Common requirements for melanocortin-4 receptor selectivity of structurally unrelated melanocortin agonist and endogenous antagonist, Agouti protein

scientific article

Common requirements for melanocortin-4 receptor selectivity of structurally unrelated melanocortin agonist and endogenous antagonist, Agouti protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M007261200
P698PubMed publication ID11024027

P2093author name stringGispen WH
Barsh GS
Burbach JP
Adan RA
Oosterom J
Nijenhuis WA
Garner KM
den Dekker WK
P2860cites workAntagonism of central melanocortin receptors in vitro and in vivo by agouti-related proteinQ24314579
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptorQ28239346
A frameshift mutation in human MC4R is associated with a dominant form of obesityQ28285286
Characterization of Agouti-related protein binding to melanocortin receptorsQ28294211
Targeted disruption of the melanocortin-4 receptor results in obesity in miceQ28302831
Melanocortin receptor binding determinants in the agouti proteinQ28509746
Medicinal strategies in the treatment of obesityQ33892355
Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant miceQ34423145
Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic systemQ36557845
The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated miceQ36759685
Mutations in the carboxyl terminus of the agouti protein decrease agouti inhibition of ligand binding to the melanocortin receptorsQ41126826
Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice. The yellow mouse syndromeQ41471298
Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutationQ46131478
Different developmental patterns of melanocortin MC3 and MC4 receptor mRNA: predominance of Mc4 in fetal rat nervous systemQ48038995
Molecular characterization of the mouse agouti locus.Q48143334
Conformation of the core sequence in melanocortin peptides directs selectivity for the melanocortin MC3 and MC4 receptorsQ48192978
Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat.Q48269651
Application of the flame photometric sulfur detector to the gas-chromatographic analysis of trimethylsilylated methylthiohydantoins of amino acidsQ54192530
Effects of Recombinant Agouti-Signaling Protein on Melanocortin ActionQ55869263
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)931-936
P577publication date2001-01-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleCommon requirements for melanocortin-4 receptor selectivity of structurally unrelated melanocortin agonist and endogenous antagonist, Agouti protein
P478volume276

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cites work (P2860)
Q24530304Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides
Q30909790Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides.
Q40769120Functional properties of an agouti signaling protein variant and characteristics of its cognate radioligand
Q48278586Gene expression in hypothalamus, liver, and adipose tissues and food intake response to melanocortin-4 receptor agonist in pigs expressing melanocortin-4 receptor mutations
Q90501515Insights into the Allosteric Mechanism of Setmelanotide (RM-493) as a Potent and First-in-Class Melanocortin-4 Receptor (MC4R) Agonist To Treat Rare Genetic Disorders of Obesity through an in Silico Approach
Q44523641Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure
Q48218242Melanocortin-4 receptor regulates hippocampal synaptic plasticity through a protein kinase A-dependent mechanism.
Q49841474Molecular characterization of feline melanocortin 4 receptor and melanocortin 2 receptor accessory protein 2.
Q30875407Molecular signatures reveal circadian clocks may orchestrate the homeorhetic response to lactation
Q38355676Poor Cell Surface Expression of Human Melanocortin-4 Receptor Mutations Associated with Obesity
Q37826251Structure, function and regulation of the melanocortin receptors
Q38192648Synaptic changes induced by melanocortin signalling.
Q91968695The melanocortin pathway and control of appetite-progress and therapeutic implications
Q40604442The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs
Q36003378The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.

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