Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction

scientific article published on December 2003

Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/GAD.1153603
P932PMC publication ID305254
P698PubMed publication ID14701872
P5875ResearchGate publication ID8937219

P50authorEdward M. De RobertisQ5344257
P2093author name stringAtsushi Ikeda
Edward Eivers
Edgar M Pera
P2860cites workFGF signaling and the anterior neural induction in Xenopus.Q52171585
Evidence for antagonism of BMP-4 signals by MAP kinase during Xenopus axis determination and neural specification.Q52551781
Gastrulation and larval pattern in Xenopus after blastocoelic injection of a Xenopus-derived inducing factor: Experiments testing models for the normal organization of mesodermQ57340251
A role for HGF/SF in neural induction and its expression in Hensen's node during gastrulationQ59971496
An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryoQ73761941
Bmp4 and Fgf10 play opposing roles during lung bud morphogenesisQ73815422
Neural inductionQ73977540
Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural patternQ24319689
Controlling TGF-beta signalingQ28139621
Oncogenic kinase signallingQ28189493
Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1Q28251731
Neural inductionQ33804334
Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway.Q33890835
The establishment of Spemann's organizer and patterning of the vertebrate embryoQ34185421
The BMP antagonist noggin regulates cranial suture fusionQ34189687
Neural induction: toward a unifying mechanismQ34425366
The role of growth factors in tooth developmentQ34645503
Induction and initial patterning of the nervous system - the chick embryo enters the sceneQ34723587
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic RasQ35193411
FGF-4 and BMP-2 have opposite effects on limb growth.Q40869516
Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2.Q41123230
The IGF pathway regulates head formation by inhibiting Wnt signaling in XenopusQ43955167
Nuclear exclusion of Smad2 is a mechanism leading to loss of competenceQ44030633
Neural and head induction by insulin-like growth factor signalsQ46842475
Initiation of neural induction by FGF signalling before gastrulation.Q47845943
FGF-8 is associated with anteroposterior patterning and limb regeneration in XenopusQ48040919
Comparative effects of insulin on the activation of the Raf/Mos-dependent MAP kinase cascade in vitellogenic versus postvitellogenic Xenopus oocytesQ48954204
The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm.Q52110657
Beta-catenin, MAPK and Smad signaling during early Xenopus development.Q52125459
FGF-8 stimulates neuronal differentiation through FGFR-4a and interferes with mesoderm induction in Xenopus embryos.Q52143559
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
neural inductionQ109315552
P304page(s)3023-3028
P577publication date2003-12-01
P1433published inGenes & DevelopmentQ1524533
P1476titleIntegration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction
P478volume17

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cites work (P2860)
Q28117797A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal
Q37338950A negative feedback control of transforming growth factor-beta signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204.
Q37201465A role for Syndecan-4 in neural induction involving ERK- and PKC-dependent pathways
Q35062218Active signals, gradient formation and regional specificity in neural induction
Q30871375All-trans retinoic acid promotes neural lineage entry by pluripotent embryonic stem cells via multiple pathways
Q35652345An ancient chordin-like gene in organizer formation of Hydra
Q41928071Antagonism between Notch and bone morphogenetic protein receptor signaling regulates neurogenesis in the cerebellar rhombic lip.
Q36815556Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region
Q36726890Assessment of stromal-derived inducing activity in the generation of dopaminergic neurons from human embryonic stem cells
Q43540868Attenuation of Smad2 activity shows resistance to TGF-β signalling in mammary adenocarcinoma (MCF-7) cells
Q55346231BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity.
Q42214355BMP antagonists and FGF signaling contribute to different domains of the neural plate in Xenopus
Q28507269BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation
Q37394829BMP inhibition initiates neural induction via FGF signaling and Zic genes.
Q36659526BMP signaling in the cartilage growth plate.
Q33612220BMP-2/6 heterodimer is more effective than BMP-2 or BMP-6 homodimers as inductor of differentiation of human embryonic stem cells
Q37317784BMPs oppose Math1 in cerebellar development and in medulloblastoma.
Q34405302Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells
Q36191535Basic fibroblast growth factor support of human embryonic stem cell self-renewal
Q58745068Bighead is a Wnt antagonist secreted by the Spemann organizer that promotes Lrp6 endocytosis
Q36524114Biological characterization of metanephric mesenchymal stem cells from the Beijing duck
Q37024248Biological spacetime and the temporal integration of functional modules: a case study of dento-gnathic developmental timing.
Q47074228Bmp5 Regulates Neural Crest Cell Survival and Proliferation via Two Different Signaling Pathways.
