Functional importance of lysyl oxidase family propeptide regions

scientific article published on 30 October 2017

Functional importance of lysyl oxidase family propeptide regions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12079-017-0424-4
P932PMC publication ID5842187
P698PubMed publication ID29086201

P50authorPhilip C. TrackmanQ40642250
P2860cites workMolecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2Q24297537
The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cellsQ24301022
The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits β-catenin transcriptional activity in lung cancer cellsQ24307235
Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membraneQ24321781
The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene)Q28116452
RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasisQ28236828
Elastic fiber homeostasis requires lysyl oxidase-like 1 proteinQ28240976
The effect of lysyl oxidase polymorphism on susceptibility and prognosis of nonsmall cell lung cancerQ28274238
The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibersQ28279129
Metalloproteinase activity secreted by fibrogenic cells in the processing of prolysyl oxidase. Potential role of procollagen C-proteinaseQ28279434
Fully processed lysyl oxidase catalyst translocates from the extracellular space into nuclei of aortic smooth-muscle cellsQ28568824
Lysyl oxidase and P-ATPase-7A expression during embryonic development in the ratQ28577158
Metalloproteinase Activity Secreted by Fibrogenic Cells in the Processing of Prolysyl OxidaseQ29544584
Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptideQ30009534
Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancerQ33688524
Lysyl oxidase propeptide inhibits FGF-2-induced signaling and proliferation of osteoblastsQ33748104
Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast culturesQ33943363
Association of the G473A polymorphism and expression of lysyl oxidase with breast cancer risk and survival in European women: a hospital-based case-control studyQ34070903
Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenograftsQ34170606
Retracted: Lysyl Oxidase Polymorphisms and Susceptibility to OsteosarcomaQ34388063
Copper, lysyl oxidase, and extracellular matrix protein cross-linkingQ34468104
Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.Q34606497
Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B.Q34784159
Failure of elastic fiber homeostasis leads to pelvic floor disordersQ35087974
Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidaseQ35144992
Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signalingQ35688339
Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril AbnormalitiesQ36065087
Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissuesQ36085689
Loss of fibulin-4 disrupts collagen synthesis and maturation: implications for pathology resulting from EFEMP2 mutationsQ36089400
Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer.Q36265638
Lysyl oxidase-like protein from bovine aorta. Isolation and maturation to an active form by bone morphogenetic protein-1.Q43783344
Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven processQ44589382
Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavitiesQ44963178
Cellular fibronectin binds to lysyl oxidase with high affinity and is critical for its proteolytic activationQ46447933
Lysyl oxidase G473A polymorphism is associated with increased risk of ovarian cancerQ47853174
Alternative promoter activation leads to the expression of a novel human lysyl oxidase variant that functions as an amine oxidaseQ47993173
Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.Q50621871
Lysyl oxidase genetic variants and the prognosis of glioma.Q50916015
Lysyl Oxidase 473 G>A Polymorphism and Breast Cancer Susceptibility in Chinese Han PopulationQ51538665
Lysyl oxidase rs1800449 polymorphism and cancer risk among Asians: evidence from a meta-analysis and a case-control study of colorectal cancer.Q53232746
Loss of fibulin-4 results in abnormal collagen fibril assembly in bone, caused by impaired lysyl oxidase processing and collagen cross-linking.Q53236398
Deficient production of lysyl oxidase in cultures of malignantly transformed human cells.Q53538666
The Complete Derived Amino Acid Sequence of Human Lysyl Oxidase and Assignment of the Gene to Chromosomes 5Q56593724
Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assemblyQ73821744
Decreased expression of elastin, fibulin-5 and lysyl oxidase-like 1 in the uterosacral ligaments of postmenopausal women with pelvic organ prolapseQ83839482
Association between lysyl oxidase G473A polymorphism and ovarian cancer in the Han Chinese populationQ84828227
Lysyl oxidase genetic variants affect gene expression in cervical cancerQ88111215
Uncovering the role of nuclear Lysyl oxidase (LOX) in advanced high grade serous ovarian cancerQ36369565
Periostin is essential for cardiac healing after acute myocardial infarctionQ36502829
Properties and Function of Lysyl OxidaseQ36520735
Localization and activity of lysyl oxidase within nuclei of fibrogenic cellsQ36709638
Enzymatic and non-enzymatic functions of the lysyl oxidase family in boneQ36923574
The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cellsQ37041619
Lysyl Oxidase Gene G473A Polymorphism and Cigarette Smoking in Association with a High Risk of Lung and Colorectal Cancers in a North Chinese PopulationQ37128746
A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancerQ37312261
Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distributionQ37362619
Fibronectin binds and enhances the activity of bone morphogenetic protein 1.Q37377705
Role of lysyl oxidase propeptide in secretion and enzyme activityQ37382550
Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidaseQ37419190
Human copper-dependent amine oxidases.Q38177145
Human lysyl oxidase-like 2.Q38242121
Targeting RAS-ERK signalling in cancer: promises and challengesQ38272894
Alternatively spliced lysyl oxidase-like 4 isoforms have a pro-metastatic role in cancerQ38323507
Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitorQ38344322
Proteolytic Processing of Lysyl Oxidase like-2 in the Extracellular Matrix is Required for Crosslinking of Basement Membrane Collagen IV.Q38597172
Lysyl Oxidase Isoforms and Potential Therapeutic Opportunities for Fibrosis and CancerQ38723997
TGF-β1 promotes linear invadosome formation in hepatocellular carcinoma cells, through DDR1 up-regulation and collagen I cross-linkingQ38741926
Determination of cell uptake pathways for tumor inhibitor lysyl oxidase propeptideQ38841862
Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma.Q38973071
Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathwaysQ38989588
Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase.Q39735458
Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling.Q39825713
LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancerQ40141667
Intracellular distribution of the lysyl oxidase propeptide in osteoblastic cellsQ40243976
Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.Q40514759
The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells.Q40531209
The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiationQ40811068
Post-translational glycosylation and proteolytic processing of a lysyl oxidase precursor.Q41628295
Lysyl oxidase and rrg messenger RNA.Q41669222
Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patientsQ41694382
Expression of Gene rrg Is Associated with Reversion of NIH 3Tt3 Transformed by LTR-c-H- rasQ41724661
LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition.Q41957208
ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis.Q42118077
LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathwayQ42314655
The proteolytic processing site of the precursor of lysyl oxidase.Q42824263
Characterization of recombinant lysyl oxidase propeptideQ42853848
Lysyl oxidase G473A polymorphism is closely associated with susceptibility to gastric cancer in a South Korean populationQ43469688
P433issue1
P304page(s)45-53
P577publication date2017-10-30
P1433published inJournal of Cell Communication and SignalingQ26841964
P1476titleFunctional importance of lysyl oxidase family propeptide regions
P478volume12

Reverse relations

cites work (P2860)
Q92945329A Three-Dimensional Model of Human Lysyl Oxidase, a Cross-Linking Enzyme
Q52729957Endoglin haploinsufficiency is associated with differential regulation of extracellular matrix production during skin fibrosis and cartilage repair in mice.
Q89477379Grains
Q58799743Insights into the structure and dynamics of lysyl oxidase propeptide, a flexible protein with numerous partners
Q92845923Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress
Q58763545Lysyl oxidase (LOX) limits VSMC proliferation and neointimal thickening through its extracellular enzymatic activity

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