Prophylaxis with a respiratory syncytial virus (RSV) anti-G protein monoclonal antibody shifts the adaptive immune response to RSV rA2-line19F infection from Th2 to Th1 in BALB/c mice

scientific article

Prophylaxis with a respiratory syncytial virus (RSV) anti-G protein monoclonal antibody shifts the adaptive immune response to RSV rA2-line19F infection from Th2 to Th1 in BALB/c mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.01503-14
P932PMC publication ID4178873
P698PubMed publication ID24990999

P50authorSeyhan Boyoglu-BarnumQ106368738
Lia M HaynesQ106464754
Ralph A. TrippQ45349521
Larry J. AndersonQ61046798
P2093author name stringMartin L Moore
Kelsey A Gaston
Patricia Jorquera
Sean O Todd
Tatiana Chirkova
Thomas R Barnum
P2860cites workGlobal and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010Q21534928
A novel transcription factor, T-bet, directs Th1 lineage commitmentQ22253874
TCR-dependent translational control of GATA-3 enhances Th2 differentiationQ28290084
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammationQ28584806
Control of inflammation, cytokine expression, and germinal center formation by BCL-6Q28585541
Inhibition of Th2 differentiation and GATA-3 expression by BCL-6Q28594529
Follicular helper CD4 T cells (TFH)Q29615063
Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysisQ29619821
The attachment (G) glycoprotein of respiratory syncytial virus contains a single immunodominant epitope that elicits both Th1 and Th2 CD4+ T cell responses.Q30306426
Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2.Q30425776
Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virusQ30431134
Respiratory syncytial virus G and/or SH protein alters Th1 cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB/c mice.Q33648461
Conserved cysteine residues within the attachment G glycoprotein of respiratory syncytial virus play a critical role in the enhancement of cytotoxic T-lymphocyte responsesQ33754172
Effects of human respiratory syncytial virus, metapneumovirus, parainfluenza virus 3 and influenza virus on CD4+ T cell activation by dendritic cellsQ33760691
Respiratory syncytial virus infection and G and/or SH protein expression contribute to substance P, which mediates inflammation and enhanced pulmonary disease in BALB/c miceQ33797058
Respiratory syncytial virus G and/or SH glycoproteins modify CC and CXC chemokine mRNA expression in the BALB/c mouseQ33807265
The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxinQ33863111
Treatment with respiratory syncytial virus G glycoprotein monoclonal antibody or F(ab')2 components mediates reduced pulmonary inflammation in miceQ33920501
CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infectionQ34055489
CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lungQ82244974
Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infectionQ34072674
Prophylactic treatment with a G glycoprotein monoclonal antibody reduces pulmonary inflammation in respiratory syncytial virus (RSV)-challenged naive and formalin-inactivated RSV-immunized BALB/c mice.Q34120278
IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in miceQ34185860
Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccineQ34206177
Respiratory syncytial virus infection in elderly and high-risk adultsQ34414401
Biological challenges and technological opportunities for respiratory syncytial virus vaccine developmentQ34504791
Therapeutic targeting of respiratory syncytial virus G-protein.Q34603346
Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virusQ34647754
The cysteine-rich region and secreted form of the attachment G glycoprotein of respiratory syncytial virus enhance the cytotoxic T-lymphocyte response despite lacking major histocompatibility complex class I-restricted epitopesQ34651258
CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responsesQ34726022
IFN-α as an Adjuvant for Adenovirus-Vectored FMDV Subunit Vaccine through Improving the Generation of T Follicular Helper CellsQ34792464
Nanoparticle vaccines encompassing the respiratory syncytial virus (RSV) G protein CX3C chemokine motif induce robust immunity protecting from challenge and diseaseQ34990420
The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance P.Q34996665
Germinal center B cell and T follicular helper cell development initiates in the interfollicular zoneQ35758747
Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infectionQ35831296
Pathogenesis of respiratory syncytial virus infectionQ35848350
CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper functionQ36368291
Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia.Q36400958
Atypical pulmonary eosinophilia is mediated by a specific amino acid sequence of the attachment (G) protein of respiratory syncytial virusQ36401291
Treg control of antimicrobial T cell responsesQ36450013
Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance PQ36464353
Regulatory T cells in virus infectionsQ36563550
Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing the Th1/Th2 cytokine balance toward increased levels of Th2 cytokines and IgE, markers of allergy--a reviewQ36593301
Immunization of mice with vaccinia virus-M2 recombinant induces epitope-specific and cross-reactive Kd-restricted CD8+ cytotoxic T cellsQ36650105
Characterization of recombinant respiratory syncytial viruses with the region responsible for type 2 T-cell responses and pulmonary eosinophilia deleted from the attachment (G) protein.Q36684360
Antigenic relatedness between glycoproteins of human respiratory syncytial virus subgroups A and B: evaluation of the contributions of F and G glycoproteins to immunityQ36919232
Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cellsQ36937131
Lck mediates Th2 differentiation through effects on T-bet and GATA-3.Q36956614
