Sanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of action

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Sanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of action is …
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scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.166.12.7165
P698PubMed publication ID11390463
P5875ResearchGate publication ID11949785

P2093author name stringFuchs S
Quesniaux VF
Brinkmann V
Billich A
Schuler W
Strittmatter U
Zenke G
Zurini M
Enz A
Fehr T
Sanglier JJ
P2860cites workSanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. II. Structure elucidation, stereochemistry and physico-chemical propertiesQ78238726
Sanglifehrins A, B, C and D, Novel Cyclophilin-binding Compounds Isolated from Streptomyces sp. A92-308110. I. Taxonomy, Fermentation, Isolation and Biological Activity.Q105024226
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)7165-7171
P577publication date2001-06-01
P1433published inJournal of ImmunologyQ3521441
P1476titleSanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of action
P478volume166

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cites work (P2860)
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Q59330226Cyclophilin A as a target in the treatment of cytomegalovirus infections
Q44526080Cyclophilin A interacts with HIV-1 Vpr and is required for its functional expression
Q40054442Cyclophilin A is required for CXCR4-mediated nuclear export of heterogeneous nuclear ribonucleoprotein A2, activation and nuclear translocation of ERK1/2, and chemotactic cell migration
Q54587476Cyclophilin A is required for M-CSF-dependent macrophage proliferation.
Q90704771Cyclophilin Inhibitor NV556 Reduces Fibrosis and Hepatocellular Carcinoma Development in Mice With Non-Alcoholic Steatohepatitis
Q38615621Cyclophilin inhibitors as a novel HCV therapy
Q44673393Cyclophilin sensitivity to sanglifehrin A can be correlated to the same specific tryptophan residue as cyclosporin A.
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Q35620073Dendritic cells: emerging pharmacological targets of immunosuppressive drugs
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Q40359728Immunosuppressive activity of the immunophilin-binding drug Sanglifehrin A in human whole blood: potent inhibition of interleukin-6 produced by lymphocytes and monocytes
Q43738139Inhibition of cell cycle progression by the novel cyclophilin ligand sanglifehrin A is mediated through the NFkappa B-dependent activation of p53.
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