The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells.

scientific article published on 23 July 2004

The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M406639200
P698PubMed publication ID15277520

P50authorPhilip C. TrackmanQ40642250
Sebastien JeayQ73078896
P2093author name stringYing Guo
Amitha H Palamakumbura
Gail E Sonenshein
Nicole Pischon
Pascal Sommer
P2860cites workA technique for radiolabeling DNA restriction endonuclease fragments to high specific activityQ26778490
A new technique for the assay of infectivity of human adenovirus 5 DNAQ27860797
Bone morphogenetic protein-1: the type I procollagen C-proteinaseQ28115746
Gene switching by metabolic enzymes--how did you get on the invitation list?Q28190497
S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key componentQ28190509
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cellQ28208372
The activation of phosphatidylinositol 3-kinase by RasQ28305326
Fully processed lysyl oxidase catalyst translocates from the extracellular space into nuclei of aortic smooth-muscle cellsQ28568824
35 Lysyl oxidase: Preparation and role in elastin biosynthesisQ28610079
Metalloproteinase Activity Secreted by Fibrogenic Cells in the Processing of Prolysyl OxidaseQ29544584
Recruitment of enzymes as lens structural proteinsQ30473651
Isolation of genes specifically expressed in flat revertant cells derived from activated ras-transformed NIH 3T3 cells by treatment with azatyrosineQ33216759
Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequenceQ33500041
Ribosomal DNA: Molecular Evolution and Phylogenetic InferenceQ33845314
Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast culturesQ33943363
Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virusQ34253429
The role of collagen-derived proteolytic fragments in angiogenesisQ34375953
A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samplesQ34520249
Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B.Q34784159
Heparan sulfate proteoglycan as a plasma membrane carrierQ35084374
Suramin inhibits wound healing following filtering procedures for glaucomaQ35306077
Type IIA procollagen containing the cysteine-rich amino propeptide is deposited in the extracellular matrix of prechondrogenic tissue and binds to TGF-beta1 and BMP-2.Q36288339
Properties and Function of Lysyl OxidaseQ36520735
Interferon-induced revertants of ras-transformed cells: resistance to transformation by specific oncogenes and retransformation by 5-azacytidineQ36842359
Suramin, a novel antitumor compound.Q38031515
A role for lysyl oxidase regulation in the control of normal collagen deposition in differentiating osteoblast culturesQ40557286
Autocrine growth factor regulation of lysyl oxidase expression in transformed fibroblastsQ40642135
Down-regulation of lysyl oxidase-induced tumorigenic transformation in NRK-49F cells characterized by constitutive activation of ras proto-oncogeneQ40809856
Trimer carboxyl propeptide of collagen I produced by mature osteoblasts is chemotactic for endothelial cellsQ40864506
The osteoblastic MC3T3-E1 cells synthesized C-terminal propeptide of type I collagen, which promoted cell-attachment of osteoblastsQ41134762
Quantitative polymerase chain reaction of lysyl oxidase mRNA in malignantly transformed human cell lines demonstrates that their low lysyl oxidase activity is due to low quantities of its mRNA and low levels of transcription of the respective gene.Q41295028
Lysyl oxidase and rrg messenger RNA.Q41669222
Expression of Gene rrg Is Associated with Reversion of NIH 3Tt3 Transformed by LTR-c-H- rasQ41724661
Suramin in adrenal cancer: modulation of steroid hormone production, cytotoxicity in vitro, and clinical antitumor effect.Q41725624
Suramin therapy for patients with symptomatic hormone-refractory prostate cancer: results of a randomized phase III trial comparing suramin plus hydrocortisone to placebo plus hydrocortisoneQ41726848
Pre- and post-translational regulation of lysyl oxidase by transforming growth factor-beta 1 in osteoblastic MC3T3-E1 cellsQ42818962
The effect of carboxyl-terminal propeptide of type I collagen (c-propeptide) on collagen synthesis of preosteoblasts and osteoblastsQ42832951
Deficient production of lysyl oxidase in cultures of malignantly transformed human cells.Q53538666
The Complete Derived Amino Acid Sequence of Human Lysyl Oxidase and Assignment of the Gene to Chromosomes 5Q56593724
Molecular Characterisation of Integrin-Procollagen C-Propeptide InteractionsQ58058109
P433issue39
P407language of work or nameEnglishQ1860
P304page(s)40593-40600
P577publication date2004-07-23
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells
P478volume279