Attenuation of live respiratory syncytial virus vaccines is associated with reductions in levels of nasal cytokinesQ36957257
Regulation of adaptive immunity by the fractalkine receptor during autoimmune inflammationQ37038789
T follicular helper (TFH) cells in normal and dysregulated immune responsesQ37049341
Mortality rates of human metapneumovirus and respiratory syncytial virus lower respiratory tract infections in hematopoietic cell transplantation recipientsQ37118406
Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparitiesQ37127882
A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunctionQ37157161
Characterization of respiratory syncytial virus M- and M2-specific CD4 T cells in a murine modelQ37192233
Identification of epitopes on respiratory syncytial virus proteins by competitive binding immunoassayQ37203117
A respiratory syncytial virus (RSV) anti-G protein F(ab')2 monoclonal antibody suppresses mucous production and breathing effort in RSV rA2-line19F-infected BALB/c miceQ37252613
Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in miceQ37252618
The host response and molecular pathogenesis associated with respiratory syncytial virus infectionQ37263779
HSP70/CD80 DNA vaccine inhibits airway remodeling by regulating the transcription factors T-bet and GATA-3 in a murine model of chronic asthmaQ37321867
Follicular helper T cells as cognate regulators of B cell immunityQ37510254
Strategic priorities for respiratory syncytial virus (RSV) vaccine developmentQ37572640
Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potentialQ37670253
Multiple functional domains and complexes of the two nonstructural proteins of human respiratory syncytial virus contribute to interferon suppression and cellular locationQ38749026
Respiratory syncytial virus fusion protein mediates inhibition of mitogen-induced T-cell proliferation by contactQ39682220
Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction.Q39963611
Neutralization of respiratory syncytial virus by individual and mixtures of F and G protein monoclonal antibodies.Q40130924
Microneutralization test for respiratory syncytial virus based on an enzyme immunoassayQ40222017
Safety and immunogenicity of respiratory syncytial virus purified fusion protein-2 vaccine in pregnant womenQ40555244
Calfection: a novel gene transfer method for suspension cells.Q40595125
An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccineQ40940832
Antigenic analysis of chimeric and truncated G proteins of respiratory syncytial virusQ41346333
Role of maternal antibody in pneumonia and bronchiolitis due to respiratory syncytial virusQ43542082
CX3C chemokine mimicry by respiratory syncytial virus G glycoproteinQ43690717
Respiratory syncytial virus deficient in soluble G protein induced an increased proinflammatory response in human lung epithelial cellsQ44237000
Comparison of the safety and immunogenicity of 2 respiratory syncytial virus (rsv) vaccines--nonadjuvanted vaccine or vaccine adjuvanted with alum--given concomitantly with influenza vaccine to high-risk elderly individualsQ44480572
Safety and immunogenicity of a novel recombinant subunit respiratory syncytial virus vaccine (BBG2Na) in healthy young adultsQ44982507
Role of neutralizing antibodies in adults with community-acquired pneumonia by respiratory syncytial virusQ45360497
Effect of respiratory syncytial virus infection on plasmacytoid dendritic cell regulation of allergic airway inflammationQ45363605
Therapeutic monoclonal antibody treatment targeting respiratory syncytial virus (RSV) G protein mediates viral clearance and reduces the pathogenesis of RSV infection in BALB/c miceQ45383435
Enhanced delivery and expression of a nanoencapsulated DNA vaccine vector for respiratory syncytial virus.Q45385542
Respiratory syncytial virus neutralizing antibodies in cord blood, respiratory syncytial virus hospitalization, and recurrent wheezeQ45387793
Human CD8(+) T cell responses against five newly identified respiratory syncytial virus-derived epitopesQ45610521
Lymphocyte apoptosis in acute respiratory syncytial virus bronchiolitis.Q45627167
Age related differences in humoral immune response to respiratory syncytial virus infection in adultsQ45644291
Immunogenicity of a new purified fusion protein vaccine to respiratory syncytial virus: a multi-center trial in children with cystic fibrosisQ45723625
Respiratory syncytial virus decreases the capacity of myeloid dendritic cells to induce interferon-gamma in naïve T cellsQ45723895
Immunoregulatory role of secreted glycoprotein G from respiratory syncytial virusQ45737617
Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody levelQ45792098
Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric populationQ45823296
Respiratory virus immunization. I. A field trial of two inactivated respiratory virus vaccines; an aqueous trivalent parainfluenza virus vaccine and an alum-precipitated respiratory syncytial virus vaccineQ45823297
Immunity to and frequency of reinfection with respiratory syncytial virusQ45853042
Infectious respiratory syncytial virus (RSV) effectively inhibits the proliferative T cell response to inactivated RSV in vitroQ45873441
Respiratory-syncytial-virus infections, reinfections and immunity. A prospective, longitudinal study in young childrenQ45888997
Diversity among memory B cells: origin, consequences, and utility.Q46918689
P4510describes a project that usesImageJQ1659584
P433issue18
P407language of work or nameEnglishQ1860
P304page(s)10569-10583
P577publication date2014-07-02
P1433published inJournal of VirologyQ1251128
P1476titleProphylaxis with a respiratory syncytial virus (RSV) anti-G protein monoclonal antibody shifts the adaptive immune response to RSV rA2-line19F infection from Th2 to Th1 in BALB/c mice
P478volume88

