ30014829
Role of the SEL1L:LC3-I complex as an ERAD tuning receptor in the mammalian ER.Q44455557
Misfolding of glycoproteins is a prerequisite for peptide: N-glycanase mediated deglycosylation.Q45238415
Systematic synthesis and inhibitory activity of haloacetamidyl oligosaccharide derivatives toward cytoplasmic peptide:N-glycanaseQ46434284
Use of poly(vinylpyrrolidone) and poly(vinyl alcohol) for cryoultramicrotomyQ46472458
Chemistry and biology of wortmanninQ46511165
z-VAD-fmk inhibits peptide:N-glycanase and may result in ER stressQ46589271
A cell culture system for the induction of Mallory bodies: Mallory bodies and aggresomes represent different types of inclusion bodiesQ47973741
A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.Q52931787
Large protein complexes retained in the ER are dislocated by non-COPII vesicles and degraded by selective autophagy.Q54455138
Prevention of non-specific interactions of gold-labeled reagents on tissue sectionsQ69094922
Postembedding labeling on Lowicryl K4M tissue sections: detection and modification of cellular componentsQ69536946
Ubiquitylation in the ERAD PathwayQ83165590
The ubiquitin clan: A protein family essential for lifeQ84828995
A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteinsQ31130967
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinaseQ33796255
Delivery of ubiquitinated substrates to protein-unfolding machinesQ33989072
ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagyQ33998133
A role for N-glycanase in the cytosolic turnover of glycoproteinsQ34179944
Ultrastructural localization of intracellular antigens by the use of protein A-gold complexQ34186780
The structure and biological features of fibrinogen and fibrin.Q34311771
Identification and distribution of peptide:N-glycanase (PNGase) in mouse organsQ34313410
Identification of peptide:N-glycanase activity in mammalian-derived cultured cellsQ34352953
Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxinQ34584029
Golgi apparatus immunolocalization of endomannosidase suggests post-endoplasmic reticulum glucose trimming: implications for quality controlQ34783037
Characterization of early EDEM1 protein maturation events and their functional implicationsQ35107478
Rad23 and Rpn10: perennial wallflowers join the meleeQ35950681
The Png1-Rad23 complex regulates glycoprotein turnoverQ36116808
Immunolocalization of the oligosaccharide trimming enzyme glucosidase IIQ36215161
The organization of endoplasmic reticulum export complexesQ36237498
Cytoplasmic peptide:N-glycanase and catabolic pathway for free N-glycans in the cytosolQ36976680
Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligaseQ37260547
The proteostasis boundary in misfolding diseases of membrane trafficQ37587095
Autophagy and misfolded proteins in neurodegenerationQ37811463
Mitochondria removal by autophagyQ37831014
Protein N-glycosylation, protein folding, and protein quality control.Q37845738
Protein folding and modification in the mammalian endoplasmic reticulum.Q37865523
Fluorescently labeled inhibitor for profiling cytoplasmic peptide:N-glycanaseQ38299876
Rad23 provides a link between the Png1 deglycosylating enzyme and the 26 S proteasome in yeast.Q38303135
p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrateQ39504135
A reporter cell system to monitor autophagy based on p62/SQSTM1.Q39688848
Basal autophagy is involved in the degradation of the ERAD component EDEM1.Q39876239
Segregation and rapid turnover of EDEM1 by an autophagy-like mechanism modulates standard ERAD and folding activitiesQ39985945
EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.Q40229528
Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover.Q40478768
p62 Is a common component of cytoplasmic inclusions in protein aggregation diseasesQ42184099
Inhibition of human caspases by peptide-based and macromolecular inhibitorsQ42538024
Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinaseQ42799184
Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies.Q42917978
P433issue2
P921main subjectautophagyQ288322
P304page(s)153-169
P577publication date2014-03-25
P1433published inHistochemistry and Cell BiologyQ1524012
P1476titleERADication of EDEM1 occurs by selective autophagy and requires deglycosylation by cytoplasmic peptide N-glycanase
P478volume142

Reverse relations

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