The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ.

scientific article published on 21 November 2016

The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1044774201
P356DOI10.1038/SREP37276
P8608Fatcat IDrelease_4cosfzepuffv7o2ehrkmqghlnu
P932PMC publication ID5116678
P698PubMed publication ID27869138

P50authorMiguel A PinedaQ84449877
P2093author name stringLamyaa Al-Riyami
Margaret M Harnett
William Harnett
David T Rodgers
Kara S Bell
Christina N Steiger
Fraser A Marshall
Russell J Eason
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From the worm to the pill, the parasitic worm product ES-62 raises new horizons in the treatment of rheumatoid arthritis.Q35584865
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The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62.Q36276216
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The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthmaQ36499489
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Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo.Q52583019
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Phosphorylcholine mimics the effects of ES-62 on macrophages and dendritic cells.Q54559083
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A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cellsQ73869188
The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sitesQ84449879
Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62Q84957045
The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotypeQ36644781
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ES-62 protects against collagen-induced arthritis by resetting interleukin-22 toward resolution of inflammation in the jointsQ41845753
Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints.Q41968548
C9orf72 is required for proper macrophage and microglial function in miceQ42364302
Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitroQ43237166
Mast Cell Subsets and Their Functional Modulation by the Acanthocheilonema viteae Product ES-62.Q43240017
Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responsesQ43479791
NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase Cdelta. Correlation to nuclear Ikappa BalphaQ43556697
Critical role of protein kinase C epsilon for lipopolysaccharide-induced IL-12 synthesis in monocyte-derived dendritic cellsQ44183336
Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62.Q44268237
PKCδ regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasisQ44430636
Hyporesponsiveness of murine B lymphocytes exposed to the filarial nematode secreted product ES-62 in vivoQ44447965
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
dendritic cellQ506253
P304page(s)37276
P577publication date2016-11-21
P1433published inScientific ReportsQ2261792
P1476titleThe helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ.
P478volume6

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cites work (P2860)
Q64921466Anti-inflammatory Trained Immunity Mediated by Helminth Products Attenuates the Induction of T Cell-Mediated Autoimmune Disease.
Q36368300Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62.
Q58546956Failure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease
Q39244181From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home.
Q58122562Immunomodulation by Helminths: Intracellular Pathways and Extracellular Vesicles
Q48120789Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling
Q48145971TLR Specific Immune Responses against Helminth Infections
Q64063577filaria activates human dendritic cells and polarizes T helper 1 and regulatory T cells via toll-like receptor 4

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