Q36337906Bone morphogenetic protein signalling and vertebrate nervous system development
Q39288437Calcineurin signaling regulates neural induction through antagonizing the BMP pathway
Q60921078Calcium mimics the chemotactic effect of conditioned media and is an effective inducer of bone regeneration
Q36906835Calfacilitin is a calcium channel modulator essential for initiation of neural plate development
Q34698134Cell aggregation-induced FGF8 elevation is essential for P19 cell neural differentiation
Q37924871Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle
Q33424471Characterisation of the fibroblast growth factor dependent transcriptome in early development
Q81396838Chordin, FGF signaling, and mesodermal factors cooperate in zebrafish neural induction
Q28312207Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains
Q38332721Conditional BMP inhibition in Xenopus reveals stage-specific roles for BMPs in neural and neural crest induction
Q52593116Contextual determinants of TGFβ action in development, immunity and cancer.
Q24337748Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1
Q35606917Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.
Q38026860Cross-talk between FGF and other cytokine signalling pathways during endochondral bone development
Q37526818Crosstalk between Wnt and bone morphogenic protein signaling: a turbulent relationship
Q27024905Current perspectives of the signaling pathways directing neural crest induction
Q36581497Current perspectives on the genetic causes of neural tube defects
Q47872928Decoupling brain from nerve cord development in the annelid Capitella teleta: Insights into the evolution of nervous systems.
Q38326590Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation
Q36708645Dentin phosphophoryn activates Smad protein signaling through Ca2+-calmodulin-dependent protein kinase II in undifferentiated mesenchymal cells
Q34579319Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.
Q41858943Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos
Q38080448Developmental mechanisms directing early anterior forebrain specification in vertebrates
Q42113611Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development.
Q35912796Dorsal-ventral patterning and neural induction in Xenopus embryos
Q43267901Downstream of FGF during mesoderm formation in Xenopus: the roles of Elk-1 and Egr-1.
Q37220058Drosophila Dullard functions as a Mad phosphatase to terminate BMP signaling
Q38240042Early embryonic specification of vertebrate cranial placodes
Q40803704Early neural crest induction requires an initial inhibition of Wnt signals.
Q24649140Effect of interleukin-1beta on osteogenic protein 1-induced signaling in adult human articular chondrocytes
Q48310408Epibranchial and otic placodes are induced by a common Fgf signal, but their subsequent development is independent
Q39821385Epicardium and myocardium separate from a common precursor pool by crosstalk between bone morphogenetic protein- and fibroblast growth factor-signaling pathways
Q38708405Epigenetic regulation of early neural fate commitment
Q35156067Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha
Q39284119Eukaryotic initiation factor eIF6 modulates the expression of Kermit 2/XGIPC in IGF- regulated eye development.
Q37907737Evo-devo: Hydra raises its Noggin
Q42440724Expression of insulin-like growth factor binding proteins during mouse cochlear development
Q41998199FGF signaling transforms non-neural ectoderm into neural crest.
Q24630591FGF signalling: diverse roles during early vertebrate embryogenesis
Q35624839FGF/MAPK signaling is required in the gastrula epiblast for avian neural crest induction
Q43636568FGF18 represses noggin expression and is induced by calcineurin
Q37967808FGFs: Neurodevelopment's Jack-of-all-Trades - How Do They Do it?
Q33269857Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b
Q38354513Fibroblast growth factor (FGF) signaling in development and skeletal diseases
Q37510049Fibroblast growth factor receptor 3 interacts with and activates TGFβ-activated kinase 1 tyrosine phosphorylation and NFκB signaling in multiple myeloma and bladder cancer
Q35590284Fibroblast growth factor regulates human neuroectoderm specification through ERK1/2-PARP-1 pathway
Q64098058Forskolin and IBMX Induce Neural Transdifferentiation of MSCs Through Downregulation of the NRSF
Q100503945Foxd4l1.1 negatively regulates transcription of neural repressor ventx1.1 during neuroectoderm formation in Xenopus embryos
Q37799089Functions of B56-containing PP2As in major developmental and cancer signaling pathways
Q46540576Gap junctions relay FGF8-mediated right-sided repression of Nodal in rabbit
Q36501132Genetic mechanisms mediating kisspeptin regulation of GnRH gene expression
Q39332689Genomic organization and modulation of gene expression of the TGF-β and FGF pathways in the allotetraploid frog Xenopus laevis
Q35570270High expression of BMP pathway genes distinguishes a subset of atypical teratoid/rhabdoid tumors associated with shorter survival
Q33210583High-throughput functional screen of mouse gastrula cDNA libraries reveals new components of endoderm and mesoderm specification
Q46460748Human platelet lysate successfully promotes proliferation and subsequent chondrogenic differentiation of adipose-derived stem cells: a comparison with articular chondrocytes
Q50529049IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro.
Q52033324Identification of a BMP inhibitor-responsive promoter module required for expression of the early neural gene zic1.
Q38295435Identification of microRNAs and microRNA targets in Xenopus gastrulae: The role of miR-26 in the regulation of Smad1.
