A Recombinant G Protein Plus Cyclosporine A-Based Respiratory Syncytial Virus Vaccine Elicits Humoral and Regulatory T Cell Responses against Infection without Vaccine-Enhanced Disease

scientific article published on 20 January 2016

A Recombinant G Protein Plus Cyclosporine A-Based Respiratory Syncytial Virus Vaccine Elicits Humoral and Regulatory T Cell Responses against Infection without Vaccine-Enhanced Disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1502103
P698PubMed publication ID26792805

P50authorChaofan LiQ96205055
P2093author name stringBin Wang
Changgui Li
Xian Zhou
Yiwei Zhong
Shuren Zhang
Aihua Dong
Zhonghuai He
P2860cites workCrystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexesQ24535752
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Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory diseaseQ36229433
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Effect of rapamycin on the cyclosporin A-resistant CD28-mediated costimulatory pathwayQ44010408
Tacrolimus and cyclosporine differ in their capacity to overcome ongoing allograft rejection as a result of their differential abilities to inhibit interleukin-10 productionQ44042070
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Respiratory syncytial virus and neutrophil activationQ45454401
Anti-G protein antibody responses to respiratory syncytial virus infection or vaccination are associated with inhibition of G protein CX3C-CX3CR1 binding and leukocyte chemotaxisQ45553949
The small hydrophobic (SH) protein accumulates within lipid-raft structures of the Golgi complex during respiratory syncytial virus infectionQ45648966
Interleukin-12 Treatment during Immunization Elicits a T Helper Cell Type 1-like Immune Response in Mice Challenged with Respiratory Syncytial Virus and Improves Vaccine ImmunogenicityQ45787389
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Low-dose cyclosporine A therapy increases the regulatory T cell population in patients with atopic dermatitis.Q47828390
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Induction of adaptive T regulatory cells that suppress the allergic response by coimmunization of DNA and protein vaccines.Q52690110
B cell resistance to Fas-mediated apoptosis contributes to their ineffective control by regulatory T cells in rheumatoid arthritis.Q53082574
Naturally occurring lung CD4(+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta.Q53576197
Peripheral CD4+ CD25+ Treg cell expansion in lung transplant recipients is not affected by calcineurin inhibitorsQ58910606
Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virusQ36355326
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Long-term cultured CD40-activated B lymphocytes differentiate into plasma cells in response to IL-10 but not IL-4.Q36672108
Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthmaQ36810987
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The respiratory syncytial virus fusion protein and neutrophils mediate the airway mucin response to pathogenic respiratory syncytial virus infectionQ37123113
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Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in miceQ37252618
Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells.Q37346143
Cell cycle arrest by transforming growth factor beta1 enhances replication of respiratory syncytial virus in lung epithelial cellsQ37451996
Immunosuppressive drugs and Tregs: a critical evaluation!Q37583262
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Fatality rates in published reports of RSV hospitalizations among high-risk and otherwise healthy childrenQ37776266
Homeostatic control of regulatory T cell diversity.Q38183674
Cyclophilin inhibition as potential therapy for liver diseasesQ38232505
Respiratory Syncytial Virus: pathology, therapeutic drugs and prophylaxis.Q38255545
Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-kappaB-dependent, interferon-independent mechanism and facilitate virus growthQ40199774
Cyclophilin A-deficient mice are resistant to immunosuppression by cyclosporineQ40425586
Two distinct action mechanisms of immunophilin-ligand complexes for the blockade of T-cell activationQ40606038
An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccineQ40940832
The mechanism of action of cyclosporin A and FK506.Q41114675
Factors associated with early remission of type I diabetes in children treated with cyclosporineQ41282880
Respiratory syncytial virus G protein CX3C motif impairs human airway epithelial and immune cell responsesQ41838015
Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cellsQ41872700
Motavizumab treatment of infants hospitalized with respiratory syncytial virus infection does not decrease viral load or severity of illness.Q42248000
Systemic eosinophil response induced by respiratory syncytial virusQ42496152
Synergistic Bcl-2 inhibition by ABT-737 and cyclosporine A.Q42517322
Influence of combined treatment of low dose rapamycin and cyclosporin A on corneal allograft survivalQ43007021
Rapamycin, unlike cyclosporine A, enhances suppressive functions of in vitro-induced CD4+CD25+ TregsQ43244822
B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretionQ43418649
Efficient lung recruitment of respiratory syncytial virus-specific Th1 cells induced by recombinant bacillus Calmette-Guérin promotes virus clearance and protects from infectionQ43610628
Sanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of actionQ43628930
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcyclosporineQ367700
P304page(s)1721-1731
P577publication date2016-01-20
P1433published inJournal of ImmunologyQ3521441
P1476titleA Recombinant G Protein Plus Cyclosporine A-Based Respiratory Syncytial Virus Vaccine Elicits Humoral and Regulatory T Cell Responses against Infection without Vaccine-Enhanced Disease
P478volume196

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cites work (P2860)
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Q91881931Tolerogenic vaccine composited with islet-derived multipeptides and cyclosporin A induces pTreg and prevents Type 1 diabetes in murine model
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