| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1045929899 |
| P356 | DOI | 10.1038/371799A0 |
| P3181 | OpenCitations bibliographic resource ID | 1173734 |
| P698 | PubMed publication ID | 7935841 |
| P50 | author | Richard P Woychik | Q61783658 |
| P2093 | author name string | I R Patel | |
| D Lu | |||
| W Chen | |||
| D Willard | |||
| M Luther | |||
| W O Wilkison | |||
| T Kost | |||
| L Overton | |||
| S Kadwell | |||
| P2860 | cites work | The cloning of a family of genes that encode the melanocortin receptors | Q24337156 |
| Molecular cloning of a novel human melanocortin receptor | Q28263897 | ||
| Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing | Q28273821 | ||
| Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. | Q34362234 | ||
| Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system | Q36557845 | ||
| Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene | Q36748960 | ||
| 2 Cellular responsiveness to hormones and neutrotransmitters: Conversion of 3HAdenine to 3HcAMP in cell monolayers, cell suspensions, and tissue slices | Q41703901 | ||
| Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. | Q43581712 | ||
| Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation | Q46131478 | ||
| Molecular characterization of the mouse agouti locus. | Q48143334 | ||
| Colour-coded switches | Q57338467 | ||
| Mouse coat colour reconsidered | Q60092627 | ||
| Site of gene action in the development of hair pigment in recessive yellow () mice | Q66899046 | ||
| 1 Assay of adenylyl cyclase catalytic activity | Q67916457 | ||
| Hereditary Obesity and Efficient Food Utilization in Mice | Q81072411 | ||
| P433 | issue | 6500 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 799-802 | |
| P577 | publication date | 1994-10-01 | |
| P1433 | published in | Nature | Q180445 |
| P1476 | title | Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor | |
| P478 | volume | 371 |
| Q26768703 | 60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH |
| Q36237694 | A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands |
| Q28505368 | A biochemical function for attractin in agouti-induced pigmentation and obesity |
| Q28287886 | A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse |
| Q33622891 | A composite six bp in-frame deletion in the melanocortin 1 receptor (MC1R) gene is associated with the Japanese brindling coat colour in rabbits (Oryctolagus cuniculus) |
| Q28117916 | A frameshift mutation in MC4R associated with dominantly inherited human obesity |
| Q37533047 | A genome-wide scan study identifies a single nucleotide substitution in ASIP associated with white versus non-white coat-colour variation in sheep (Ovis aries) |
| Q35431515 | A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors |
| Q28301323 | A missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated with the chestnut coat color in horses |
| Q48053416 | A non-epistatic interaction of agouti and extension in the fox, Vulpes vulpes. |
| Q41731733 | A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. |
| Q37361476 | A polymorphism in the agouti signaling protein gene is associated with human pigmentation |
| Q54601299 | A polymorphism in the agouti signalling protein (ASIP) is associated with decreased levels of mRNA. |
| Q42692290 | A possible involvement of melanocortin 3 receptor in the regulation of adrenal gland function in the chicken |
| Q38360259 | A role for melanin-concentrating hormone in the central regulation of feeding behaviour |
| Q24535020 | A role for the melanocortin 4 receptor in sexual function |
| Q73544868 | ACTH- and alpha-MSH-induced grooming, stretching, yawning and penile erection in male rats: site of action in the brain and role of melanocortin receptors |
| Q42377853 | ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase |
| Q81236755 | Abnormalities of the somatotrophic axis in the obese agouti mouse |
| Q37175951 | Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin |
| Q38499991 | Adaptive potential of genomic structural variation in human and mammalian evolution. |
| Q41193513 | Adipogenesis and obesity: rounding out the big picture |
| Q36971495 | Advances in murine models of diabetic nephropathy |
| Q33665882 | Advances in the molecular genetics of obesity |
| Q43257118 | Age dependence of glucose tolerance in adult KK-Ay mice, a model of non-insulin dependent diabetes mellitus |
| Q34788441 | Agnostic about in vivo inverse agonism of agouti-related peptide |
| Q55404044 | Agouti Signaling Protein and Its Receptors as Potential Molecular Markers for Intramuscular and Body Fat Deposition in Cattle. |
| Q34258381 | Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice |
| Q51553416 | Agouti related protein in the rat adrenal cortex: implications for novel autocrine mechanisms modulating the actions of pro-opiomelanocortin peptides. |
| Q34243666 | Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization. |
| Q40678792 | Agouti signal protein regulation in human melanoma cells |
| Q40786615 | Agouti signaling protein and other factors modulating differentiation and proliferation of immortal melanoblasts |
| Q48314163 | Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice |
| Q40820073 | Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor |
