Failure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease

scientific article published on 17 October 2018

Failure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/MOLECULES23102669
P932PMC publication ID6222842
P698PubMed publication ID30336585

P50authorAnne CookeQ86427000
Hui-Rong JiangQ92389625
James DoonanQ41687173
P2093author name stringDavid Thomas
Colin J Suckling
Kathrin S Michelsen
Lamyaa Al-Riyami
Margaret M Harnett
William Harnett
Karen J Fairlie-Clarke
Felicity E Lumb
Hazel J Ramage
Kara S Bell
Michelle H Wong
P2860cites workExpansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infectionQ28305927
Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitisQ28591514
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Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cellsQ29614271
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Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disordersQ33719638
Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy propertiesQ33994121
Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis.Q34016661
Secreted proteins from the helminth Fasciola hepatica inhibit the initiation of autoreactive T cell responses and prevent diabetes in the NOD mouseQ34400239
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Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammationQ35230822
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The parasitic worm product ES-62 targets myeloid differentiation factor 88-dependent effector mechanisms to suppress antinuclear antibody production and proteinuria in MRL/lpr miceQ35538362
Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasomeQ35694891
Microbiota regulates type 1 diabetes through Toll-like receptorsQ35718048
Gut biogeography of the bacterial microbiotaQ35820919
Microbes and asthma: Opportunities for interventionQ35947135
The Gastrointestinal Tract Microbiota and Allergic DiseasesQ35974132
Testing small molecule analogues of the Acanthocheilonema viteae immunomodulator ES-62 against clinically relevant allergensQ35983932
The metabolic role of the gut microbiota in health and rheumatic disease: mechanisms and interventionsQ36038992
Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62.Q36368300
The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthmaQ36499489
The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotypeQ36644781
Hookworm excretory/secretory products induce interleukin-4 (IL-4)+ IL-10+ CD4+ T cell responses and suppress pathology in a mouse model of colitisQ36911496
TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.Q37019308
Heligmosomoides polygyrus bakeri infection activates colonic Foxp3+ T cells enhancing their capacity to prevent colitisQ37215636
Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10.Q37628188
Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue.Q50463855
Heligmosomoides polygyrus: EAE remission is correlated with different systemic cytokine profiles provoked by L4 and adult nematodes.Q51317590
Inhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+ regulatory T cells.Q51673568
Schistosoma mansoni egg antigens induce Treg that participate in diabetes prevention in NOD mice.Q51765576
Soluble egg antigen from Schistosoma japonicum modulates the progression of chronic progressive experimental autoimmune encephalomyelitis via Th2-shift response.Q53032691
Protection Against Arthritis by the Parasitic Worm Product ES-62, and Its Drug-Like Small Molecule Analogues, Is Associated With Inhibition of Osteoclastogenesis.Q54977322
Infection with a Helminth Parasite Attenuates Autoimmunity through TGF- -Mediated Suppression of Th17 and Th1 ResponsesQ59632270
Following a diabetogenic T cell from genesis through pathogenesisQ70488192
A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating diseaseQ84371124
The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sitesQ84449879
Initial gut microbiota structure affects sensitivity to DSS-induced colitis in a mouse modelQ88852812
ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae.Q38199606
Regulation of the host immune system by helminth parasitesQ38835948
Host-Microbiota Interactions Shape Local and Systemic Inflammatory DiseasesQ39077398
The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ.Q39169396
Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation.Q41360170
FoxP3+ T regulatory cells and immunomodulation after Schistosoma mansoni egg antigen immunization in experimental model of inflammatory bowel diseaseQ41433941
ES-62 protects against collagen-induced arthritis by resetting interleukin-22 toward resolution of inflammation in the jointsQ41845753
Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints.Q41968548
Mast Cell Subsets and Their Functional Modulation by the Acanthocheilonema viteae Product ES-62.Q43240017
Hyporesponsiveness of murine B lymphocytes exposed to the filarial nematode secreted product ES-62 in vivoQ44447965
Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetesQ44474619
Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signallingQ48120789
Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunizationQ48419105
Salmonella typhimurium infection halts development of type 1 diabetes in NOD miceQ50096775
The role of the gut microbiome in systemic inflammatory disease.Q50134012
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
type-1 diabetesQ124407
inflammatory bowel diseasesQ917447
P577publication date2018-10-17
P1433published inMoleculesQ151332
P1476titleFailure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease
P478volume23

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Q64073396The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritiscites workP2860

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