ELKS active zone proteins as multitasking scaffolds for secretion.

scientific article

ELKS active zone proteins as multitasking scaffolds for secretion. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1098/RSOB.170258
P932PMC publication ID5830537
P698PubMed publication ID29491150

P50authorPascal S KaeserQ87912637
P2093author name stringRichard G Held
P2860cites workThe small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatusQ22254605
ELKS1 and Ca(2+) channel subunit β4 interact and colocalize at cerebellar synapsesQ24298132
An HMM model for coiled-coil domains and a comparison with PSSM-based predictions.Q52040275
RIM-BPs Mediate Tight Coupling of Action Potentials to Ca(2+)-Triggered Neurotransmitter Release.Q52148887
Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor ComplexesQ56992446
Local routes revisited: the space and time dependence of the Ca2+ signal for phasic transmitter release at the rat calyx of HeldQ78872717
Membrane fusionQ81623456
Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriersQ84149697
[Synaptic vesicles and pouches at the level of "active zones" of the neuromuscular junction]Q93821507
Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains.Q41863255
A post-docking role for active zone protein Rim.Q41977207
Loss of the calcium channel β4 subunit impairs parallel fibre volley and Purkinje cell firing in cerebellum of adult ataxic miceQ42414256
Naked dense bodies provoke depression.Q42478978
RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channelsQ42861890
UNC-13 is required for synaptic vesicle fusion in C. elegansQ43240851
Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2.Q45345777
Redundant localization mechanisms of RIM and ELKS in Caenorhabditis elegans.Q46564659
A minimal domain responsible for Munc13 activityQ46755751
Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle releaseQ47070593
Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in DrosophilaQ47072025
Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing.Q47288747
The active zone protein CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampusQ47289037
Transcellular Nanoalignment of Synaptic FunctionQ47990307
Physical and functional interaction of the active zone protein CAST/ERC2 and the β-subunit of the voltage-dependent Ca(2+) channelQ48519130
How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPsQ48564188
Contribution to the problem of structural organization of the presynaptic areaQ49116549
Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.Q49344579
Liprin-α3 controls vesicle docking and exocytosis at the active zone of hippocampal synapsesQ50035046
A 1.5Mb terminal deletion of 12p associated with autism spectrum disorderQ50308424
CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnoverQ24298210
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zonesQ24312023
Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteinsQ24316033
A conformational switch in syntaxin during exocytosis: role of munc18.Q24534308
Membrane fusion: grappling with SNARE and SM proteinsQ24633113
Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1Q24671839
Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter releaseQ24676624
Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter releaseQ24682015
RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapseQ26269826
The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neuronsQ26269841
Neurotransmitter release: the last millisecond in the life of a synaptic vesicleQ26269845
The presynaptic active zoneQ26269863
RIM genes differentially contribute to organizing presynaptic release sitesQ26269874
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zoneQ26269881
Cell biology of Ca2+-triggered exocytosisQ26269905
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13Q26269920
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interactionQ26269921
ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapsesQ26269927
RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functionsQ26269937
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?Q26269969
Molecular machines governing exocytosis of synaptic vesiclesQ26849286
Liprin-α1 and ERC1 control cell edge dynamics by promoting focal adhesion turnoverQ27347496
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolutionQ27765619
Munc13-1 is essential for fusion competence of glutamatergic synaptic vesiclesQ27863297
Drosophila UNC-13 is essential for synaptic transmissionQ28145978
Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle primingQ28188061
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zoneQ28215837
CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CASTQ28238737
CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5betaQ28250713
Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteinsQ28289561
Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle primingQ28504670
The calcium sensor synaptotagmin 7 is required for synaptic facilitationQ28505395
ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains.Q37071725
Formation of Golgi-derived active zone precursor vesicles.Q37117339
Maturation of active zone assembly by Drosophila BruchpilotQ37267704
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.Q37346952
Hierarchical assembly of presynaptic components in defined C. elegans synapsesQ37566924
Ultrafast endocytosis at mouse hippocampal synapses.Q37642826
Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium ChannelsQ37678588
Ca(2+) channels and transmitter release at the active zoneQ38017465
Structure and function of the β subunit of voltage-gated Ca²⁺ channelsQ38043712
CAST: functional scaffold for the integrity of the presynaptic active zoneQ38091781
Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter releaseQ38339903
A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone.Q38429364
Neurosecretion: what can we learn from chromaffin cellsQ38628008
ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.Q38713426
Liprin-α1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration.Q38979205
Bassoon specifically controls presynaptic P/Q-type Ca(2+) channels via RIM-binding proteinQ39008473
The readily releasable pool of synaptic vesiclesQ39095247
Linking cortical microtubule attachment and exocytosisQ39297068
Organization of the presynaptic active zone by ERC2/CAST1-dependent clustering of the tandem PDZ protein syntenin-1.Q39751775
RIM-binding protein, a central part of the active zone, is essential for neurotransmitter releaseQ39754475
Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapsesQ39755046
Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle DockingQ39756941
Rab6 regulates transport and targeting of exocytotic carriersQ40097541
Presynaptic Ca2+ channels compete for channel type-preferring slots in altered neurotransmission arising from Ca2+ channelopathyQ40528552
Synaptotagmins: C2-domain proteins that regulate membrane trafficQ41118335
Mechanisms of short-term plasticity at neuromuscular active zones of DrosophilaQ41788883
Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient miceQ28511824
Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptideQ28564444
The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channelsQ28567071
Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complexQ28569612
Differential expression of two novel Munc13 proteins in rat brainQ28572369
Munc18-1 promotes large dense-core vesicle dockingQ28587706
Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transportQ28592027
Differential control of vesicle priming and short-term plasticity by Munc13 isoformsQ28592163
Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunitQ28592875
A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1Q28595053
Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cellsQ28609753
GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulumQ28609828
Membrane fusionQ29618140
12p13.33 microdeletion including ELKS/ERC1, a new locus associated with childhood apraxia of speechQ30529890
The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesiclesQ30543185
The architecture of active zone material at the frog's neuromuscular junctionQ30981051
Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinomaQ31106255
Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomographyQ33523242
Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and primingQ33702262
Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytesQ33810200
Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinomaQ33862909
Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain.Q34093833
Fusion of cells by flipped SNAREsQ34205790
Timing of neurotransmission at fast synapses in the mammalian brainQ34406384
Synaptic computationQ35918051
The small GTP-binding protein rab6 functions in intra-Golgi transportQ36235031
RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle poolQ36469214
Molecular organization of the presynaptic active zoneQ36545836
Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle primingQ36734003
Nanodomain coupling between Ca²⁺ channels and sensors of exocytosis at fast mammalian synapsesQ36742868
Regulation of membrane fusion in synaptic excitation-secretion coupling: speed and accuracy matterQ36870246
How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter releaseQ36906425
Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zonesQ37044607
Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter releaseQ37071048
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P921main subjectpeptideQ172847
nerve tissue proteinQ6996861
P577publication date2018-02-01
P1433published inOpen BiologyQ7095958
P1476titleELKS active zone proteins as multitasking scaffolds for secretion
P478volume8

Reverse relations

cites work (P2860)
Q58553974Coupling the Structural and Functional Assembly of Synaptic Release Sites
Q90246164Presynaptic calcium channels: specialized control of synaptic neurotransmitter release
Q89999397Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells
Q98188948Synapse development and maturation at the drosophila neuromuscular junction
Q103756649Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins

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