Q28508517In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis
Q33358143Induction of Olig2 precursors by FGF involves BMP signalling blockade at the Smad level
Q46876717Influence of C-peptide on early glomerular changes in diabetic mice
Q50680663Inhibition of endothelial ERK signalling by Smad1/5 is essential for haematopoietic stem cell emergence.
Q36885432Initiation to end point: the multiple roles of fibroblast growth factors in neural development
Q42275283Insulin-Like Growth Factor II (IGF-II) Inhibits IL-1β-Induced Cartilage Matrix Loss and Promotes Cartilage Integrity in Experimental Osteoarthritis
Q35783772Insulin-like factor regulates neural induction through an IGF1 receptor-independent mechanism
Q24301688Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
Q37203477Integrating positional information at the level of Smad1/5/8.
Q33605524Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad.
Q30500268Interplay between FGF2 and BMP controls the self-renewal, dormancy and differentiation of rat neural stem cells
Q90662103Intracellular Communication among Morphogen Signaling Pathways during Vertebrate Body Plan Formation
Q44140808Jiraiya Attenuates BMP Signaling by Interfering with Type II BMP Receptors in Neuroectodermal Patterning
Q37492785Long-chain Acyl-CoA synthetase 4A regulates Smad activity and dorsoventral patterning in the zebrafish embryo
Q49905672MAPK and PI3K Signaling: at the Crossroads of Neural Crest Development.
Q36553050MAPK signalling: ERK5 versus ERK1/2.
Q33490999Mad is required for wingless signaling in wing development and segment patterning in Drosophila
Q34469350Mad linker phosphorylations control the intensity and range of the BMP-activity gradient in developing Drosophila tissues
Q37783809Making senses development of vertebrate cranial placodes
Q38612468Matters of context guide future research in TGFβ superfamily signaling
Q39873590Molecular stages of rapid and uniform neuralization of human embryonic stem cells
Q27320155Multiple signaling pathways coordinate to induce a threshold response in a chordate embryo
Q36729316Myelin repair: the role of stem and precursor cells in multiple sclerosis
Q37218550Neur-ons and neur-offs: regulators of neural induction in vertebrate embryos and embryonic stem cells
Q38117118Neural crest specification: tissues, signals, and transcription factors
Q38135361Neural induction and early patterning in vertebrates.
Q37596311Neural induction and factors that stabilize a neural fate
Q36804464Neural induction and neural stem cell development
Q80033357Neural induction in Xenopus requires inhibition of Wnt-beta-catenin signaling
Q24796653Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus
Q40718891Neural induction in the absence of organizer in salamanders is mediated by MAPK
Q30451424Neurodevelopmental effects of insulin-like growth factor signaling
Q21146059Notch promotes neural lineage entry by pluripotent embryonic stem cells
Q28505847Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation
Q24317164Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
Q45200175Olfactory and lens placode formation is controlled by the hedgehog-interacting protein (Xhip) in Xenopus
Q24796703Organizing the vertebrate embryo--a balance of induction and competence
Q34627291PDGF-AA promotes osteogenic differentiation and migration of mesenchymal stem cell by down-regulating PDGFRα and derepressing BMP-Smad1/5/8 signaling
Q36446405PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes
Q50643244PP2A:B56epsilon is required for eye induction and eye field separation.
Q35134407PV.1 induced by FGF-Xbra functions as a repressor of neurogenesis in Xenopus embryos
Q28511597Pax2 contributes to inner ear patterning and optic nerve trajectory
Q35547890Phosphorylation of Mad controls competition between wingless and BMP signaling
Q38844443Pin1, the Master Orchestrator of Bone Cell Differentiation
Q52659979Pitx1 regulates cement gland development in Xenopus laevis through activation of transcriptional targets and inhibition of BMP signaling.
Q37065225Point mutation of Hoxd12 in mice.
Q36856688Proposal of a model of mammalian neural induction
Q28474460Protein palmitoylation regulates osteoblast differentiation through BMP-induced osterix expression
Q42738349Recent advances in neural development
Q35652597Regulation of Smad activities
Q26827667Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads
Q52086104Regulation of bone morphogenetic proteins in early embryonic development.
Q37460835Regulation of neural specification from human embryonic stem cells by BMP and FGF.
Q42855703Regulation of neurogenesis by Fgf8a requires Cdc42 signaling and a novel Cdc42 effector protein
Q43207728Requirement of the MEK5-ERK5 pathway for neural differentiation in Xenopus embryonic development
Q37845215Role of BMP, FGF, calcium signaling, and Zic proteins in vertebrate neuroectodermal differentiation
Q48350022Role of bone morphogenetic proteins on cochlear hair cell formation: analyses of Noggin and Bmp2 mutant mice
Q38185993Roles for the TGFβ superfamily in the development and survival of midbrain dopaminergic neurons.
