Transforming Mutations of Jak3 (A573V and M511I) Show Differential Sensitivity to Selective Jak3 Inhibitors

scientific article published on January 2016

Transforming Mutations of Jak3 (A573V and M511I) Show Differential Sensitivity to Selective Jak3 Inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2174/2212697X03666160610085943
P932PMC publication ID5642970
P698PubMed publication ID29046866

P2093author name stringJeremy A Ross
Robert A Kirken
G Steven Martinez
P2860cites workJAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse modelQ28109595
Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathwaysQ33787804
Tofacitinib, an oral Janus kinase inhibitor, for the treatment of chronic plaque psoriasis: results from two randomized, placebo-controlled, phase III trialsQ34483765
Array-based genomic resequencing of human leukemiaQ34618836
Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignanciesQ35956625
Interleukin-2 Receptor β Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules.Q35978264
Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activityQ36498064
JAK mutations in high-risk childhood acute lymphoblastic leukemiaQ37224111
Inhibition of JAK3 with a novel, selective and orally active small molecule induces therapeutic response in T-cell malignanciesQ37695012
Recent progress and perspective in JAK inhibitors for rheumatoid arthritis: from bench to bedsideQ38543700
Janus kinase 3-activating mutations identified in natural killer/T-cell lymphomaQ39329997
Activating alleles of JAK3 in acute megakaryoblastic leukemiaQ40255542
The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicitiesQ40370385
Cancer incidence among Hispanic children in the United StatesQ40396503
Racial and ethnic differences in survival of children with acute lymphoblastic leukemiaQ40637235
Rising rates of acute lymphoblastic leukemia in Hispanic children: trends in incidence from 1992 to 2011.Q42564155
Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemiaQ44998179
SEER update of incidence and trends in pediatric malignancies: acute lymphoblastic leukemiaQ46333198
Trends in leukemia incidence and survival in the United States (1973–1998)Q50718276
Activated janus kinase 3 expression not by activating mutations identified in natural killer/T-cell lymphoma.Q54342283
Il-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo.Q54447711
JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adultsQ79657116
P433issue2
P304page(s)131-137
P577publication date2016-01-01
P1433published inClinical cancer drugsQ27727308
P1476titleTransforming Mutations of Jak3 (A573V and M511I) Show Differential Sensitivity to Selective Jak3 Inhibitors
P478volume3

Reverse relations

Q58742961Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphomacites workP2860

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