| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S1535-6108(02)00085-5 |
| P8608 | Fatcat ID | release_bt7hjaarengm3kcx5oalftra5y |
| P698 | PubMed publication ID | 12150825 |
| P50 | author | René Bernards | Q20518809 |
| Daniel Peeper | Q62560307 | ||
| Hendrik Gerard Stunnenberg | Q85416865 | ||
| P2093 | author name string | Benjamin D Rowland | |
| Sirith Douma | |||
| Serguei G Denissov | |||
| P2860 | cites work | Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53 | Q22009955 |
| E2F-6, a member of the E2F family that can behave as a transcriptional repressor | Q24317400 | ||
| Growth suppression by p16ink4 requires functional retinoblastoma protein | Q24317567 | ||
| A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle | Q24319785 | ||
| ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways | Q24321528 | ||
| Interaction between the retinoblastoma protein and the oncoprotein MDM2 | Q24323385 | ||
| Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a | Q24324559 | ||
| The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein | Q24324766 | ||
| p53-independent functions of the p19(ARF) tumor suppressor | Q24600863 | ||
| Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6 | Q24684293 | ||
| The retinoblastoma protein and cell cycle control | Q27860722 | ||
| Surfing the p53 network | Q28032484 | ||
| E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control | Q28141003 | ||
| Atmospheric carbon dioxide concentrations over the past 60 million years | Q28144787 | ||
| Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1 | Q28145116 | ||
| THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS | Q28202269 | ||
| Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest | Q28270478 | ||
| E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription | Q28279690 | ||
| Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes | Q28511710 | ||
| New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2 | Q28585451 | ||
| Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase | Q28612948 | ||
| Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF | Q29619663 | ||
| Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties | Q29620009 | ||
| A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F | Q29620241 | ||
| Nucleolar Arf sequesters Mdm2 and activates p53 | Q29620244 | ||
| Essential role of mouse telomerase in highly proliferative organs | Q29620451 | ||
| A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence | Q30699339 | ||
| Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis | Q33571036 | ||
| Endogenous E2F-1 promotes timely G0 exit of resting mouse embryo fibroblasts | Q33599528 | ||
| A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites | Q33706825 | ||
| Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor | Q33961286 | ||
| Cellular senescence: mitotic clock or culture shock? | Q34019131 | ||
| The Rb/E2F pathway: expanding roles and emerging paradigms | Q34052659 | ||
| The E2F1-3 transcription factors are essential for cellular proliferation. | Q34102966 | ||
| p53: death star | Q34103258 | ||
| Expression of transcription factor E2F1 induces quiescent cells to enter S phase | Q34354875 | ||
| p53 and E2F-1 cooperate to mediate apoptosis | Q35185411 | ||
| Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization | Q35207910 | ||
| p19ARF targets certain E2F species for degradation. | Q35260543 | ||
| E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. | Q35837977 | ||
| Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis | Q35885582 | ||
| Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts | Q36559514 | ||
| The transcription factor E2F-1 is a downstream target of RB action | Q36566621 | ||
| The transcription factor E2F-1 mediates the autoregulation of RB gene expression | Q36643356 | ||
| Distinct roles for E2F proteins in cell growth control and apoptosis | Q36653915 | ||
| Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter | Q36667100 | ||
| Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter | Q36726622 | ||
| E2F is required to prevent inappropriate S-phase entry of mammalian cells | Q39450236 | ||
| Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions | Q40445709 | ||
| Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein | Q40656395 | ||
| Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. | Q40928334 | ||
| E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction | Q41099382 | ||
| Analysis of chromatin structure by in vivo formaldehyde cross-linking. | Q41132202 | ||
| Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition | Q41335802 | ||
| Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. | Q41460849 | ||
| Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts | Q41725165 | ||
| The role of cyclin E in cell proliferation, development and cancer | Q41744187 | ||
| Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint | Q42818873 | ||
| Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice | Q43729271 | ||
| Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis | Q43729274 | ||
| Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression | Q48081415 | ||
| Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16(INK4) and p27(KIP1) to CDKs, loss of E2F-binding activity, and premature senescence of human melanocytes. | Q52537213 | ||
| Tumor surveillance via the ARF-p53 pathway. | Q53430438 | ||
| Escape from premature senescence is not sufficient for oncogenic transformation by Ras. | Q54021692 | ||
| p14ARF links the tumour suppressors RB and p53. | Q55067966 | ||
| p19ARF links the tumour suppressor p53 to Ras | Q57562848 | ||
| Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16 | Q59082348 | ||
| p16INK4A and p19ARF act in overlapping pathways in cellular immortalization | Q60584728 | ||
| Requirements for cell cycle arrest by p16INK4a | Q73074515 | ||
| Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF | Q73707174 | ||
| Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition | Q77310904 | ||
| P433 | issue | 1 | |
| P304 | page(s) | 55-65 | |
| P577 | publication date | 2002-07-01 | |
| P1433 | published in | Cancer Cell | Q280018 |