| Q34523557 | Agouti: from mouse to man, from skin to fat. |
| Q48826679 | Agrp, a novel gene implicated in the control of feeding |
| Q41418496 | Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9. |
| Q36310137 | Amelanism in the corn snake is associated with the insertion of an LTR-retrotransposon in the OCA2 gene |
| Q35556293 | An agouti mutation lacking the basic domain induces yellow pigmentation but not obesity in transgenic mice |
| Q34482525 | Analysis of the sheep genome |
| Q24314579 | Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein |
| Q42512363 | Antagonist and agonist activities of the mouse agouti protein fragment (91-131) at the melanocortin-1 receptor |
| Q73293527 | Antiobesity and antidiabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance |
| Q34205173 | Approach to assessing determinants of glucose homeostasis in the conscious mouse |
| Q89166481 | Arg-Phe-Phe d-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Results in Unanticipated Melanocortin-1 Receptor Agonist Profiles |
| Q50763185 | Association of an Agouti allele with fawn or sable coat color in domestic dogs. |
| Q37112113 | Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study |
| Q34384734 | Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians |
| Q83185123 | Aza-scanning of the potent melanocortin receptor agonist Ac-His-D-Phe-Arg-Trp-NH |
| Q46360823 | BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal-Ventral Pigment Asymmetry in Fish |
| Q34667950 | BDNF regulates eating behavior and locomotor activity in mice |
| Q39785333 | Behind melanocortin antagonist overexpression in the zebrafish brain: A behavioral and transcriptomic approach |
| Q39211934 | Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016. |
| Q34330717 | Biological influences on obesity |
| Q37350057 | Biological insights through genomics: mouse to man. |
| Q36996595 | Biology of epidermal and hair pigmentation in cattle: a mini-review |
| Q34497095 | Biology of obesity: lessons from animal models of obesity |
| Q37223442 | Blockade of melanocortin transmission inhibits cocaine reward |
| Q74481068 | Body and organ mass in agouti and non-agouti deer mice (Peromyscus maniculatus) |
| Q74261611 | Body mass index-related human adipocyte agouti expression is sex-specific but not depot-specific |
| Q35913048 | Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway |
| Q41659816 | Brain melanocortin receptors: from cloning to function |
| Q28512879 | Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor |
| Q47276753 | Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight. |
| Q47978333 | CNS Targets of Adipokines |
| Q30838486 | CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene. |
| Q28752475 | CXCL14 deficiency in mice attenuates obesity and inhibits feeding behavior in a novel environment |
| Q41959673 | Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism |
| Q48466561 | Central alpha-melanocyte-stimulating hormone acts at melanocortin-4 receptor to activate sympathetic nervous system in conscious rabbits |
| Q48311540 | Central injection in rats of alpha-melanocyte-stimulating hormone analog: effects on food intake and brain Fos. |
| Q40670092 | Characterization of aliphatic, cyclic, and aromatic N-terminally "capped" His-D-Phe-Arg-Trp-NH2 tetrapeptides at the melanocortin receptors |
| Q36487455 | Characterization of genes modulated during pheomelanogenesis using differential display |
| Q28373060 | Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat |
| Q34364247 | Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd Dogs |
| Q48066748 | Characterization of the rabbit agouti signaling protein (ASIP) gene: transcripts and phylogenetic analyses and identification of the causative mutation of the nonagouti black coat colour |
| Q51326567 | Characterization, tissue distribution and regulation by fasting of the agouti family of peptides in the sea bass (Dicentrarchus labrax). |
| Q30938720 | Characterizing neutral genomic diversity and selection signatures in indigenous populations of Moroccan goats (Capra hircus) using WGS data |
| Q62661091 | Chemical characterization of pheomelanogenesis starting from dihydroxyphenylalanine or tyrosine and cysteine |
| Q72031951 | Chewing the fat |
| Q34036610 | Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus |
| Q35903196 | Circumventing leptin resistance for weight control |
| Q52623380 | Coat colours in the Massese sheep breed are associated with mutations in the agouti signalling protein (ASIP) and melanocortin 1 receptor (MC1R) genes. |
| Q35966098 | Combined effects of insulin treatment and adipose tissue-specific agouti expression on the development of obesity |
| Q35120997 | Common endocrine control of body weight, reproduction, and bone mass |
| Q40850484 | Common requirements for melanocortin-4 receptor selectivity of structurally unrelated melanocortin agonist and endogenous antagonist, Agouti protein |
| Q41165076 | Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors. |
| Q50519706 | Comparative analysis of melanins and melanosomes produced by various coat color mutants. |
| Q33926210 | Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor |
| Q22009530 | Contribution of melanocortin receptor exoloops to Agouti-related protein binding |
