Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment.

scientific article

Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10545-012-9511-0
P698PubMed publication ID22767283

P50authorAndrey Y. AbramovQ48291443
P2093author name stringShamima Rahman
Iain P Hargreaves
Simon J Heales
Kate E C Duberley
Annapurna Chalasani
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Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ10 deficiencyQ37317328
PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell deathQ39873016
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Progression despite replacement of a myopathic form of coenzyme Q10 defectQ45028156
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Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration.Q48462986
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Determination of coenzyme Q10 status in blood mononuclear cells, skeletal muscle, and plasma by HPLC with di-propoxy-coenzyme Q10 as an internal standard.Q53647703
Coenzyme Q10-responsive ataxia: 2-year-treatment follow-upQ58184277
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Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian BrainsQ61714001
Mechanism of O2- generation in reduction and oxidation cycle of ubiquinones in a model of mitochondrial electron transport systemsQ69844120
Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondriaQ70080329
Mitochondrial respiratory chain defects are not accompanied by an increase in the activities of lactate dehydrogenase or manganese superoxide dismutase in paediatric skeletal muscle biopsiesQ73287564
Mitochondrial damage induced by conditions of oxidative stressQ77814514
Glutathione and glutathione-linked enzymes in normal human aortic smooth muscle cells: chemical inducibility and protection against reactive oxygen and nitrogen species-induced injuryQ79501744
P433issue1
P921main subjectpathogenesisQ372016
mitochondrionQ39572
4-aminobenzoic acidQ284959
ubidecarenoneQ321285
P304page(s)63-73
P577publication date2012-07-06
P1433published inJournal of Inherited Metabolic DiseaseQ6295359
P1476titleHuman neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment
P478volume36

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