Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma

scientific article

Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/2159-8290.CD-12-0028
P698PubMed publication ID22705984

P50authorChoon Kiat OngQ40793543
Bin Tean TehQ47451223
P2093author name stringPatrick Tan
Soo Yong Tan
Soon Thye Lim
Christopher Goh
Tiffany Tang
Kheng-Wei Yeoh
Ioana Cutcutache
Steve Rozen
George E Allen
Whee Sze Ong
Leonard Tan
Miriam Tao
Richard Quek
Susan Loong
Swee Peng Yap
Daryl Tan
Kevin Tay
Cedric Chuan Young Ng
Vikneswari Rajasegaran
Song Ling Poon
Lay Cheng Lim
Hong Lee Heng
Kuo Ann Lee
Ghee Chong Koo
Anna Gan
Willie Yu
Soo Ching Chong
P433issue7
P304page(s)591-597
P577publication date2012-06-15
P1433published inCancer DiscoveryQ15724440
P1476titleJanus kinase 3-activating mutations identified in natural killer/T-cell lymphoma
P478volume2

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cites work (P2860)
Q90812985A clinicohaematological prognostic model for nasal-type natural killer/T-cell lymphoma: A multicenter study
Q38724665A neutralized human LMP1-IgG inhibits ENKTL growth by suppressing the JAK3/STAT3 signaling pathway
Q43135354A unique case of refractory primary mediastinal B-cell lymphoma with JAK3 mutation and the role for targeted therapy
Q92262684Activated hippo signal pathway inhibits cell proliferation and promotes apoptosis in NK/T cell lymphoma cells
Q54342283Activated janus kinase 3 expression not by activating mutations identified in natural killer/T-cell lymphoma.
Q42827073Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells
Q33718415Adapter protein Shc regulates Janus kinase 3 phosphorylation
Q59793939Advances in multiple omics of natural-killer/T cell lymphoma
Q90482750Advances in targeted therapy for malignant lymphoma
Q47113632Advances in the understanding and management of T-cell prolymphocytic leukemia
Q52718168Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target.
Q43905021Allogeneic haematopoietic cell transplantation for extranodal natural killer/T-cell lymphoma, nasal type: a CIBMTR analysis
Q57216715Aspects moléculaires des lymphomes T périphériques (2)
Q41721837Association between extranodal natural killer/T-cell lymphoma and hepatitis B viral infection: a case-control study
Q40040761Beyond first-line non-anthracycline-based chemotherapy for extranodal NK/T-cell lymphoma: clinical outcome and current perspectives on salvage therapy for patients after first relapse and progression of disease
Q91187938Characteristic gene alterations in primary gastrointestinal T- and NK-cell lymphomas
Q40766488Coexistence of systemic lupus erythematosus, tuberous sclerosis and aggressive natural killer-cell leukaemia: coincidence or correlated?
Q35832062Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma
Q54982413Critically dysregulated signaling pathways and clinical utility of the pathway biomarkers in lymphoid malignancies.
Q30275203Cutaneous EBV-related lymphoproliferative disorders
Q38868306Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations
Q59359829Defining the elusive boundaries of chronic active Epstein-Barr virus infection
Q38763094Development of Selective Covalent Janus Kinase 3 Inhibitors.
Q30249309Diagnosis and management of extranodal NK/T cell lymphoma nasal type.
Q38201143Disease-specific mutations in mature lymphoid neoplasms: recent advances
Q39107367Downregulation of miR-15a due to LMP1 promotes cell proliferation and predicts poor prognosis in nasal NK/T-cell lymphoma
Q38761793EBV-negative aggressive NK-cell leukemia/lymphoma: a clinical and pathological study from a single institution
Q44028421Effect of Janus kinase 3 on the peptide transporters PEPT1 and PEPT2.
Q35132241Emerging therapeutic paradigms to target the dysregulated Janus kinase/signal transducer and activator of transcription pathway in hematological malignancies
Q90012509Epigenetic aberrations in natural killer/T-cell lymphoma: diagnostic, prognostic and therapeutic implications
Q64039644Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases
Q64269086Epstein-Barr Virus-Positive Natural Killer/T-Cell Lymphoma
Q56930876Epstein-Barr virus-associated lymphomas
Q45328020Epstein-Barr virus-negative extranodal "true" natural killer-cell lymphoma harbouring a KDM6A mutation.
Q44998179Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia
Q40717160Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
Q40101543Frequent BCOR aberrations in extranodal NK/T-Cell lymphoma, nasal type
Q38186617From empiric to mechanism-based therapy for peripheral T cell lymphoma.
Q39183278Genetic Landscape and Classification of Peripheral T Cell Lymphomas
Q36232164Genetic alterations of JAK/STAT cascade and histone modification in extranodal NK/T-cell lymphoma nasal type
Q40596015Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study.
Q92265373Genetic susceptibility to natural killer T-cell lymphoma
Q91136332Genomic analysis reveals recurrent deletion of JAK-STAT signaling inhibitors HNRNPK and SOCS1 in mycosis fungoides
Q90463789Genomic and transcriptomic landscapes of Epstein-Barr virus in extranodal natural killer T-cell lymphoma
Q39237403HiJAKing the epigenome in leukemia and lymphoma
Q89725109IL-9 and Th9 Cells in Tumor Immunity
Q33798544Identification of a novel functional JAK1 S646P mutation in acute lymphoblastic leukemia
Q34106849Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia
Q26782539JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indications