| Q35855077 | Control of penile erection by the melanocortinergic system: experimental evidences and therapeutic perspectives |
| Q47966620 | Cutaneous immunomodulation and coordination of skin stress responses by alpha-melanocyte-stimulating hormone |
| Q35551884 | Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors |
| Q48797543 | DNA methylation regulates hypothalamic gene expression linking parental diet during pregnancy to the offspring's risk of obesity in Psammomys obesus |
| Q89030305 | Deficient ganglioside synthesis restores responsiveness to leptin and melanocortin signaling in obese KKAy mice |
| Q55260585 | Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit. |
| Q48038995 | Different developmental patterns of melanocortin MC3 and MC4 receptor mRNA: predominance of Mc4 in fetal rat nervous system |
| Q34061106 | Differential effects of insulin on sympathetic nerve activity in agouti obese mice |
| Q48707324 | Differential influence of a selective melanocortin MC4 receptor antagonist (HS014) on melanocortin-induced behavioral effects in rats |
| Q38316328 | Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction |
| Q41255017 | Differential spontaneous transformation in vitro of newly established mouse fibroblast lines carrying or lacking the viable yellow mutation (Avy) of the mouse agouti locus |
| Q88760563 | Discovery of Melanocortin Ligands via a Double Simultaneous Substitution Strategy Based on the Ac-His-dPhe-Arg-Trp-NH2 Template |
| Q36357786 | Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2. |
| Q41666493 | Down-regulation of melanocortin receptor signaling mediated by the amino terminus of Agouti protein in Xenopus melanophores |
| Q34435148 | Drug target discovery by pharmacogenetics: mutations in the melanocortin system and eating disorders |
| Q34135268 | Drug treatment of obesity: from past failures to future successes? |
| Q34257905 | Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur |
| Q47142040 | Effect of short term diet restriction on gene expression in the bovine hypothalamus using next generation RNA sequencing technology |
| Q35807892 | Effect of the Y chromosome on testis weight in mice |
| Q50140678 | Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues |
| Q50520078 | Elaborate color patterns of individual chicken feathers may be formed by the agouti signaling protein. |
| Q38333665 | Evidence of altered hypothalamic pro-opiomelanocortin/ neuropeptide Y mRNA expression in tubby mice |
| Q46925691 | FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens |
| Q83038880 | Feather follicles express two classes of pro-opiomelanocortin (POMC) mRNA using alternative promoters in chickens |
| Q74136043 | Fecal corticosteroids in agouti and non-agouti deer mice (Peromyscus maniculatus) |
| Q48329107 | Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands |
| Q47818605 | From genesis to gene sequencing: historical progress in the understanding of skin color |
| Q40769120 | Functional properties of an agouti signaling protein variant and characteristics of its cognate radioligand |
| Q37760961 | Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes |
| Q35186144 | Further characterization of diabetes mellitus and body weight loss in males of the congenic mouse strain DDD.Cg-A(y.). |
| Q35107263 | Gene-diet interactions in childhood obesity |
| Q33680466 | Genes involved in animal models of obesity and anorexia |
| Q33673158 | Genetic and epigenetic control of the proliferation and differentiation of mouse epidermal melanocytes in culture |
| Q47229779 | Genetic architecture of adiposity and organ weight using combined generation QTL analysis |
| Q33599821 | Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions |
| Q36891646 | Genetic background (DDD/Sgn versus C57BL/6J) strongly influences postnatal growth of male mice carrying the A(y) allele at the agouti locus: identification of quantitative trait loci associated with diabetes and body weight loss |
| Q33294507 | Genetic effects on coat colour in cattle: dilution of eumelanin and phaeomelanin pigments in an F2-Backcross Charolais x Holstein population |
| Q37319313 | Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17. |
| Q33970516 | Genetic studies of the mouse mutations mahogany and mahoganoid |
| Q41284438 | Genetics of obesity in humans and animal models |
| Q34388612 | Genome scan for human obesity and linkage to markers in 20q13. |
| Q84020832 | Getting biological about the genetics of diabetes |
| Q36993604 | Ghrelin and feedback systems |
| Q42652991 | Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei |
| Q41969194 | Ghrelin is an orexigenic peptide and elicits anxiety-like behaviors following administration into discrete regions of the hypothalamus |
| Q34989945 | Global patterns of diversity and selection in human tyrosinase gene |
| Q45272363 | HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice |
| Q35126774 | Haploinsufficiency of the melanocortin-4 receptor: part of a thrifty genotype? |
| Q24548049 | High polymorphism at the human melanocortin 1 receptor locus |
| Q39009925 | How mice are indispensable for understanding obesity and diabetes genetics |
| Q34143823 | How obesity develops: insights from the new biology |
| Q88172760 | Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors |
