The Paradox of Immune Molecular Recognition of α-Galactosylceramide: Low Affinity, Low Specificity for CD1d, High Affinity for αβ TCRs

scientific article published on May 1, 2003

The Paradox of Immune Molecular Recognition of α-Galactosylceramide: Low Affinity, Low Specificity for CD1d, High Affinity for αβ TCRs is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.170.9.4673
P8608Fatcat IDrelease_hsf3qvaywvee7if3u6wligmmmy
P953full work available at URLhttps://journals.aai.org/jimmunol/article-pdf/170/9/4673/1164665/4673.pdf
P698PubMed publication ID12707346
P5875ResearchGate publication ID10794742

P50authorKamel BenlaghaQ92623701
P2093author name stringAlbert Bendelac
Luc Teyton
Carlos Cantu
Paul B. Savage
P2860cites workBinding and antigen presentation of ceramide-containing glycolipids by soluble mouse and human CD1d moleculesQ22010665
A comparative analysis of the immunological evolution of antibody 28B4Q27634671
Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding grooveQ27729958
Structural insights into the evolution of an antibody combining siteQ27738883
Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding grooveQ27740401
Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteinsQ28203695
CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramidesQ28254991
Structure and function of the human MHC class Ib molecules HLA-E, HLA-F and HLA-GQ28279282
CD1 recognition by mouse NK1+ T lymphocytesQ28591238
The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binderQ30919440
Binding of two mono-acylated lipid monomers by the barley lipid transfer protein, LTP1, as viewed by fluorescence, isothermal titration calorimetry and molecular modellingQ31896630
Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol.Q32105308
The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipidsQ33652486
CD1 and lipid antigens: intracellular pathways for antigen presentationQ34129382
Development and selection of NKT cellsQ34547258
Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanningQ35651348
Molecular recognition of lipid antigens by T cell receptorsQ35834577
Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitisQ36237629
Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antiseraQ36247967
Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cellsQ36348048
An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.Q36363643
Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II moleculesQ36366719
Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramersQ36368804
The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor familiesQ36369224
CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation.Q36369627
CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolutionQ36404242
In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramersQ36404648
Structural requirements for antigen presentation by mouse CD1Q37421040
On the dynamics of TCR:CD3 complex cell surface expression and downmodulationQ40837872
Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs.Q40848434
Cutting edge: the IgG response to the circumsporozoite protein is MHC class II-dependent and CD1d-independent: exploring the role of GPIs in NK T cell activation and antimalarial responsesQ40881646
Murine CD1d-restricted T cell recognition of cellular lipidsQ40894441
Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartmentsQ41785389
CD1d-glycolipid tetramers: A new tool to monitor natural killer T cells in health and diseaseQ42944243
Molecular interaction of CD1b with lipoglycan antigensQ43559521
Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1dQ43814667
Lipid protein interactions: the assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulumQ43845866
Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentationQ43950987
Ligand recognition by alpha beta T cell receptorsQ46222293
Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6"-amino-6"-deoxy-galactosylceramidesQ50201726
The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex.Q52116949
Exposure of tryptophanyl residues in proteins. Quantitative determination by fluorescence quenching studiesQ52858382
Protein−Protein Interactions: Interface Structure, Binding Thermodynamics, and Mutational AnalysisQ58044062
Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chainsQ60311710
A population of murine gammadelta T cells that recognize an inducible MHC class Ib moleculeQ73352533
TCR binding to peptide-MHC stabilizes a flexible recognition interfaceQ77328526
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
P304page(s)4673-4682
P577publication date2003-05-01
P1433published inJournal of ImmunologyQ3521441
P1476titleThe paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs
The Paradox of Immune Molecular Recognition of α-Galactosylceramide: Low Affinity, Low Specificity for CD1d, High Affinity for αβ TCRs
P478volume170

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cites work (P2860)
Q27667172A Molecular Basis for NKT Cell Recognition of CD1d-Self-Antigen
Q36228473A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.
Q37433546Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands
Q33745321Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells
Q35798146Antigen specificity of semi-invariant CD1d-restricted T cell receptors: the best of both worlds?
Q88433965Are fat NKT cells born that way?
Q43143368Beta-glycoglycosphingolipid-induced alterations of the STAT signaling pathways are dependent on CD1d and the lipid raft protein flotillin-2.
Q33695019CD1: A Singed Cat of the Three Antigen Presentation Systems.
Q27646101CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor
Q37207409CD1d-restricted glycolipid antigens: presentation principles, recognition logic and functional consequences
Q37548658Carbohydrate specificity of the recognition of diverse glycolipids by natural killer T cells
Q36858868Control points in NKT-cell development
Q27662107Crystal Structure of Bovine CD1b3 with Endogenously Bound Ligands
Q27649921Crystal Structures of Mouse CD1d-iGb3 Complex and its Cognate Vα14 T Cell Receptor Suggest a Model for Dual Recognition of Foreign and Self Glycolipids
Q35850913Cutting edge: dendritic epidermal γδ T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding
Q34053547Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins.
Q34972844Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b
Q37040200Expression of CD1c enhances human invariant NKT cell activation by α-GalCer
Q33882880Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice
Q46836645Fine specificity of natural killer T cells against GD3 ganglioside and identification of GM3 as an inhibitory natural killer T-cell ligand
Q56917232Germline-encoded recognition of diverse glycolipids by natural killer T cells
Q37187603Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants
Q36517889Glycolipids as immunostimulating agents
Q39859712Human CD1 dimeric proteins as indispensable tools for research on CD1-binding lipids and CD1-restricted T cells
Q36990616Innate Valpha14(+) natural killer T cells mature dendritic cells, leading to strong adaptive immunity
Q37986831Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells
Q38883497Invariant natural killer T cells: front line fighters in the war against pathogenic microbes
Q27658982Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells
Q28592914Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved
Q27677869Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor
Q37902828NKT cell ligand recognition logic: molecular basis for a synaptic duet and transmission of inflammatory effectors
Q42954809Potential role of NKT regulatory cell ligands for the treatment of immune mediated colitis
Q35684305Quantitative microarray analysis of intact glycolipid-CD1d interaction and correlation with cell-based cytokine production
Q33512901Recognition of lyso-phospholipids by human natural killer T lymphocytes
Q35914938Regulation of immune responses by CD1d-restricted natural killer T cells
Q88112593Role of lipid transfer proteins in loading CD1 antigen-presenting molecules
Q35850396Species Specific Differences of CD1d Oligomer Loading In Vitro
Q27659192Structural Basis for Lipid-Antigen Recognition in Avian Immunity
Q36300615Structural features of the acyl chain determine self-phospholipid antigen recognition by a CD1d-restricted invariant NKT (iNKT) cell
Q36228456Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors
Q24672186Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor
Q35953645Survey of the year 2003 commercial optical biosensor literature
Q37994621T cells specific for lipid antigens
Q92623707TCR density in early iNKT cell precursors regulates agonist selection and subset differentiation in mice
Q37995950Targeting natural killer cells and natural killer T cells in cancer
Q24317551The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation
Q36229257The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells
Q37484801The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition
Q35798152The Third Way: Progress on pathways of antigen processing and presentation by CD1.
Q27664892The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode
Q34328138The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells
Q33843406The stimulating adventure of KRN 7000.
Q36229651Thymic selection pathway regulates the effector function of CD4 T cells
Q27670856Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens
Q35557428Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity
Q35998799alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles

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