Q39142126JAK/STAT pathway directed therapy of T-cell leukemia/lymphoma: Inspired by functional and structural genomics
Q39149556JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.
Q64120387JAK3/STAT3 oncogenic pathway and PRDM1 expression stratify clinicopathologic features of extranodal NK/T‑cell lymphoma, nasal type
Q34321767JAKs and STATs in immunity, immunodeficiency, and cancer
Q58796912LEE011 and ruxolitinib: a synergistic drug combination for natural killer/T-cell lymphoma (NKTCL)
Q42330161MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia.
Q39064213Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming
Q57287731MiRNA-155 regulates lymphangiogenesis in natural killer/T-cell lymphoma by targeting BRG1
Q38191876Modes of infection and oncogenesis by the Epstein-Barr virus.
Q89304773Molecular Insights Into Pathogenesis of Peripheral T Cell Lymphoma: a Review
Q38597997Molecular Pathogenesis of Peripheral T Cell Lymphoma
Q64085662Molecular pathogenic pathways in extranodal NK/T cell lymphoma
Q37708936Molecular pathways: molecular basis for sensitivity and resistance to JAK kinase inhibitors.
Q47395580Mutant JAK3 signaling is increased by loss of wild type JAK3 or by acquiring secondary JAK3 mutations in T-ALL.
Q37324841Mutational Analysis of Extranodal NK/T-Cell Lymphoma Using Targeted Sequencing with a Comprehensive Cancer Panel
Q91855455Mutational profile and EBV strains of extranodal NK/T-cell lymphoma, nasal type in Latin America
Q37389358Mutations in the JAK/STAT and RAS signaling pathways are common in intestinal T-cell lymphomas
Q28540834NCI-60 whole exome sequencing and pharmacological CellMiner analyses
Q39263682New tumor entities in the 4th edition of the World Health Organization classification of head and neck tumors: Nasal cavity, paranasal sinuses and skull base.
Q47548002Novel findings from the Asian Lymphoma Study Group: focus on T and NK-cell lymphomas
Q90483988Oncogenic Network and Hub Genes for Natural Killer/T-Cell Lymphoma Utilizing WGCNA
Q55281964Oncogenic Signaling Pathways and Pathway-Based Therapeutic Biomarkers in Lymphoid Malignancies.
Q50055394Oncogenic activation of JAK3-STAT signaling confers clinical sensitivity to PRN371, a novel selective and potent JAK3 inhibitor, in natural killer/T-cell lymphoma
Q58742961Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma
Q64087879Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)
Q97645211Plasma circulating tumor DNA assessment reveals KMT2D as a potential poor prognostic factor in extranodal NK/T-cell lymphoma
Q36277681Primary CNS T-cell Lymphomas: A Clinical, Morphologic, Immunophenotypic, and Molecular Analysis
Q58690869Prognostic and therapeutic significance of phosphorylated STAT3 and protein tyrosine phosphatase-6 in peripheral-T cell lymphoma
Q87538001RHOA mutations in peripheral T cell lymphoma
Q36259257RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC.
Q44535044Rare occurrence of JAK3 mutations in natural killer cell neoplasms in Japan
Q47240802Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma
Q90134157Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma
Q52647036Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia.
Q89090594Refining pathological diagnoses in lymphoid malignancies
Q35067345Retrospective review using targeted deep sequencing reveals mutational differences between gastroesophageal junction and gastric carcinomas
Q59354279STAT3 is constitutively activated in chronic active Epstein-Barr virus infection and can be a therapeutic target
Q54959839STAT5 inhibition induces TRAIL/DR4 dependent apoptosis in peripheral T-cell lymphoma.
Q35145308Serum levels of interleukin-9 correlate with negative prognostic factors in extranodal NK/T-cell lymphoma
Q39063866T-Cell Lymphoma: Recent Advances in Characterization and New Opportunities for Treatment
Q34648812Targeting the JAK-STAT pathway in lymphoma: a focus on pacritinib
Q60019698The Genomics and Molecular Biology of Natural Killer/T-Cell Lymphoma: Opportunities for Translation
Q90260574The Role of Interleukin-9 in Cancer
Q39243241The diagnosis and management of NK/T-cell lymphomas.
Q47147269The effect of the JAK2 inhibitor TG101209 against T cell acute lymphoblastic leukemia (T-ALL) is mediated by inhibition of JAK-STAT signaling and activation of the crosstalk between apoptosis and autophagy signaling
Q38741546Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells
Q42378681Transforming Mutations of Jak3 (A573V and M511I) Show Differential Sensitivity to Selective Jak3 Inhibitors
Q37257158Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations
Q52899841Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Hematolymphoid Tumours.
Q27320602Using drug response data to identify molecular effectors, and molecular "omic" data to identify candidate drugs in cancer
Q38115228VIII. New markers in peripheral T-cell lymphomas: more entities or more confusion?
Q58695601Whole exome sequencing identifies recessive germline mutations in FAM160A1 in familial NK/T cell lymphoma
Q38705023Whole transcriptome analysis reveals dysregulated oncogenic lncRNAs in natural killer/T-cell lymphoma and establishes MIR155HG as a target of PRDM1.
Q35884253Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides
Q87195954[The progress of diagnostic and prognostic molecular markers of lymphoma]

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