Deletion of penton RGD motifs affects the efficiency of both the internalization and the endosome escape of viral particles containing adenovirus serotype 5 or 35 fiber knobs

scientific article published on January 2005

Deletion of penton RGD motifs affects the efficiency of both the internalization and the endosome escape of viral particles containing adenovirus serotype 5 or 35 fiber knobs is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.79.2.1053-1061.2005
P932PMC publication ID538548
P698PubMed publication ID15613334
P5875ResearchGate publication ID8117676

P2093author name stringAndré Lieber
Zong-Yi Li
Dmitry M Shayakhmetov
Andrea M Eberly
P2860cites workIntegrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachmentQ29615852
The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3Q33201422
Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vectorQ33799667
Fiber swap between adenovirus subgroups B and C alters intracellular trafficking of adenovirus gene transfer vectors.Q33815931
A high-capacity, capsid-modified hybrid adenovirus/adeno-associated virus vector for stable transduction of human hematopoietic cellsQ34329158
Intact microtubules support adenovirus and herpes simplex virus infectionsQ34347524
Loss of adenoviral receptor expression in human bladder cancer cells: a potential impact on the efficacy of gene therapy.Q34490270
Molecular basis of the inflammatory response to adenovirus vectorsQ35131213
Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: efficient human cell infection and bypass of preexisting adenovirus immunityQ35155049
Endocytosis of adenovirus and adenovirus capsid proteinsQ35575300
The role of the adenovirus protease on virus entry into cellsQ35847676
Microtubule-dependent plus- and minus end-directed motilities are competing processes for nuclear targeting of adenovirusQ36255836
Expression of membrane cofactor protein (MCP, CD46) in human liver diseasesQ36640857
Mutations that alter an Arg-Gly-Asp (RGD) sequence in the adenovirus type 2 penton base protein abolish its cell-rounding activity and delay virus reproduction in flat cellsQ36651749
Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitisQ37093465
Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB.Q38304862
Flexibility of the adenovirus fiber is required for efficient receptor interactionQ38353615
The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and FQ39581053
Dependence of adenovirus infectivity on length of the fiber shaft domainQ39585255
Adenovirus serotype 7 retention in a late endosomal compartment prior to cytosol escape is modulated by fiber proteinQ39601931
Integrin alpha(v)beta1 is an adenovirus coreceptorQ39606281
The interaction between the fiber knob domain and the cellular attachment receptor determines the intracellular trafficking route of adenovirusesQ39732535
Adenovirus type 11 uses CD46 as a cellular receptorQ39864028
Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cellsQ39875151
Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli.Q39875310
Integrin alpha5beta1-mediated adenovirus infection is enhanced by the integrin-activating antibody TS2/16Q39880664
Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins.Q39882081
Genome size and structure determine efficiency of postinternalization steps and gene transfer of capsid-modified adenovirus vectors in a cell-type-specific mannerQ39960246
Human adenovirus type 35: nucleotide sequence and vector developmentQ40628840
Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in miceQ40640134
Adenovirus vector-induced inflammation: capsid-dependent induction of the C-C chemokine RANTES requires NF-kappa B.Q40658021
Genetic manipulations of adenovirus type 5 fiber resulting in liver tropism attenuationQ40672499
Adenovirus vectors containing chimeric type 5 and type 35 fiber proteins exhibit altered and expanded tropism and increase the size limit of foreign genesQ40728508
Rearrangements in adenoviral genomes mediated by inverted repeatsQ40746282
Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectorsQ40815226
Improved production of adenovirus vectors expressing apoptotic transgenesQ40904103
Maturation of dendritic cells accompanies high-efficiency gene transfer by a CD40-targeted adenoviral vectorQ40951294
Fluorescent virions: dynamic tracking of the pathway of adenoviral gene transfer vectors in living cellsQ41057879
Levels of complement regulatory proteins, CD35 (CR1), CD46 (MCP) and CD55 (DAF) in human haematological malignanciesQ41094406
Adenovirus type 5 uptake by lung adenocarcinoma cells in culture correlates with Ad5 fibre binding is mediated by alpha(v)beta1 integrin and can be modulated by changes in beta1 integrin functionQ43846282
MAP kinases and NF-kappaB collaborate to induce ICAM-1 gene expression in the early phase of adenovirus infectionQ44384901
Efficient gene transfer into human CD34+ cells by an adenovirus type 35 vectorQ45862548
CD46 is a cellular receptor for group B adenovirusesQ45869560
Maturation and lineage-specific expression of the coxsackie and adenovirus receptor in hematopoietic cells.Q50107523
Adenovirus endocytosisQ64377623
Targeting of adenovirus vectors to tumor cells does not enable efficient transduction of breast cancer metastasesQ64379110
Adenovirus entry into host cells: a role for alpha(v) integrinsQ64383600
Expression of complement regulatory proteins-CD 35, CD 46, CD 55, and CD 59-in benign and malignant endometrial tissueQ73358283
The complement regulatory proteins CD46 and CD59, but not CD55, are highly expressed by glandular epithelium of human breast and colorectal tumour tissuesQ77531394
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
P304page(s)1053-1061
P577publication date2005-01-01
P1433published inJournal of VirologyQ1251128
P1476titleDeletion of penton RGD motifs affects the efficiency of both the internalization and the endosome escape of viral particles containing adenovirus serotype 5 or 35 fiber knobs
P478volume79

