Pharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers

scientific article published on April 2000

Pharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/AAC.44.4.978-984.2000
P932PMC publication ID89801
P698PubMed publication ID10722500

P2093author name stringD F Brophy
Y Lou
B M Sadler
C Gillotin
R E Polk
A Pastor
D S Israel
G E Chittick
W T Symonds
P2860cites workCYP3A4 and the erythromycin breath testQ47722007
Metabolism of amprenavir in liver microsomes: role of CYP3A4 inhibition for drug interactionsQ47900779
Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitorQ48123921
The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin.Q50867766
Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily.Q52553124
In vitro metabolism of a potent HIV-protease inhibitor (141W94) using rat, monkey and human liver S9.Q53994978
Amprenavir.Q54135838
Clarithromycin in vitro activity enhanced by its major metabolite, 14-hydroxyclarithromycinQ68055794
Single- and multiple-dose pharmacokinetics of clarithromycin, a new macrolide antimicrobialQ70502398
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Steady-state pharmacokinetics of delavirdine in HIV-positive patients: effect on erythromycin breath testQ73369035
Molecular and physical mechanisms of first-pass extractionQ77939183
Treatment with amprenavir alone or amprenavir with zidovudine and lamivudine in adults with human immunodeficiency virus infection. AIDS Clinical Trials Group 347 Study Team.Q33539266
Pharmacokinetic interaction between ritonavir and indinavir in healthy volunteersQ33700538
Safety and pharmacokinetics of amprenavir (141W94), a human immunodeficiency virus (HIV) type 1 protease inhibitor, following oral administration of single doses to HIV-infected adults.Q33977160
Noninvasive tests of CYP3A enzymesQ34059919
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitorsQ34065800
Pharmacokinetic interaction between ritonavir and clarithromycinQ34754557
Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.Q35134071
Clarithromycin. A review of its efficacy in the treatment of respiratory tract infections in immunocompetent patientsQ37882764
In vitro antiviral activity of 141W94 (VX-478) in combination with other antiretroviral agentsQ38507949
Effect of clarithromycin on renal excretion of digoxin: interaction with P-glycoproteinQ41018603
HIV-protease inhibitorsQ41751665
Pharmacokinetic interaction between ketoconazole and amprenavir after single doses in healthy men.Q44866694
Pharmacokinetic interactions between two human immunodeficiency virus protease inhibitors, ritonavir and saquinavirQ45756159
Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cellsQ46050952
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectclarithromycinQ118551
pharmacokineticsQ323936
P304page(s)978-984
P577publication date2000-04-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titlePharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers
P478volume44

Reverse relations

cites work (P2860)
Q34127433Amprenavir: a review of its clinical potential in patients with HIV infection
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Q36580598Emerging drugs to replace current leaders in first-line therapy for breast cancer
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