Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor alpha or 1-methyl-4-phenylpyridinium treatment

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Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor alpha or 1-methyl-4-phenylpyridinium treatment is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0169-328X(01)00216-9
P698PubMed publication ID11731015

P2093author name stringMitchell V
Pierce A
Benaïssa M
Fillebeen C
Ruchoux MM
Vincent S
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Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson diseaseQ33856488
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Neutrophil degranulation inhibits potential hydroxyl-radical formation. Relative impact of myeloperoxidase and lactoferrin release on hydroxyl-radical production by iron-supplemented neutrophils assessed by spin-trapping techniquesQ42151128
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The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysisQ48090510
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Lactoferrin is synthesized by mouse brain tissue and its expression is enhanced after MPTP treatmentQ64854159
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Lactoferrin, C-reactive protein, alpha-1-antitrypsin and immunoglobulin GA in cerebrospinal fluid in meningitisQ68804677
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Production of tumor necrosis factor-alpha by microglia and astrocytes in cultureQ69693619
Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease casesQ71469541
Antioxidant action of neuromelanin: the mechanism of inhibitory effect on lipid peroxidationQ72289910
Lactoferrin, lysozyme, and beta 2-microglobulin in cerebrospinal fluid. Elevated levels in patients with acute cerebrovascular lesions as indices of inflammationQ72632686
Tumor necrosis factor-alpha increases lactoferrin transcytosis through the blood-brain barrierQ73229643
[Preparation and properties of lactosiderophilin (lactotransferrin) of human milk]Q79076068
P433issue1-2
P921main subjectsubstantia nigraQ753278
microgliaQ1622829
P304page(s)103-113
P577publication date2001-11-01
P1433published inMolecular Brain ResearchQ6895939
P1476titleLactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor alpha or 1-methyl-4-phenylpyridinium treatment
P478volume96

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cites work (P2860)
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Q36745818Immunomodulatory effects of lactoferrin
Q47708680Integrin alpha 10, CD44, PTEN, cadherin-11 and lactoferrin expressions are potential biomarkers for selecting patients in need of central nervous system prophylaxis in diffuse large B-cell lymphoma
Q50462329Intranasal Lactoferrin Enhances α-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1α Pathways in an Alzheimer's Disease Mouse Model
Q64076840Iron in Neurodegeneration - Cause or Consequence?
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Q44342186Lactoferrin elicits opioid-mediated antinociception without development of tolerance: central nNOS-1 set off duty?
Q44341191Lactoferrin enhances opioid-mediated analgesia via nitric oxide in the rat spinal cord
Q49324255New Progress on the Role of Glia in Iron Metabolism and Iron-Induced Degeneration of Dopamine Neurons in Parkinson's Disease
Q44318946Novel function of bovine milk-derived lactoferrin on antinociception mediated by mu-opioid receptor in the rat spinal cord
Q35673103The protective effect of lactoferrin on ventral mesencephalon neurons against MPP + is not connected with its iron binding ability

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