The Genomics and Molecular Biology of Natural Killer/T-Cell Lymphoma: Opportunities for Translation

scientific article published on 30 June 2018

The Genomics and Molecular Biology of Natural Killer/T-Cell Lymphoma: Opportunities for Translation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3390/IJMS19071931
P932PMC publication ID6073933
P698PubMed publication ID29966370

P50authorSiok-Bian NgQ60374588
P2093author name stringWee-Joo Chng
Anand D Jeyasekharan
Tae-Hoon Chung
Sanjay de Mel
Yingting Mok
Gwyneth Shook-Ting Soon
P2860cites workBCoR, a novel corepressor involved in BCL-6 repressionQ22254616
MicroRNAs: target recognition and regulatory functionsQ24609584
Widespread microRNA repression by Myc contributes to tumorigenesisQ24647067
Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathwayQ24657973
Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cellsQ26740953
Therapeutic options in peripheral T cell lymphomaQ26748857
Status of PI3K/Akt/mTOR pathway inhibitors in lymphomaQ27026544
OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumorsQ27728475
AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to TaxolQ27824792
Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingQ27860529
Human CD38: a glycoprotein in search of a functionQ28252788
Targeting CD38 with Daratumumab Monotherapy in Multiple MyelomaQ28266655
MLL targets SET domain methyltransferase activity to Hox gene promotersQ28609771
Targeting CD38 in Refractory Extranodal Natural Killer Cell-T-Cell LymphomaQ44552844
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunityQ45217684
p53, K-ras, c-kit and beta-catenin gene mutations in sinonasal NK/T-cell lymphoma in Korea and Japan.Q45219269
Epstein-Barr virus-mediated dysregulation of human microRNA expressionQ45388785
Low frequency of HLA-A*0201 allele in patients with Epstein-Barr virus-positive nasal lymphomas with polymorphic reticulosis morphologyQ45741924
Nasal lymphomas in Japan: a high prevalence of Epstein-Barr virus type A and deletion within the latent membrane protein geneQ45745453
Cytotoxic granular protein expression, Epstein-Barr virus strain type, and latent membrane protein-1 oncogene deletions in nasal T-lymphocyte/natural killer cell lymphomas from Mexico.Q45754031
Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphomaQ47240802
EBV-associated primary nodal T/NK-cell lymphoma shows distinct molecular signature and copy number changes.Q47447684
A major turning point in NK/T-cell lymphoma?Q48222546
Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiationQ49414498
Oncogenic activation of JAK3-STAT signaling confers clinical sensitivity to PRN371, a novel selective and potent JAK3 inhibitor, in natural killer/T-cell lymphoma.Q50055394
Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic γδ T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitroQ42815166
Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cellsQ42827073
Rare occurrence of JAK3 mutations in natural killer cell neoplasms in JapanQ44535044
Novel JAK3-Activating Mutations in Extranodal NK/T-Cell Lymphoma, Nasal Type.Q51101587
Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study.Q51403316
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.Q51732144
Hypermethylation of PRDM1/Blimp-1 promoter in extranodal NK/T-cell lymphoma, nasal type: an evidence of predominant role in its downregulation.Q52845594
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.Q53597468
Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: different genomic alteration patterns of aggressive NK-cell leukemia and extranodal Nk/T-cell lymphoma, nasal type.Q53664277
Frequent mutations of Fas gene in nasal NK/T cell lymphoma.Q53966209
Activated janus kinase 3 expression not by activating mutations identified in natural killer/T-cell lymphoma.Q54342283
The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancersQ56593831
Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of ChinaQ57214947
Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphomaQ58742961
Peripheral T-cell lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upQ61053530
Mutations of the p53 gene in nasal NK/T-cell lymphomaQ73711198
Comparative genomic hybridization study of nasal-type NK/T-cell lymphomaQ73774958
TET2 and DNMT3A mutations in human T-cell lymphomaQ83175924
Activated oncogenic pathways and therapeutic targets in extranodal nasal-type NK/T cell lymphoma revealed by gene expression profilingQ83367663
Lack of evidence that HACE1 is not a tumor suppressor gene in NKTCL: to the editor-in-chief. Authors' replyQ86967267
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitionsQ29614512
Role of platelet-derived growth factors in physiology and medicineQ29615222
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutationsQ29615392
p53 in health and diseaseQ29619939
Epigenetic inactivation of the miR-124-1 in haematological malignanciesQ31008825
P53, N- and K-Ras, and beta-catenin gene mutations and prognostic factors in nasal NK/T-cell lymphoma from Hokkaido, JapanQ31038356
MicroRNA profiling of Epstein-Barr virus-associated NK/T-cell lymphomas by deep sequencingQ31080906
Gene mutation analysis of sinonasal lymphomas in IndonesiaQ33238945
Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parametersQ33402136
Bevacizumab and cyclosphosphamide, doxorubicin, vincristine and prednisone in combination for patients with peripheral T-cell or natural killer cell neoplasms: an Eastern Cooperative Oncology Group study (E2404).Q33408536
Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profilingQ33566663
Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphomaQ33585243
Checkpoint inhibitors in hematological malignanciesQ33651495
Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal typeQ33677463
High-resolution genome-wide analysis identified recurrent genetic alterations in NK/T-cell lymphoma, nasal type, which are associated with disease progressionQ33839279
Outcomes of first-line treatment for chronic lymphocytic leukemia with 17p deletionQ33978930
The HLA system. First of two partsQ34023681
Epstein-Barr virus BART9 miRNA modulates LMP1 levels and affects growth rate of nasal NK T cell lymphomasQ34079271
Dysregulated microRNAs affect pathways and targets of biologic relevance in nasal-type natural killer/T-cell lymphomaQ34216713
Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cellsQ34544793
Prognostic implication of morphology, cyclinE2 and proliferation in EBV-associated T/NK lymphoproliferative disease in non-immunocompromised hostsQ34677558
TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κBQ34737822
Extranodal NK/T-cell lymphoma: toward the identification of clinical molecular targetsQ34898306
Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progressionQ34995467
Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr virus latent membrane proteinsQ35068768
p53 Mutations in nasal natural killer/T-cell lymphoma from Mexico: association with large cell morphology and advanced diseaseQ35747125
Comparative genomic hybridization analysis of natural killer cell lymphoma/leukemia. Recognition of consistent patterns of genetic alterationsQ35788068
Consistent patterns of allelic loss in natural killer cell lymphomaQ35829661
Global promoter methylation analysis reveals novel candidate tumor suppressor genes in natural killer cell lymphomaQ35859357
Quantitative comparison of immunohistochemical staining measured by digital image analysis versus pathologist visual scoringQ36048767
Genetic alterations of JAK/STAT cascade and histone modification in extranodal NK/T-cell lymphoma nasal typeQ36232164
RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC.Q36259257
HACE1 is a tumor suppressor gene candidate in natural killer cell neoplasmsQ36495194
Expression of microRNA-10a, microRNA-342-3p and their predicted target gene TIAM1 in extranodal NK/T-cell lymphoma, nasal typeQ36502791
MicroRNA function in NK-cell biologyQ36751927
The 2016 revision of the World Health Organization classification of lymphoid neoplasmsQ36920426
The universal character of the tumor-associated antigen survivinQ36975578
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLsQ37061865
Diagnostic and prognostic value of circulating miR-221 for extranodal natural killer/T-cell lymphomaQ37329665
PD-L1 is upregulated by EBV-driven LMP1 through NF-κB pathway and correlates with poor prognosis in natural killer/T-cell lymphomaQ37340738
Racial Patterns of Peripheral T-Cell Lymphoma Incidence and Survival in the United StatesQ37350788
Epstein-Barr virus in lymphoproliferative processes: an update for the diagnostic pathologist.Q37355565
STAT3 transcription factor is constitutively activated and is oncogenic in nasal-type NK/T-cell lymphomaQ37485330
The downregulation of PRDM1/Blimp-1 is associated with aberrant expression of miR-223 in extranodal NK/T-cell lymphoma, nasal typeQ37504355
MicroRNA regulation of natural killer cellsQ38085574
Molecular underpinning of extranodal NK/T-cell lymphomaQ38114561
The RUNX family: developmental regulators in cancerQ38319972
Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemiaQ38351879
Involvement of MicroRNA in T-Cell Differentiation and MalignancyQ38388753
Genomic signatures in T-cell lymphoma: How can these improve precision in diagnosis and inform prognosis?Q38576333
Comparison of Different Antibody Clones for Immunohistochemistry Detection of Programmed Cell Death Ligand 1 (PD-L1) on Non-Small Cell Lung CarcinomaQ38673895
EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphomaQ38764673
Receptor-type tyrosine-protein phosphatase κ directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphomaQ38917500
Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative disorder in children and young adults has similar molecular signature to extranodal nasal natural killer/T-cell lymphoma but shows distinctive stem cell-like phenotypeQ38941606
Molecular and Biochemical Aspects of the PD-1 Checkpoint PathwayQ38996832
JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.Q39149556
EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activityQ39175582
The diagnosis and management of NK/T-cell lymphomas.Q39243241
Janus kinase 3-activating mutations identified in natural killer/T-cell lymphomaQ39329997
Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analysesQ39521104
MicroRNA-146a downregulates NFκB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphomaQ39536983
The role of microRNA-150 as a tumor suppressor in malignant lymphomaQ39556619
Frequent BCOR aberrations in extranodal NK/T-Cell lymphoma, nasal typeQ40101543
Risk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphoma, nasal type: a multicentre, retrospective analysisQ40188809
PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing l-asparaginase.Q40336693
Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215.Q40506957
A 2.6 Mb interval on chromosome 6q25.2-q25.3 is commonly deleted in human nasal natural killer/T-cell lymphoma.Q40570329
Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study.Q40596015
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphomaQ40717160
Specific c-kit mutations in sinonasal natural killer/T-cell lymphoma in China and JapanQ40879894
CD38 expression predicts poor prognosis and might be a potential therapy target in extranodal NK/T cell lymphoma, nasal typeQ41085075
AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic disseminationQ41140861
Treatment of relapsed extranodal natural killer/T-cell lymphoma with bortezomib plus fludarabineQ41541557
Association between extranodal natural killer/T-cell lymphoma and hepatitis B viral infection: a case-control studyQ41721837
HACE1, a potential tumor suppressor gene on 6q21, is not involved in extranodal natural killer/T-cell lymphoma pathophysiology.Q41746564
PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignanciesQ41826795
Peripheral T-cell and NK-cell lymphomas and their mimics; taking a step forward - report on the lymphoma workshop of the XVIth meeting of the European Association for Haematopathology and the Society for Hematopathology.Q42262315
Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.Q42810702
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectmolecular biologyQ7202
genomicsQ222046
extranodal NK/T-cell lymphoma, nasal typeQ4763254
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)1931
P577publication date2018-06-30
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleThe Genomics and Molecular Biology of Natural Killer/T-Cell Lymphoma: Opportunities for Translation
P478volume19

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cites work (P2860)
Q64085662Molecular pathogenic pathways in extranodal NK/T cell lymphoma
Q64087879Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)
Q90134157Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma
Q61814317Transcriptomic Abnormalities in Epstein Barr Virus Associated T/NK Lymphoproliferative Disorders

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