Chloroquine inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis

scientific article

Chloroquine inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1080/07357900802427927
P698PubMed publication ID19194831

P2093author name stringYuquan Wei
Xia Zhao
Shengyong Yang
Ying-Lan Zhao
Zhengguang Li
Yongqiu Mao
Yuzhu Zheng
Peidu Jiang
Xiaoqiang Deng
P2860cites workA phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cellsQ22253428
Signalling pathways of the TNF superfamily: a double-edged swordQ29616428
Cancer statistics, 2004Q29620739
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesisQ30480882
Cytoplasmic vacuolation, adaptation and cell death: a view on new perspectives and featuresQ33779363
Clinical studies of apoptosis and proliferation in breast cancerQ33872956
Induction of apoptosis by cancer chemotherapy.Q33876771
Effects of chloroquine on viral infections: an old drug against today's diseases?Q33973620
Resistance to tumor necrosis factor-induced cell death mediated by PMCA4 deficiencyQ34012937
BH3-Only proteins-essential initiators of apoptotic cell deathQ34117362
DNA damage-induced apoptosisQ34312499
Resveratrol and cancer: chemoprevention, apoptosis, and chemo-immunosensitizing activitiesQ35101017
The role of radiation-induced apoptosis as a determinant of tumor responses to radiation therapyQ35591574
Apoptosis and chemotherapy for bladder cancerQ36042077
Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolinQ40244807
Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitorQ40290597
Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cellsQ40329437
Chloroquine-mediated radiosensitization is due to the destabilization of the lysosomal membrane and subsequent induction of cell death by necrosis.Q40378981
Inhibition of mitogen-activated protein kinase signaling by chloroquineQ40733870
Control of mammary tumor cell growth in vitro by novel cell differentiation and apoptosis agentsQ41916902
Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independentQ41918709
Chloroquine interferes with lipopolysaccharide-induced TNF-alpha gene expression by a nonlysosomotropic mechanismQ41921412
Chloroquine inhibits production of TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modesQ41946037
Selective growth inhibition of ductal pancreatic adenocarcinoma cells by the lysosomotropic agent chloroquineQ41946781
Antitumor activity of gefitinib in malignant rhabdoid tumor cells in vitro and in vivoQ42800684
Induction of apoptosis by norcantharidin in human colorectal carcinoma cell lines: involvement of the CD95 receptor/ligandQ43949213
Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells.Q55470416
P433issue3
P921main subjectcell growthQ189159
chloroquineQ422438
colon cancerQ18555025
P304page(s)286-292
P577publication date2009-03-01
P1433published inCancer InvestigationQ325953
P1476titleChloroquine inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis
P478volume27

Reverse relations

cites work (P2860)
Q42773826A general synthetic procedure for 2-chloromethyl-4(3H)-quinazolinone derivatives and their utilization in the preparation of novel anticancer agents with 4-anilinoquinazoline scaffolds.
Q39380382A novel anticancer agent, SKLB70359, inhibits human hepatic carcinoma cells proliferation via G0/G1 cell cycle arrest and apoptosis induction
Q98613644Anti-malarial Drugs Reduce Vascular Smooth Muscle Cell Proliferation via Activation of AMPK and Inhibition of Smad3 Signaling
Q42768345Caffeic acid induces apoptosis in human cervical cancer cells through the mitochondrial pathway
Q38787312Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells
Q50053658Chloroquine exerts antitumor effects on NB4 acute promyelocytic leukemia cells and functions synergistically with arsenic trioxide
Q36425775Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo
Q41912057Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension.
Q33632727Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells
Q39357846Chloroquine-mediated lysosomal dysfunction enhances the anticancer effect of nutrient deprivation
Q54218397Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review.
Q39562925Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis
Q39347335Design, synthesis and antiproliferative activity of novel 2-substituted-4-amino-6-halogenquinolines
Q31170767Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma
Q41416283Glucose Restriction Combined with Autophagy Inhibition and Chemotherapy in HCT 116 Spheroids Decreases Cell Clonogenicity and Viability Regulated by Tumor Suppressor Genes.
Q37827403Hydroxychloroquine: from malaria to autoimmunity
Q41933492Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics
Q36157982Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression.
Q28306357Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism
Q41912065In vitro and in vivo antitumor effects of chloroquine on oral squamous cell carcinoma
Q33731804New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets
Q39424775Novel pyrazolo[3,4-d]pyrimidine derivatives as potential antitumor agents: exploratory synthesis, preliminary structure-activity relationships, and in vitro biological evaluation
Q39655104Novel thienopyridine derivatives as specific anti-hepatocellular carcinoma (HCC) agents: Synthesis, preliminary structure–activity relationships, and in vitro biological evaluation
Q39444979Nutritional stress and arginine auxotrophy confer high sensitivity to chloroquine toxicity in mesothelioma cells
Q47162451Repurposing Drugs in Oncology (ReDO)-chloroquine and hydroxychloroquine as anti-cancer agents.
Q39432359Suppression of autophagy by chloroquine sensitizes 5-fluorouracil-mediated cell death in gallbladder carcinoma cells
Q39016400Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells
Q60924217Toward fully exploiting the therapeutic potential of marketed pharmaceuticals: the use of octreotide and chloroquine in oncology
Q36403652Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

Search more.