Q35996304SMOC Binds to Pro-EGF, but Does Not Induce Erk Phosphorylation via the EGFR.
Q92050316Salacia chinensis L. Stem Extract Exerts Antifibrotic Effects on Human Hepatic Stellate Cells Through the Inhibition of the TGF-β1-Induced SMAD2/3 Signaling Pathway
Q24303338Senataxin modulates neurite growth through fibroblast growth factor 8 signalling
Q36431499Sensory organs: making and breaking the pre-placodal region
Q38169872Setting appropriate boundaries: fate, patterning and competence at the neural plate border.
Q37361967Signal transduction of the physical environment in the neural differentiation of stem cells
Q33674328Smad signaling in skeletal development and regeneration
Q28506361Smad1 and Smad8 function similarly in mammalian central nervous system development.
Q38331197Smad1 expression and function during mouse embryonic lung branching morphogenesis
Q35837137Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor β (TGFβ)-mediated Germ Layer Induction in Xenopus Embryos
Q43014041Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension
Q36397987Sox3 expression is maintained by FGF signaling and restricted to the neural plate by Vent proteins in the Xenopus embryo
Q47726425Specific Preferences in Lineage Choice and Phenotypic Plasticity of Glioma Stem Cells Under BMP4 and Noggin Influence.
Q37958896Specification and regionalisation of the neural plate border.
Q38627019Specification of anteroposterior axis by combinatorial signaling during Xenopus development
Q52085741Specification of the enveloping layer and lack of autoneuralization in zebrafish embryonic explants.
Q59763033Specifying neural crest cells: From chromatin to morphogens and factors in between
Q35001381Spemann's organizer and the self-regulation of embryonic fields
Q30466690Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo
Q42180819Striatal Transplantation of Human Dopaminergic Neurons Differentiated From Induced Pluripotent Stem Cells Derived From Umbilical Cord Blood Using Lentiviral Reprogramming
Q28510905Stromal factors SDF1α, sFRP1, and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells
Q38341219Studying MAP Kinase Pathways During Early Development of Xenopus laevis
Q39107096TGF-β Family Signaling in Drosophila
Q39097023TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation
Q39107103TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function
Q34546546Tbx2 regulates anterior neural specification by repressing FGF signaling pathway
Q52032025Tcf- and Vent-binding sites regulate neural-specific geminin expression in the gastrula embryo.
Q26827564Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes
Q36806808Termination of TGF-beta superfamily signaling through SMAD dephosphorylation--a functional genomic view
Q50420456The Birth of the Eye Vesicle: When Fate Decision Equals Morphogenesis
Q64076028The Fine Tuning of Drp1-Dependent Mitochondrial Remodeling and Autophagy Controls Neuronal Differentiation
Q38001421The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation.
Q35154980The evolution of nervous system patterning: insights from sea urchin development
Q51852286The forkhead transcription factor FoxB1 regulates the dorsal-ventral and anterior-posterior patterning of the ectoderm during early Xenopus embryogenesis.
Q37381839The indirect role of fibroblast growth factor-8 in defining neurogenic niches of the olfactory/GnRH systems
Q37588577The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis
Q31120295The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42
Q34102091The response of early neural genes to FGF signaling or inhibition of BMP indicate the absence of a conserved neural induction module
Q37874928The role of Smad signaling in hematopoiesis and translational hematology
Q41990097The role of mechanical forces in the planar-to-bulk transition in growing Escherichia coli microcolonies.
Q50556857The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway.
Q26824939Transforming growth factor β signaling in uterine development and function
Q39883712Transforming growth factor-{beta}-inducible phosphorylation of Smad3
Q33302102Tsukushi modulates Xnr2, FGF and BMP signaling: regulation of Xenopus germ layer formation
Q35013177Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling
Q38782671Vertebrate Axial Patterning: From Egg to Asymmetry
Q50746171WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells.
Q36629761Wnt signaling in vertebrate axis specification
Q35671402Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus
Q90648860Xbra and Smad-1 cooperate to activate the transcription of neural repressor ventx1.1 in Xenopus embryos
Q38354490Xenopus SMOC-1 Inhibits bone morphogenetic protein signaling downstream of receptor binding and is essential for postgastrulation development in Xenopus
Q46132873Xenopus laevis as a Model Organism for the Study of Spinal Cord Formation, Development, Function and Regeneration
Q54372901Xenopus laevis insulin receptor substrate IRS-1 is important for eye development.
Q42020814Xmab21l3 mediates dorsoventral patterning in Xenopus laevis
Q52024209deltaEF1 and SIP1 are differentially expressed and have overlapping activities during Xenopus embryogenesis.
Q43138530dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity
Q33714231no tail integrates two modes of mesoderm induction

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