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cites work (P2860)
Q49963933A novel fiber chimeric conditionally replicative adenovirus-Ad5/F35 for tumor therapy
Q38305480Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop
Q30375982Adenovirus as a carrier for the development of influenza virus-free avian influenza vaccines.
Q33984229Adenovirus receptors
Q33994011Adenovirus receptors and their implications in gene delivery
Q36535456Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo
Q40297306Adenovirus type 5 interactions with human blood cells may compromise systemic delivery.
Q35156188Adenoviruses using the cancer marker EphA2 as a receptor in vitro and in vivo by genetic ligand insertion into different capsid scaffolds
Q40246202Analysis of the interaction between RGD-expressing adenovirus type 5 fiber knob domains and alphavbeta3 integrin reveals distinct binding profiles and intracellular trafficking.
Q42174783At the Frontier; RXLR Effectors Crossing the Phytophthora-Host Interface.
Q38576959Beyond RGD: virus interactions with integrins.
Q39558860Cell specific peptide-conjugated polysaccharide nanogels for protein delivery
Q33690982Chemical modification with high molecular weight polyethylene glycol reduces transduction of hepatocytes and increases efficacy of intravenously delivered oncolytic adenovirus
Q38233232Coat as a dagger: the use of capsid proteins to perforate membranes during non-enveloped DNA viruses trafficking.
Q41847338Contrasting effects of human, canine, and hybrid adenovirus vectors on the phenotypical and functional maturation of human dendritic cells: implications for clinical efficacy
Q36463004Current advances and future challenges in Adenoviral vector biology and targeting
Q37241434DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice.
Q43555422Dendritic cell function after gene transfer with adenovirus-calcium phosphate co-precipitates
Q36318182Development of transcriptionally regulated oncolytic adenoviruses
Q39915885Differential role of alpha(v)beta(3) and alpha(v)beta(5) integrins in internalization and transduction efficacies of wild type and RGD4C fiber-modified adenoviruses
Q35016982Effect of adenoviral delivery of prodynorphin gene on experimental inflammatory pain induced by formalin in rats
Q35926041Engineered phage-based therapeutic materials inhibit Chlamydia trachomatis intracellular infection
Q33364166Enhanced core hydrophobicity, functionalization and cell penetration of polybasic nanomatrices
Q36315434Fiber shaft-chimeric adenovirus vectors lacking the KKTK motif efficiently infect liver cells in vivo
Q40025937Growth characteristics of human adenoviruses on porcine cell lines
Q36607369Host cell autophagy modulates early stages of adenovirus infections in airway epithelial cells
Q38726189Human Adenovirus Type 37 Uses αVβ1 and α3β1 Integrins for Infection of Human Corneal Cells
Q36098980Identification of HI-like loop in CELO adenovirus fiber for incorporation of receptor binding motifs.
Q40273729Improved gene delivery to B lymphocytes using a modified adenovirus vector targeting CD21.
Q33234748Improved gene delivery to intestinal mucosa by adenoviral vectors bearing subgroup B and d fibers
Q39946508In vitro and in vivo properties of adenovirus vectors with increased affinity to CD46
Q36681507Influence of cell physiological state on gene delivery to T lymphocytes by chimeric adenovirus Ad5F35.
Q39502394Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors
Q36852526Integrin Receptors Play a Key Role in the Regulation of Hepatic CYP3A.
Q110951933Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2
Q40084250Interaction of penton base Arg-Gly-Asp motifs with integrins is crucial for adenovirus serotype 35 vector transduction in human hematopoietic cells
Q40090939Intracellular trafficking of a fiber-modified adenovirus using lipid raft/caveolae endocytosis
Q37438361Limitations of Adenoviral Vector-Mediated Delivery of Gold Nanoparticles to Tumors for Hyperthermia Induction
Q33275292Mechanism of ad5 vaccine immunity and toxicity: fiber shaft targeting of dendritic cells
Q48144871Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery
Q26776553Oncolytic Adenovirus: Strategies and Insights for Vector Design and Immuno-Oncolytic Applications
Q36318189Oncolytic adenoviruses - selective retargeting to tumor cells
Q33713401Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver
Q28475714Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X
Q42208596Retinal transduction profiles by high-capacity viral vectors
Q45873308Significant alterations of biodistribution and immune responses in Balb/c mice administered with adenovirus targeted to CD40(+) cells
Q45870768Successful target cell transduction of capsid-engineered rAAV vectors requires clathrin-dependent endocytosis
Q92622099Targeting Antigen to the Surface of EVs Improves the In Vivo Immunogenicity of Human and Non-human Adenoviral Vaccines in Mice
Q33275168Targeting of adenovirus vectors carrying a tumor cell-specific peptide: in vitro and in vivo studies
Q40774340The Intracellular Domain of the Coxsackievirus and Adenovirus Receptor Differentially Influences Adenovirus Entry.
Q45856648The effect of hypoxia on the uptake, replication and lytic potential of group B adenovirus type 3 (Ad3) and type 11p (Ad11p).
Q38230901The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery
Q33382953Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy.
Q59354245Tropism and transduction of oncolytic adenovirus 5 vectors in cancer therapy: Focus on fiber chimerism and mosaicism, hexon and pIX
Q40189728Tropism modification of adenovirus vectors by peptide ligand insertion into various positions of the adenovirus serotype 41 short-fiber knob domain
Q91768182Unravelling Receptor and RGD Motif Dependence of Retargeted Adenoviral Vectors using Advanced Tumor Model Systems
Q42579980Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
Q36716644iTRAQ-Based and Label-Free Proteomics Approaches for Studies of Human Adenovirus Infections

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