Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking

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Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking is …
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scholarly articleQ13442814

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P356DOI10.1016/J.NEURON.2016.07.005
P932PMC publication ID4991631
P698PubMed publication ID27537483

P50authorChangliang LiuQ56902087
Pascal S KaeserQ87912637
P2093author name stringMan Yan Wong
Richard G Held
Shan Shan H Wang
Aziz Karakhanyan
P2860cites workInteraction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targetingQ24293177
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zonesQ24312023
Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteinsQ24316033
Membrane fusion: grappling with SNARE and SM proteinsQ24633113
Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1Q24671839
Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter releaseQ24676624
Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic VesiclesQ26269831
The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neuronsQ26269841
The presynaptic active zoneQ26269863
Bassoon speeds vesicle reloading at a central excitatory synapse.Q39754011
RIM-binding protein, a central part of the active zone, is essential for neurotransmitter releaseQ39754475
Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapsesQ39755046
Molecular Remodeling of the Presynaptic Active Zone of Drosophila Photoreceptors via Activity-Dependent Feedback.Q41042257
The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegansQ41695648
A post-docking role for active zone protein Rim.Q41977207
Morphological correlates of functionally defined synaptic vesicle populationsQ43558103
Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesisQ43946448
Analyses of the spatiotemporal expression and subcellular localization of liprin-α proteinsQ44721776
The structural organization of the readily releasable pool of synaptic vesiclesQ44814913
Synaptobrevin is essential for fast synaptic-vesicle endocytosisQ45099773
Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2.Q45345777
SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.Q45958930
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.Q45970083
Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesiclesQ46432365
Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle releaseQ47070593
Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmissionQ48144404
RIM-BPs Mediate Tight Coupling of Action Potentials to Ca(2+)-Triggered Neurotransmitter Release.Q52148887
Rapid active zone remodeling during synaptic plasticity.Q52719093
[Synaptic vesicles and pouches at the level of "active zones" of the neuromuscular junction]Q93821507
RIM genes differentially contribute to organizing presynaptic release sitesQ26269874
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zoneQ26269881
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13Q26269920
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interactionQ26269921
ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapsesQ26269927
RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functionsQ26269937
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switchQ26269950
Molecular machines governing exocytosis of synaptic vesiclesQ26849286
Munc13-1 is essential for fusion competence of glutamatergic synaptic vesiclesQ27863297
Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle primingQ28188061
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zoneQ28215837
Short-term synaptic plasticityQ28217342
Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle primingQ28504670
The morphological and molecular nature of synaptic vesicle priming at presynaptic active zonesQ28506683
Differential expression of liprin-α family proteins in the brain suggests functional diversificationQ28506845
The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicingQ28508210
A common molecular basis for membrane docking and functional priming of synaptic vesiclesQ28512083
The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channelsQ28567071
Definition of the readily releasable pool of vesicles at hippocampal synapsesQ29620402
Docking of secretory vesicles is syntaxin dependentQ33268296
Optical mapping of release properties in synapsesQ34085810
Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain.Q34093833
Release probability of hippocampal glutamatergic terminals scales with the size of the active zone.Q36068532
RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle poolQ36469214
Molecular organization of the presynaptic active zoneQ36545836
Determining synaptic parameters using high-frequency activationQ36803564
Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmissionQ36917565
ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains.Q37071725
Hierarchical assembly of presynaptic components in defined C. elegans synapsesQ37566924
Ultrafast endocytosis at mouse hippocampal synapses.Q37642826
Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter releaseQ38166028
Bassoon specifically controls presynaptic P/Q-type Ca(2+) channels via RIM-binding proteinQ39008473
Clathrin-mediated endocytosis is the dominant mechanism of vesicle retrieval at hippocampal synapses.Q39751968
CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.Q39752415
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectRegulating synaptic membrane exocytosis 1Q21983278
ELKS/RAB6-interacting/CAST family member 2Q21984812
ELKS/RAB6-interacting/CAST family member 1Q21987948
Regulating synaptic membrane exocytosis 2Q21990031
P304page(s)777-791
P577publication date2016-08-01
P1433published inNeuronQ3338676
P1476titleFusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking
P478volume91

Reverse relations

cites work (P2860)
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