The viral oncogene Np9 acts as a critical molecular switch for co-activating β-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells

scientific article published on 11 January 2013

The viral oncogene Np9 acts as a critical molecular switch for co-activating β-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/LEU.2013.8
P698PubMed publication ID23307033
P5875ResearchGate publication ID234105115

P2093author name stringJ Tang
J Wu
L Huang
X Wang
X Zhang
W Huang
X Xu
Y Gu
T Chen
F Xu
H Zhou
G Xu
Y Fang
R Xu
S Zheng
Z Meng
Y Gan
J Jin
C Van Ness
X Gan
P2860cites workExpression of a human endogenous retrovirus, HERV-K, in the blood cells of leukemia patientsQ43882758
Comparative longitudinal studies of HERV-K and HIV-1 RNA titers in HIV-1-infected patients receiving successful versus unsuccessful highly active antiretroviral therapyQ44327519
beta-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemiaQ46345796
Initial sequencing and analysis of the human genomeQ21045365
Reconstitution of an infectious human endogenous retrovirusQ21559512
LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradationQ24536102
Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein XQ24562056
Regulation of myeloid leukaemia by the cell-fate determinant MusashiQ24634359
Identification of an infectious progenitor for the multiple-copy HERV-K human endogenous retroelementsQ24676640
Reconstitution of the ancestral glycoprotein of human endogenous retrovirus k and modulation of its functional activity by truncation of the cytoplasmic domainQ28749689
Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaQ29615115
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapiesQ29615606
Human endogenous retrovirus protein cORF supports cell transformation and associates with the promyelocytic leukemia zinc finger proteinQ33292072
Many human endogenous retrovirus K (HERV-K) proviruses are unique to humansQ33872725
Evidence for genomic rearrangements mediated by human endogenous retroviruses during primate evolutionQ34101407
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemiasQ34212654
Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cellsQ34253011
Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemiaQ34541588
Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulationQ34905557
The human T-cell leukemia virus type 1 oncoprotein tax controls forkhead box O4 activity through degradation by the proteasomeQ35077555
Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia.Q35144582
Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.Q35164266
Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumorsQ35742389
Human acute myeloid leukemias may be etiologically associated with new human retroviral infectionQ36808116
Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancerQ36898870
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Q37865381
Characterization of the human endogenous retrovirus K Gag protein: identification of protease cleavage sites.Q39572030
β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cellsQ39620290
Physical and functional interactions of human endogenous retrovirus proteins Np9 and rec with the promyelocytic leukemia zinc finger proteinQ40158980
Expression of human endogenous retrovirus K in melanomas and melanoma cell linesQ40421149
HERV-K: the biologically most active human endogenous retrovirus familyQ41106251
Human endogenous retrovirus HERV-K113 is capable of producing intact viral particlesQ42030768
Characterization of the intragenomic spread of the human endogenous retrovirus family HERV-W.Q42673218
P433issue7
P304page(s)1469-1478
P577publication date2013-01-11
P1433published inLeukemiaQ6534498
P1476titleThe viral oncogene Np9 acts as a critical molecular switch for co-activating β-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells
P478volume27

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cites work (P2860)
Q30842942"Reverse genomics" and human endogenous retroviruses
Q90415585Aberrant activation of RPB1 is critical for cell overgrowth in acute myeloid leukemia
Q37269175Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth
Q89702908Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines
Q36110284Chimeric antigen receptor T cells targeting HERV-K inhibit breast cancer and its metastasis through downregulation of Ras
Q58796885Disruption by SaCas9 Endonuclease of HERV-K, a Retroviral Gene with Oncogenic and Neuropathogenic Potential, Inhibits Molecules Involved in Cancer and Amyotrophic Lateral Sclerosis
Q34120178Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma.
Q28067477Endogenous retroviral promoter exaptation in human cancer
Q30234309Epigenetic Control of Human Endogenous Retrovirus Expression: Focus on Regulation of Long-Terminal Repeats (LTRs)
Q91671358Evaluating the expression level of HERV-K env, np9, rec and gag in breast tissue
Q37625774Expression of human endogenous retrovirus-K is strongly associated with the basal-like breast cancer phenotype.
Q35123776Expression-analysis of the human endogenous retrovirus HERV-K in human astrocytic tumors.
Q52338720HERV Envelope Proteins: Physiological Role and Pathogenic Potential in Cancer and Autoimmunity.
Q37186225HERV-K(HML-2), the Best Preserved Family of HERVs: Endogenization, Expression, and Implications in Health and Disease
Q52682321HERVs New Role in Cancer: From Accused Perpetrators to Cheerful Protectors.
Q92017208HIV-1 Rev interacts with HERV-K RcREs present in the human genome and promotes export of unspliced HERV-K proviral RNA
Q55711521Human Endogenous Retrovirus K in the Crosstalk Between Cancer Cells Microenvironment and Plasticity: A New Perspective for Combination Therapy.
Q90189900Human Endogenous Retroviruses (HERVs): Shaping the Innate Immune Response in Cancers
Q98612837Human Endogenous Retroviruses in Clear Cell Renal Cell Carcinoma: Biological Functions and Clinical Values
Q37539094Human Endogenous Retroviruses-K (HML-2) Expression Is Correlated with Prognosis and Progress of Hepatocellular Carcinoma.
Q27010373Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?
Q34091109Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients
Q57466814Human endogenous retrovirus-K (HML-2): a comprehensive review
Q92356863Identification of leukemia stem cell expression signatures through Monte Carlo feature selection strategy and support vector machine
Q38529916Molecular functions of human endogenous retroviruses in health and disease.
Q36186500Np9, a cellular protein of retroviral ancestry restricted to human, chimpanzee and gorilla, binds and regulates ubiquitin ligase MDM2.
Q34059199Regulation of the human endogenous retrovirus K (HML-2) transcriptome by the HIV-1 Tat protein
Q97681546Reply to Comment on "UGT2B17 modifies drug response in chronic lymphocytic leukaemia"
Q35957393Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner.
Q64070092Structural variation of centromeric endogenous retroviruses in human populations and their impact on cutaneous T-cell lymphoma, Sézary syndrome, and HIV infection
Q41933413Susceptibility of Human Endogenous Retrovirus Type-K to Reverse Transcriptase Inhibitors
Q64091828The HERV-K accessory protein Np9 controls viability and migration of teratocarcinoma cells
Q53089292The landscape of somatic mutations in Down syndrome-related myeloid disorders.
Q54216669Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development.
Q58803090Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

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