Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters

scientific article

Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2013PNAS..110E.869D
P356DOI10.1073/PNAS.1213653110
P932PMC publication ID3593905
P698PubMed publication ID23431166
P5875ResearchGate publication ID235691713

P50authorAndreas PlückthunQ23057697
Annemarie HoneggerQ40005792
P2093author name stringVictor Krasnykh
Markus G Grütter
Peer R E Mittl
Natalya Belousova
Galina Mikheeva
Christian Hess
Birgit Dreier
Gabriela Nagy-Davidescu
P2860cites workHCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackievirusesQ24312224
Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosisQ24317713
In vitro selection and evolution of functional proteins by using ribosome displayQ24643887
Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CARQ27620424
A designed ankyrin repeat protein evolved to picomolar affinity to Her2Q27644627
High-affinity binders selected from designed ankyrin repeat protein librariesQ28257550
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5Q28303765
Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachmentQ29615852
Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins.Q30979207
Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries.Q31967754
The 'adenobody' approach to viral targeting: specific and enhanced adenoviral gene deliveryQ32162676
Ribosome display: selecting and evolving proteins in vitro that specifically bind to a targetQ33275939
Folding and unfolding mechanism of highly stable full-consensus ankyrin repeat proteins.Q33312735
Efficient selection of DARPins with sub-nanomolar affinities using SRP phage displayQ33360541
Her2-specific multivalent adapters confer designed tropism to adenovirus for gene targetingQ33740415
Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cellsQ33808695
Mutations in the DG loop of adenovirus type 5 fiber knob protein abolish high-affinity binding to its cellular receptor CAR.Q33823521
DARPins and other repeat protein scaffolds: advances in engineering and applicationsQ33946122
Genetic targeting of adenoviral vectorsQ33996499
DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalencyQ34036904
Ribosome display: a perspectiveQ34077250
Rapid selection of high-affinity binders using ribosome displayQ34077293
Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular sizeQ34096303
Development of a targeted gene vector platform based on simian adenovirus serotype 24.Q34120794
Designed ankyrin repeat proteins (DARPins) from research to therapyQ34122106
Targeting of adenovirus via genetic modification of the viral capsid combined with a protein bridgeQ34226547
Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1.Q34281830
Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectorsQ34282191
Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complementQ34597583
Separating fact from fiction: assessing the potential of modified adenovirus vectors for use in human gene therapyQ34729600
Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.Q34781681
How does your virus grow? Understanding and interfering with virus assemblyQ35587585
The coxsackie-adenovirus receptor--a new receptor in the immunoglobulin family involved in cell adhesion.Q35607448
A transductionally retargeted adenoviral vector for virotherapy of Her2/neu-expressing prostate cancerQ35678429
Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recyclingQ35842099
Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodiesQ35870207
Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism.Q35870225
Gene therapy: twenty-first century medicineQ36161193
The influence of adenovirus fiber structure and function on vector development for gene therapyQ36182171
Genetic targeting strategies for adenovirusQ36273182
Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivoQ36535456
Engineering targeted viral vectors for gene therapyQ36868494
Gene therapy clinical trials worldwide to 2007--an update.Q36920192
Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transferQ37291653
Insights into adenovirus host cell interactions from structural studiesQ37329603
Adenoviruses: update on structure and functionQ37352487
Advances and future challenges in adenoviral vector pharmacology and targetingQ37859842
Tropism-modification strategies for targeted gene delivery using adenoviral vectorsQ38614156
Adenovirus type 37 uses sialic acid as a cellular receptorQ39588484
Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber proteinQ39589919
Functional and selective targeting of adenovirus to high-affinity Fcgamma receptor I-positive cells by using a bispecific hybrid adapterQ39601286
A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activityQ39632060
Targeting adenoviral vectors by using the extracellular domain of the coxsackie-adenovirus receptor: improved potency via trimerizationQ39682554
Selective targeting of adenovirus to alphavbeta3 integrins, VEGFR2 and Tie2 endothelial receptors by angio-adenobodiesQ39730829
Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli.Q39875310
Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapyQ39876759
Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins.Q39882081
Genetically targeted adenovirus vector directed to CD40-expressing cellsQ40012083
Modification of adenovirus capsid with a designed protein ligand yields a gene vector targeted to a major molecular marker of cancerQ40055106
Enhanced gene transfer to mouse dendritic cells using adenoviral vectors coated with a novel adapter moleculeQ40560830
Use of recombinant adenovirus for metabolic engineering of mammalian cells.Q40571045
Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridaeQ40917425
Targeting adenoviruses with factor x-single-chain antibody fusion proteinsQ42533800
Enhancement of adenovirus-mediated gene delivery by use of an oligopeptide with dual binding specificityQ42808670
A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivoQ42833222
Facile double-functionalization of designed ankyrin repeat proteins using click and thiol chemistriesQ44324837
Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunityQ45857523
CD46 is a cellular receptor for group B adenovirusesQ45869560
Adenovirus serotype 5 hexon mediates liver gene transferQ45875068
Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain.Q45882880
Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, alphav integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicityQ50094012
Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors.Q50895162
Kinetic stability and crystal structure of the viral capsid protein SHP.Q53881791
Designed ankyrin repeat proteins: a novel tool for testing epidermal growth factor receptor 2 expression in breast cancer.Q54672530
Residue-Resolved Stability of Full-Consensus Ankyrin Repeat Proteins Probed by NMRQ57839920
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
P304page(s)E869-77
P577publication date2013-03-05
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleDevelopment of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters
P478volume110

Reverse relations

cites work (P2860)
Q512382559th annual European Antibody Congress, November 11-13, 2013, Geneva, Switzerland.
Q57839812A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors
Q24298137A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway
Q47547452Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.
Q42220090An application of capsid-specific artificial ankyrin repeat protein produced in E. coli for immunochromatographic assay as a surrogate for antibody
Q36333938Beyond Antibodies as Binding Partners: The Role of Antibody Mimetics in Bioanalysis
Q57059568Bispecific applications of non-immunoglobulin scaffold binders
Q36827348Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors
Q93015560DARPins: Promising Scaffolds for Theranostics
Q55467684Designer Oncolytic Adenovirus: Coming of Age.
Q35017003Mutation in fiber of adenovirus serotype 5 gene therapy vector decreases liver tropism
Q24567699New viruses for cancer therapy: meeting clinical needs
Q26776553Oncolytic Adenovirus: Strategies and Insights for Vector Design and Immuno-Oncolytic Applications
Q33584756Peptide-based technologies to alter adenoviral vector tropism: ways and means for systemic treatment of cancer
Q38899428Recent progress in protein-protein interaction study for EGFR-targeted therapeutics
Q41330278Rigidly connected multispecific artificial binders with adjustable geometries.
Q90290727TRIM21-From Intracellular Immunity to Therapy
Q43791957Techniques and applications: Change of address for adenoviruses
Q93015565The Role of Interleukin-37 in the Pathogenesis of Allergic Diseases
Q91768182Unravelling Receptor and RGD Motif Dependence of Retargeted Adenoviral Vectors using Advanced Tumor Model Systems

Search more.