The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons

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The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.0999-14.2014
P8608Fatcat IDrelease_fezwp3zsujbernr3x5hnyagqqq
P3181OpenCitations bibliographic resource ID1100498
P932PMC publication ID4160768
P698PubMed publication ID25209271

P50authorThomas C. SüdhofQ97270
Changliang LiuQ56902087
Pascal S KaeserQ87912637
P2093author name stringRichard G Held
Hajnalka Nyitrai
Lydia S Bickford
P2860cites workActivation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunitQ24297861
ELKS1 and Ca(2+) channel subunit β4 interact and colocalize at cerebellar synapsesQ24298132
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zonesQ24312023
Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1Q24671839
The presynaptic active zoneQ26269863
RIM genes differentially contribute to organizing presynaptic release sitesQ26269874
A dual-Ca2+-sensor model for neurotransmitter release in a central synapseQ26269875
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zoneQ26269881
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosisQ26269909
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13Q26269920
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interactionQ26269921
ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapsesQ26269927
RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functionsQ26269937
Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+Q26269939
Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter releaseQ26269947
Munc13-1 is essential for fusion competence of glutamatergic synaptic vesiclesQ27863297
Synaptotagmin I functions as a calcium regulator of release probabilityQ28204147
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zoneQ28215837
CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CASTQ28238737
International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channelsQ28289138
Differential expression of active zone proteins in neuromuscular junctions suggests functional diversificationQ28571292
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein familyQ28589218
Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transportQ28592027
Differential control of vesicle priming and short-term plasticity by Munc13 isoformsQ28592163
Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cellsQ29618298
Synaptic assembly of the brain in the absence of neurotransmitter secretionQ29618899
Definition of the readily releasable pool of vesicles at hippocampal synapsesQ29620402
Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refillingQ30497701
The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesiclesQ30543185
The architecture of active zone material at the frog's neuromuscular junctionQ30981051
Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinomaQ33862909
Homo- and heterodimerization of synapsinsQ33864060
Active zone protein Bassoon co-localizes with presynaptic calcium channel, modifies channel function, and recovers from aging related loss by exerciseQ34305261
Short-term synaptic plasticity is altered in mice lacking synapsin I.Q34321716
Beta subunits of voltage-gated calcium channelsQ35682310
Activity-dependent regulation of inhibition via GAD67Q36073372
RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle poolQ36469214
Maturation of active zone assembly by Drosophila BruchpilotQ37267704
UNC-13 and UNC-10/rim localize synaptic vesicles to specific membrane domains.Q37417587
Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic miceQ37577945
Molecular organization and plasticity of the cytomatrix at the active zoneQ37949766
New insights into molecular players involved in neurotransmitter release.Q37982009
Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter releaseQ38166028
Pushing synaptic vesicles over the RIM.Q38437297
Bassoon specifically controls presynaptic P/Q-type Ca(2+) channels via RIM-binding proteinQ39008473
RIM-binding protein, a central part of the active zone, is essential for neurotransmitter releaseQ39754475
Rab6 regulates transport and targeting of exocytotic carriersQ40097541
Presynaptic Ca2+ channels compete for channel type-preferring slots in altered neurotransmission arising from Ca2+ channelopathyQ40528552
RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels.Q41770497
Mechanisms of short-term plasticity at neuromuscular active zones of DrosophilaQ41788883
A post-docking role for active zone protein Rim.Q41977207
Naked dense bodies provoke depression.Q42478978
RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channelsQ42861890
Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic densityQ43241214
Development of vesicle pools during maturation of hippocampal synapses.Q43875561
Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions.Q45935043
SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.Q45958930
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.Q45970083
Redundant localization mechanisms of RIM and ELKS in Caenorhabditis elegans.Q46564659
Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle releaseQ47070593
Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in DrosophilaQ47072025
Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing.Q47288747
Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulationQ48363143
Physical and functional interaction of the active zone protein CAST/ERC2 and the β-subunit of the voltage-dependent Ca(2+) channelQ48519130
On the relationship between calcium concentration and the amplitude of the end-plate potentialQ72241711
Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriersQ84149697
[Synaptic vesicles and pouches at the level of "active zones" of the neuromuscular junction]Q93821507
P4510describes a project that usesImageJQ1659584
P433issue37
P407language of work or nameEnglishQ1860
P921main subjectprotein familyQ417841
ELKS/RAB6-interacting/CAST family member 1Q21987948
P304page(s)12289-303
P577publication date2014-09-10
P1433published inJournal of NeuroscienceQ1709864
P1476titleThe active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons
P478volume34

Reverse relations

cites work (P2860)
Q89568534CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse
Q58553974Coupling the Structural and Functional Assembly of Synaptic Release Sites
Q60238537Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance
Q49344579Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.
Q53840590ELKS active zone proteins as multitasking scaffolds for secretion.
Q37071725ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains.
Q38713426ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.
Q47852140Efficient stimulus-secretion coupling at ribbon synapses requires RIM-binding protein tethering of L-type Ca2+ channels
Q39756941Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking
Q64109077Imaging and Analysis of Presynaptic Calcium Influx in Cultured Neurons Using synGCaMP6f
Q91595167Impaired experience-dependent maternal care in presynaptic active zone protein CAST-deficient dams
Q26766019Molecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active Zone
Q38373274Plasma membrane-associated platforms: dynamic scaffolds that organize membrane-associated events.
Q90246164Presynaptic calcium channels: specialized control of synaptic neurotransmitter release
Q89999397Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells
Q33810200Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes
Q89569478Spatiotemporal dynamics of multi-vesicular release is determined by heterogeneity of release sites within central synapses
Q90053610Targeting the cholinergic system in Parkinson's disease
Q91063338The control of release probability at nerve terminals
Q38365576The presynaptic active zone: A dynamic scaffold that regulates synaptic efficacy
Q47990307Transcellular Nanoalignment of Synaptic Function
Q39420011Vertebrate Presynaptic Active Zone Assembly: a Role Accomplished by Diverse Molecular and Cellular Mechanisms
Q90685525Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear

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