| P1476 | title | E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest | |
| P478 | volume | 2 |
| Q39763527 | A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence |
| Q34807689 | A kinase shRNA screen links LATS2 and the pRB tumor suppressor |
| Q52058675 | AP-1 dimers regulate transcription of the p14/p19ARF tumor suppressor gene. |
| Q34042864 | ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF. |
| Q40384025 | Activating E2Fs mediate transcriptional regulation of human E2F6 repressor |
| Q39606649 | Activation of nuclear factor-kappa B signalling promotes cellular senescence |
| Q40018751 | Adenovirus E1B55K region is required to enhance cyclin E expression for efficient viral DNA replication. |
| Q24338110 | Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control |
| Q42471717 | Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene |
| Q37802011 | At the stem of youth and health |
| Q34016173 | C/EBPbeta cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence. |
| Q35805158 | Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence |
| Q41839819 | Cell proliferation in the absence of E2F1-3. |
| Q26767454 | Cellular Senescence as the Causal Nexus of Aging |
| Q24629853 | Cellular senescence and tumor suppressor gene p16 |
| Q35062461 | Chemotherapy response and resistance |
| Q33373668 | Context-dependent requirement for dE2F during oncogenic proliferation |
| Q38336456 | Disruption of E2F signaling suppresses the INK4a-induced proliferative defect in M33-deficient mice |
| Q28258356 | Divorcing ARF and p53: an unsettled case |
| Q36143489 | Dmp1 and tumor suppression |
| Q37731957 | E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1. |
| Q33575583 | E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression |
| Q24674252 | E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop |
| Q35119555 | Emerging roles for E2F: Beyond the G1/S transition and DNA replication |
| Q36143502 | Expression of Dmp1 in specific differentiated, nonproliferating cells and its regulation by E2Fs |
| Q40563483 | Hierarchical requirement of SWI/SNF in retinoblastoma tumor suppressor-mediated repression of Plk1. |
| Q45119438 | Hypoxia induces major effects on cell cycle kinetics and protein expression in Drosophila melanogaster embryos. |
| Q24296617 | Impaired DNA damage checkpoint response in MIF-deficient mice |
| Q54659691 | MIF loss impairs Myc-induced lymphomagenesis. |
| Q78826588 | Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformation |
| Q37182019 | Melanomagenesis: overcoming the barrier of melanocyte senescence |
| Q28486255 | Molecular basis for viral selective replication in cancer cells: activation of CDK2 by adenovirus-induced cyclin E |
| Q53380068 | Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss. |
| Q24684949 | NPAT expression is regulated by E2F and is essential for cell cycle progression |
| Q35810716 | Novel ARF/p53-independent senescence pathways in cancer repression. |
| Q40094006 | ORF73-null murine gammaherpesvirus 68 reveals roles for mLANA and p53 in virus replication |
| Q37234252 | Oncogene-induced senescence: an essential role for Runx |
| Q34196515 | Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence |
| Q40550683 | RB reversibly inhibits DNA replication via two temporally distinct mechanisms |
| Q33551923 | Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor |
| Q41914733 | Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53 |
| Q35691573 | Regulating the p53 system through ubiquitination |
| Q39612304 | Regulation of E2Fs and senescence by PML nuclear bodies. |
| Q38028793 | Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers |
| Q40549645 | Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics |
| Q37057033 | Retinoblastoma Tumor Suppressor: Analyses of Dynamic Behavior in Living Cells Reveal Multiple Modes of Regulation |
| Q40674805 | Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. |
| Q45306039 | Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin |
| Q28303509 | Role of the proto-oncogene Pokemon in cellular transformation and ARF repression |
| Q39106989 | SUMOylation of p53 mediates interferon activities |
| Q35181050 | Signal transduction involving the dmp1 transcription factor and its alteration in human cancer |
| Q42668097 | Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress |
| Q37773559 | Small molecule regulators of Rb-E2F pathway as modulators of transcription |
| Q37906461 | Stem cell microRNAs in senescence and immortalization: novel players in cancer therapy |
| Q42050158 | Sustained NF-kappaB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1. |
| Q36344208 | Targeted discovery tools: proteomics and chromatin immunoprecipitation-on-chip |
| Q48384195 | Targeting an E2F site in the mouse genome prevents promoter silencing in quiescent and post-mitotic cells |
| Q28069626 | Targeting the RB-E2F pathway in breast cancer |
| Q35945854 | The E2F family: specific functions and overlapping interests |
| Q34462232 | The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene |
| Q34804764 | The RB and p53 pathways in cancer |
| Q34042999 | The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence |
| Q27027457 | Therapeutic targeting of replicative immortality |
| Q59043918 | Timing will tell |
| Q37660051 | Transcriptional control of the proliferation cluster by the tumor suppressor p53. |
| Q28207959 | Tumor suppression by Ink4a-Arf: progress and puzzles |
| Q37087404 | Versatile functions of p53 protein in multicellular organisms |
| Q34728302 | p14ARF induces apoptosis via an entirely caspase-3-dependent mitochondrial amplification loop. |
| Q35936507 | p16 and ARF: activation of teenage proteins in old age. |
| Q34377287 | p53 Family and Cellular Stress Responses in Cancer |
| Q37602510 | p53 and E2f: partners in life and death |
| Q36547718 | p53-Dependent and -independent functions of the Arf tumor suppressor |
| Q38631683 | p63α protein upregulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion |
| Q40629059 | pRB Contains an E2F1-Specific Binding Domain that Allows E2F1-Induced Apoptosis to Be Regulated Separately from Other E2F Activities |
Search more.