human | Q5 |
P496 | ORCID iD | 0000-0002-3378-3967 |
P69 | educated at | University of Zurich | Q206702 |
P108 | employer | University of Zurich | Q206702 |
P734 | family name | Honegger | Q1626822 |
Honegger | Q1626822 | ||
Honegger | Q1626822 | ||
P735 | given name | ??? | Q18091447 |
??? | Q18091447 | ||
P106 | occupation | researcher | Q1650915 |
P21 | sex or gender | female | Q6581072 |
Q41148860 | A combined NMR and computational approach to investigate peptide binding to a designed Armadillo repeat protein |
Q33224274 | A mutation designed to alter crystal packing permits structural analysis of a tight-binding fluorescein-scFv complex |
Q54572063 | A natural antibody missing a cysteine in VH: consequences for thermodynamic stability and folding. |
Q41091475 | A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction |
Q24310428 | A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1 |
Q47547452 | Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control. |
Q36889497 | Affinity and folding properties both influence the selection of antibodies with the selectively infective phage (SIP) methodology. |
Q42069677 | Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase |
Q28626012 | All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor |
Q56896879 | Antibody scFv fragments without disulfide bonds made by molecular evolution |
Q41092861 | Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites |
Q31122335 | Biophysical properties of human antibody variable domains |
Q39204394 | CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells |
Q42146689 | Chemical modification of peptides by hydrazine |
Q41821194 | Comparison of buffers and detection systems for high-pressure liquid chromatography of peptide mixtures |
Q27728111 | Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition |
Q57840015 | Correlation between in Vitro Stability and in Vivo Performance of Anti-GCN4 Intrabodies as Cytoplasmic Inhibitors |
Q34292126 | Critical features for biosynthesis, stability, and functionality of a G protein-coupled receptor uncovered by all-versus-all mutations |
Q27639109 | Crystal structure of the anti-His tag antibody 3D5 single-chain fragment complexed to its antigen |
Q40819546 | Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors |
Q27704252 | DARPin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography |
Q34036904 | DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency |
Q27676519 | Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters |
Q30845963 | Direct in vivo screening of intrabody libraries constructed on a highly stable single-chain framework |
Q52525981 | Disrupting the hydrophobic patches at the antibody variable/constant domain interface: improved in vivo folding and physical characterization of an engineered scFv fragment. |
Q46380702 | Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability |
Q57174193 | Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells |
Q38926881 | Efficient cell-specific uptake of binding proteins into the cytoplasm through engineered modular transport systems |
Q112645163 | Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action |
Q37028978 | Engineering antibodies for stability and efficient folding. |
Q42025518 | Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells |
Q41730272 | Expression of a human insulin-like growth factor II cDNA in NIH-3T3 cells |
Q57840110 | Folding Nuclei of the scFv Fragment of an Antibody† |
Q41739529 | Generation of recombinant cytoplasmic domain of epidermal growth factor receptor with intrinsic protein tyrosine kinase activity |
Q56896411 | High thermal stability is essential for tumor targeting of antibody fragments: engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment |
Q27620017 | Insight into odorant perception: the crystal structure and binding characteristics of antibody fragments directed against the musk odorant traseolide |
Q58450636 | Insulin-like growth factors I and II in fetal and adult bovine serum. Purification, primary structures, and immunological cross-reactivities |
Q27315979 | Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS-p110 crosstalk |
Q41092869 | Kinetic parameters of the protein tyrosine kinase activity of EGF-receptor mutants with individually altered autophosphorylation sites |
Q41846083 | Metabolic effects induced by epidermal growth factor (EGF) in cells expressing EGF receptor mutants |
Q42806503 | Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing |
Q30195382 | Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor |
Q38906090 | Receptor-targeted lentiviral vectors are exceptionally sensitive toward the biophysical properties of the displayed single-chain Fv. |
Q32000846 | Reproducing the natural evolution of protein structural features with the selectively infective phage (SIP) technology. The kink in the first strand of antibody kappa domains. |
Q41330278 | Rigidly connected multispecific artificial binders with adjustable geometries. |
Q30810332 | Selection for improved protein stability by phage display. |
Q27632404 | Selection, characterization and x-ray structure of anti-ampicillin single-chain Fv fragments from phage-displayed murine antibody libraries |
Q42832582 | Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells |
Q58450633 | Signal Transduction by Epidermal Growth Factor Receptor |
Q56897080 | Specific detection of his-tagged proteins with recombinant anti-His tag scFv-phosphatase or scFv-phage fusions |
Q35863490 | Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering |
Q40005721 | Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework |
Q27686917 | Structural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2 |
Q30885937 | Structure-based improvement of the biophysical properties of immunoglobulin VH domains with a generalizable approach |
Q45881214 | T-cell receptor gene transfer exclusively to human CD8(+) cells enhances tumor cell killing |
Q42173081 | The behaviour of peptides on reverse-phase supports during high-pressure liquid chromatography |
Q39828671 | The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies. |
Q27632417 | The importance of framework residues H6, H7 and H10 in antibody heavy chains: experimental evidence for a new structural subclassification of antibody V(H) domains |
Q43633084 | The influence of the buried glutamine or glutamate residue in position 6 on the structure of immunoglobulin variable domains |
Q46167685 | The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains |
Q57840080 | The nature of antibody heavy chain residue H6 strongly influences the stability of a VH domain lacking the disulfide bridge |
Q31142518 | Turnover-based in vitro selection and evolution of biocatalysts from a fully synthetic antibody library. |
Q57840011 | Yet Another Numbering Scheme for Immunoglobulin Variable Domains: An Automatic Modeling and Analysis Tool |
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