Reverse relations

cites work (P2860)
Q40823850A Recombinant G Protein Plus Cyclosporine A-Based Respiratory Syncytial Virus Vaccine Elicits Humoral and Regulatory T Cell Responses against Infection without Vaccine-Enhanced Disease
Q38983251A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza
Q35893983An anti-G protein monoclonal antibody treats RSV disease more effectively than an anti-F monoclonal antibody in BALB/c mice
Q92021897Antibody development for preventing the human respiratory syncytial virus pathology
Q38598484Antiviral Monoclonal Antibodies: Can They Be More Than Simple Neutralizing Agents?
Q92556931Biology of Infection and Disease Pathogenesis to Guide RSV Vaccine Development
Q90521301Comparisons of Antibody Populations in Different Pre-Fusion F VLP-Immunized Cotton Rat Dams and Their Offspring
Q27468870Converting monoclonal antibody-based immunotherapies from passive to active: bringing immune complexes into play
Q36256989Cotton rat immune responses to virus-like particles containing the pre-fusion form of respiratory syncytial virus fusion protein.
Q91798893Epitope-specific airway-resident CD4+ T cell dynamics during experimental human RSV infection
Q52605312Expression and clinical significance of PD‑1 in hepatocellular carcinoma tissues detected by a novel mouse anti-human PD‑1 monoclonal antibody.
Q64060972Fc-Mediated Antibody Effector Functions During Respiratory Syncytial Virus Infection and Disease
Q38635643Human Genetic Determinants of Viral Diseases
Q58566613Human Metapneumovirus: Mechanisms and Molecular Targets Used by the Virus to Avoid the Immune System
Q90458905In vitro model for the assessment of human immune responses to subunit RSV vaccines
Q36409517Layer-By-Layer Nanoparticle Vaccines Carrying the G Protein CX3C Motif Protect against RSV Infection and Disease
Q39154023Modulation of the host immune response by respiratory syncytial virus proteins
Q36246429Monoclonal Antibody against G Glycoprotein Increases Respiratory Syncytial Virus Clearance In Vivo and Prevents Vaccine-Enhanced Diseases
Q40301155Mutating the CX3C Motif in the G Protein Should Make a Live Respiratory Syncytial Virus Vaccine Safer and More Effective
Q92083068Mutation of Respiratory Syncytial Virus G Protein's CX3C Motif Attenuates Infection in Cotton Rats and Primary Human Airway Epithelial Cells
Q89884849Natural killer cell activation by respiratory syncytial virus-specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc-glycosylation
Q116166317Structural Characterization of Ectodomain G Protein of Respiratory Syncytial Virus and Its Interaction with Heparan Sulfate: Multi-Spectroscopic and In Silico Studies Elucidating Host-Pathogen Interactions
Q36764982Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway.
Q41813514Targeting Host Cell Surface Nucleolin for RSV Therapy: Challenges and Opportunities

Search more.