Reverse relations

cites work (P2860)
Q53176750A Polymorphism in the Lysyl Oxidase Propeptide Domain Accelerates Carcinogen-induced Cancer.
Q37312261A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer
Q24314451A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression
Q83920700Activation of cellular chemotactic responses to chemokines coupled with oxidation of plasma membrane proteins by lysyl oxidase
Q36367333Akbu-LAAO exhibits potent anti-tumor activity to HepG2 cells partially through produced H2O2 via TGF-β signal pathway
Q34070903Association of the G473A polymorphism and expression of lysyl oxidase with breast cancer risk and survival in European women: a hospital-based case-control study
Q34206164Blimp1 activation by AP-1 in human lung cancer cells promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptide
Q42853848Characterization of recombinant lysyl oxidase propeptide
Q34371559Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value in non-small cell lung cancer.
Q38841862Determination of cell uptake pathways for tumor inhibitor lysyl oxidase propeptide
Q61454345Divergent roles of lysyl oxidase family members in ornithine decarboxylase- and RAS-transformed mouse fibroblasts and human melanoma cells
Q36259191Diverse biological functions of extracellular collagen processing enzymes
Q38563638EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma.
Q90181271Effects of High Glucose-Induced Lysyl Oxidase Propeptide on Retinal Endothelial Cell Survival: Implications for Diabetic Retinopathy
Q38989588Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways
Q36923574Enzymatic and non-enzymatic functions of the lysyl oxidase family in bone
Q47584936Functional importance of lysyl oxidase family propeptide regions
Q40234158Habitual physical activity protects against lipopolysaccharide-induced inflammation in mouse adipose tissue
Q35821224High Lysyl Oxidase (LOX) in the Non-Malignant Prostate Epithelium Predicts a Poor Outcome in Prostate Cancer Patient Managed by Watchful Waiting
Q34355294High glucose increases lysyl oxidase expression and activity in retinal endothelial cells: mechanism for compromised extracellular matrix barrier function
Q39376172Human breast cancer cell metastasis is attenuated by lysyl oxidase inhibitors through down-regulation of focal adhesion kinase and the paxillin-signaling pathway
Q30009534Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide
Q40068242Inhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumour-Promoting and Tumour-Suppressing Roles in Experimental Prostate Cancer
Q64905661Inhibition of angiogenesis in endothelial cells by Human Lysyl oxidase propeptide.
Q58799743Insights into the structure and dynamics of lysyl oxidase propeptide, a flexible protein with numerous partners
Q40243976Intracellular distribution of the lysyl oxidase propeptide in osteoblastic cells
Q34303455LOXL2 in epithelial cell plasticity and tumor progression
Q37707030LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer
Q36404717Lysine post-translational modifications of collagen
Q51538665Lysyl Oxidase 473 G>A Polymorphism and Breast Cancer Susceptibility in Chinese Han Population
Q38723997Lysyl Oxidase Isoforms and Potential Therapeutic Opportunities for Fibrosis and Cancer
Q37631469Lysyl Oxidase and the Tumor Microenvironment
Q39224283Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype.
Q42720975Lysyl oxidase and enhancement of cell proliferation and angiogenesis in oral squamous cell carcinoma.
Q55176262Lysyl oxidase family members in urological tumorigenesis and fibrosis.
Q38134562Lysyl oxidase in colorectal cancer
Q34764399Lysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in Ewing sarcoma cells
Q38937873Lysyl oxidase isoforms in gastric cancer.
Q33748104Lysyl oxidase propeptide inhibits FGF-2-induced signaling and proliferation of osteoblasts
Q39825713Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling.
Q42005506Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation
Q38815129Lysyl oxidase propeptide promotes adipogenesis through inhibition of FGF-2 signaling
Q49277335Lysyl oxidase propeptide promotes adipogenesis through inhibition of FGF-2 signaling
Q37532942Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis
Q40251892Lysyl oxidase propeptide stimulates osteoblast and osteoclast differentiation and enhances PC3 and DU145 prostate cancer cell effects on bone in vivo
Q36126637Lysyl oxidase-like-1 enhances lung metastasis when lactate accumulation and monocarboxylate transporter expression are involved
Q28587970Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation
Q37812321Lysyl oxidase: a potential target for cancer therapy
Q28084024Mechanisms involved in breast cancer liver metastasis
Q35688339Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling
Q41694382Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients
Q34380963Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer
Q30156005Protein Biomarkers for in Vitro Testing of Embryotoxicity
Q28236828RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis
Q34170606Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts
Q34388063Retracted: Lysyl Oxidase Polymorphisms and Susceptibility to Osteosarcoma
Q37382550Role of lysyl oxidase propeptide in secretion and enzyme activity
Q34704924Silencing of hypoxia-inducible tumor suppressor lysyl oxidase gene by promoter methylation activates carbonic anhydrase IX in nasopharyngeal carcinoma.
Q34521147Structural ECM components in the premetastatic and metastatic niche
Q40434283Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1.
Q91823889The Extracellular Matrix Modulates the Metastatic Journey
Q28510648The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function
Q24301022The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells
Q37041619The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells
Q24307235The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits β-catenin transcriptional activity in lung cancer cells
Q38172108The potential for targeting extracellular LOX proteins in human malignancy
Q38027412The rationale for targeting the LOX family in cancer
Q35050472Transcriptome analysis of PPARγ target genes reveals the involvement of lysyl oxidase in human placental cytotrophoblast invasion
Q33292171UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells
Q37347497Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03.

Search more.