Development of 2,3,5-triaryl-1H-pyrroles as estrogen receptor α selective ligands

scientific article published on 29 August 2011

Development of 2,3,5-triaryl-1H-pyrroles as estrogen receptor α selective ligands is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/CMDC.201100283
P698PubMed publication ID21990277

P50authorGerhard WolberQ42201848
P2093author name stringRonald Gust
Anja Schäfer
Anja Wellner
Martin Strauss
P2860cites workDevelopment and validation of a genetic algorithm for flexible dockingQ28236574
Human estrogen receptor beta-gene structure, chromosomal localization, and expression patternQ28256533
LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filtersQ31143138
Estrogen pyrazoles: defining the pyrazole core structure and the orientation of substituents in the ligand binding pocket of the estrogen receptorQ31988112
Efficient overlay of small organic molecules using 3D pharmacophoresQ34575180
Molecule-pharmacophore superpositioning and pattern matching in computational drug designQ37055387
Synthesis and investigations on the oxidative degradation of C3/C5-alkyl-1,2,4-triarylpyrroles as ligands for the estrogen receptorQ39574240
MCF-7: A human breast cancer cell line with estrogen, androgen, progesterone, and glucocorticoid receptorsQ39976418
Structure-activity relationship study to understand the estrogen receptor-dependent gene activation of aryl- and alkyl-substituted 1H-imidazolesQ40160336
Ring-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum (II) complexes: compounds with a selective effect on the hormone-dependent mammary carcinomaQ42213045
Effect of growth factors on estrogen receptor mediated gene expressionQ42813344
Characterization of new PPARgamma agonists: benzimidazole derivatives-importance of positions 5 and 6, and computational studies on the binding modeQ42824275
Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists.Q43517366
Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alphaQ43732259
Synthesis and biological evaluation of a novel series of furans: ligands selective for estrogen receptor alphaQ43786351
(4R,5S)/(4S,5R)-4,5-Bis(4-hydroxyphenyl)-2-imidazolines: ligands for the estrogen receptor with a novel binding modeQ44078067
Estrogenic diazenes: heterocyclic non-steroidal estrogens of unusual structure with selectivity for estrogen receptor subtypesQ44284933
Invesgations [correction investigations] on the influence of halide substituents on the estrogen receptor interaction of 2, 4, 5-tris(4-hydroxyphenyl)imidazolesQ44634461
1-Benzyl-2-phenylindole- and 1,2-diphenylindole-based antiestrogens. Estimation of agonist and antagonist activities in transfection assaysQ48001030
Investigation of the configurational and conformational influences on the hormonal activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes. 1. Synthesis, estradiol receptor affinity, and estrogenic activQ72317754
Tamoxifen-induced estrogen receptor up-regulation in mammary tumor cells is not related to growth inhibitionQ73050908
Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogensQ74659510
P433issue11
P304page(s)2055-2062
P577publication date2011-08-29
P1433published inChemMedChemQ2962252
P1476titleDevelopment of 2,3,5-triaryl-1H-pyrroles as estrogen receptor α selective ligands
P478volume6

Reverse relations

cites work (P2860)
Q36241225Synthesis and evaluation of 4-(substituted styryl/alkenyl)-3,5-bis(4-hydroxyphenyl)-isoxazoles as ligands for the estrogen receptor
Q36883747Thiophene-core estrogen receptor ligands having superagonist activity.

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