Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation

scientific article published on March 1994

Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID236626
P698PubMed publication ID8107228

P2093author name stringY Q Wu
B Turk
M C Mumby
K Rundell
A Porrás
K Enderle
S Mungre
P2860cites workIdentification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirusQ24337360
Association of protein phosphatase 2A with polyoma virus medium tumor antigenQ24558730
Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa proteinQ24603540
Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigenQ24603984
Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunitsQ28212228
Simian virus 40 small tumor antigen and an amino-terminal domain of large tumor antigen share a common transforming functionQ33812137
Simian virus 40 small t antigen trans activates the adenovirus E2A promoter by using mechanisms distinct from those used by adenovirus E1AQ33933744
Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.Q34181194
Effect of zinc ions on the biochemical behavior of simian virus 40 small-t antigen expressed in bacteriaQ34233425
Monoclonal antibodies specific for simian virus 40 tumor antigensQ34249232
Simian virus 40 small-t antigen binds two zinc ions.Q34356047
Common and unique features of T antigens encoded by the polyomavirus groupQ35228997
Association of cellular 56,000- and 32,000-molecular-weight protein with BK virus and polyoma virus t-antigensQ35236642
Nucleotide sequence analysis of viable deletion mutants lacking segments of the simian virus 40 genome coding for small t antigenQ36498585
Cellular proteins associated with simian virus 40 early gene products in newly infected cellsQ36503362
Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulationQ36681859
Association of simian virus 40 small-t antigen with the 61-kilodalton component of a cellular protein complexQ36793568
Mutational analysis of simian virus 40 small-t antigenQ36807764
Simian virus 40 small-t does not transactivate RNA polymerase II promoters in virus infectionsQ36828044
Interaction of simian virus 40 small-T antigen produced in bacteria with 56K and 32K proteins of animal cellsQ36851463
Homologous cellular proteins associated with simian virus 40 small T antigen and polyomavirus medium T antigenQ36874390
Failure of simian virus 40 small t antigen to disorganize actin cables in nonpermissive cell linesQ36875651
The t-unique coding domain is important to the transformation maintenance function of the simian virus 40 small t antigenQ36912213
New region of the simian virus 40 genome required for efficient viral transformationQ37587068
Amino acid sequence homology between polyoma and SV40 tumour antigens deduced from nucleotide sequencesQ40167483
The roles of the simian virus 40 tumor antigens in transformation of chinese hamster lung cellsQ40251500
The 55 kDa regulatory subunit of protein phosphatase 2A plays a role in the activation of the HPV16 long control region in human cells with a deletion in the short arm of chromosome 11.Q41086433
A new member of the polyomavirus family: the hamster papovavirus. Complete nucleotide sequence and transformation properties.Q41393337
Control of protein phosphatase 2A by simian virus 40 small-t antigenQ41814391
trans-activation of RNA polymerase II and III promoters by SV40 small t antigenQ43855223
Isolation and partial characterization of an Mr 60,000 subunit of a type 2A phosphatase from rabbit reticulocytesQ69340961
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectSV40Q734305
P304page(s)1675-1681
P577publication date1994-03-01
P1433published inJournal of VirologyQ1251128
P1476titleMutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation
P478volume68

Reverse relations

cites work (P2860)
Q35870456A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays.
Q35897814A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice.
Q35839944Amino-terminal regions of polyomavirus middle T antigen are required for interactions with protein phosphatase 2A.
Q39582923Cell cycle progression in monkey cells expressing simian virus 40 small t antigen from adenovirus vectors.
Q38632111Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function
Q38290890Cooperation of simian virus 40 large and small T antigens in metabolic stabilization of tumor suppressor p53 during cellular transformation
Q36727304Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts
Q40000679Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: inhibition by small t antigen
Q33788939Effects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infection
Q34117528Enumeration of the simian virus 40 early region elements necessary for human cell transformation
Q47143783Human Polyomaviruses: The Battle of Large and Small Tumor Antigens
Q24316472Identification of PP2A complexes and pathways involved in cell transformation
Q35839940Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A.
Q36255511Immortalized cells as experimental models to study cancer.
Q24648223Induction of cyclin D1 by simian virus 40 small tumor antigen
Q39604079Induction of p53-independent apoptosis by simian virus 40 small t antigen
Q33582162JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity
Q22253161Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression
Q39604427Overexpression of simian virus 40 small-T antigen blocks centrosome function and mitotic progression in human fibroblasts
Q39369307PP2A inactivation is a crucial step in triggering apoptin-induced tumor-selective cell killing
Q36954633PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen
Q33288788PP2A-mediated dephosphorylation of p107 plays a critical role in chondrocyte cell cycle arrest by FGF
Q33985022PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length
Q42065661Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens
Q27026038Regulation of PP2A by Sphingolipid Metabolism and Signaling
Q36328297Role of SV40 ST antigen in the persistent infection of mesothelial cells
Q36737600SV40 reporter viruses.
Q40021232Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells
Q39576996Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A.
Q36524828Simian virus 40 T antigens and J domains: analysis of Hsp40 cochaperone functions in Escherichia coli
Q30435809Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor
Q39733486Simian virus 40 small tumor antigen induces deregulation of the actin cytoskeleton and tight junctions in kidney epithelial cells
Q34714730Small tumor antigen of polyomaviruses: role in viral life cycle and cell transformation
Q27646534Structural Basis of PP2A Inhibition by Small t Antigen
Q37511197T antigen transgenic mouse models
Q34662543T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis
Q39549966The simian virus 40 small-t and large-T antigens jointly regulate cell cycle reentry in human fibroblasts
Q33925306Transformation of human and murine fibroblasts without viral oncoproteins
Q36016730p27kip1 protein levels reflect a nexus of oncogenic signaling during cell transformation
Q39589009pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression

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