| Q24336776 | Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity |
| Q34492938 | Hypothalamic and vagal neuropeptide circuitries regulating food intake |
| Q38335615 | Identification of SOCS-3 as a potential mediator of central leptin resistance |
| Q34345483 | Identification of distant Agouti-like sequences and re-evaluation of the evolutionary history of the Agouti-related peptide (AgRP). |
| Q37042467 | Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice |
| Q41300224 | Impact of the Polymorphism Near MC4R (rs17782313) on Obesity- and Metabolic-Related Traits in Women Participating in an Aerobic Training Program. |
| Q59096290 | In search of a satiety factor |
| Q34979349 | In silico mutagenesis: a case study of the melanocortin 4 receptor |
| Q74268345 | Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass |
| Q48492691 | Increased inhibition by agouti-related peptide of ventromedial hypothalamic neurons in rats overweight due to early postnatal overfeeding |
| Q40493445 | Induction of brain-region-specific forms of obesity by agouti. |
| Q34303458 | Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. |
| Q26852866 | Insights into obesity and diabetes at the intersection of mouse and human genetics |
| Q33939065 | Integrated control of appetite and fat metabolism by the leptin-proopiomelanocortin pathway |
| Q24607871 | Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo |
| Q43788100 | Interaction of melanin-concentrating hormone (MCH), neuropeptide E-I (NEI), neuropeptide G-E (NGE), and alpha-MSH with melanocortin and MCH receptors on mouse B16 melanoma cells |
| Q38896217 | Interactive Effects of Neurochemicals on Ingestive Behavior |
| Q44343227 | Interrelationships between μ opioid and melanocortin receptors in mediating food intake in rats |
| Q33898777 | Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery |
| Q35161587 | Inverse agonism gains weight |
| Q44512668 | Inverse agonist activity of agouti and agouti-related protein. |
| Q37822862 | Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine |
| Q47792289 | Involvement of microphthalmia in the inhibition of melanocyte lineage differentiation and of melanogenesis by agouti signal protein. |
| Q33697951 | Involvement of the melanocortin-1 receptor in acute pain and pain of inflammatory but not neuropathic origin |
| Q48025415 | Isolation, cloning, and sequencing of porcine agouti exon 2 (PorAex2). |
| Q48549214 | Jacques Benoit Lecture. Information processing in the hypothalamus: peptides and analogue computation |
| Q34390769 | Knockout models resulting in the development of obesity |
| Q88159127 | Left-right pigmentation pattern of Japanese flounder corresponds to expression levels of melanocortin receptors (MC1R and MC5R), but not to agouti signaling protein 1 (ASIP1) expression |
| Q42263142 | Lentivirus-mediated α-melanocyte-stimulating hormone overexpression in the hypothalamus decreases diet induced obesity in mice. |
| Q38330261 | Leptin and its receptors: regulators of whole-body energy homeostasis |
| Q35025276 | Leptin and melanocortin signaling in the hypothalamus |
| Q29617231 | Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects |
| Q34157988 | Leptin regulates bone formation via the sympathetic nervous system |
| Q73194988 | Leptin-induced increase in sympathetic nervous and cardiovascular tone is mediated by proopiomelanocortin (POMC) products |
| Q34197101 | Leptin: of mice and men? |
| Q41284427 | Lessons from animal models of obesity |
| Q24654507 | Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Québec Family Study |
| Q24799830 | Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes |
| Q58051415 | Local Mineralocorticoid Receptor Activation and the Role of Rac1 in Obesity-Related Diabetic Kidney Disease |
| Q41747645 | Long-term orexigenic effects of AgRP-(83---132) involve mechanisms other than melanocortin receptor blockade |
| Q38210121 | MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation |
| Q52686348 | MC4R Agonists: Structural Overview on Antiobesity Therapeutics. |
| Q90306391 | MITF and UV responses in skin: From pigmentation to addiction |
| Q34175377 | Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein |
| Q36531492 | Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti |
| Q24314383 | Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas |
| Q38742674 | Making sense of the sensory regulation of hunger neurons |
| Q34256965 | Mechanisms for the pleiotropic effects of the agouti gene |
| Q34144307 | Melanin-concentrating hormone and its receptor are expressed and functional in human skin. |
| Q26745953 | Melanocortin 1 Receptor: Structure, Function, and Regulation |
| Q35943108 | Melanocortin 1 receptor variants, pigmentation, and skin cancer susceptibility. |
| Q42603999 | Melanocortin 1-receptor (MC1R) mutations are associated with plumage colour in chicken |
| Q33668965 | Melanocortin 4 receptor becomes an ACTH receptor by coexpression of melanocortin receptor accessory protein 2. |
| Q60912747 | Melanocortin Receptor Accessory Protein 2-Induced Adrenocorticotropic Hormone Response of Human Melanocortin 4 Receptor |
| Q48354001 | Melanocortin and MCH precursor-derived NEI effects on striatum-midbrain co-cultures |
| Q33539994 | Melanocortin and leptin signaling systems: central regulation of catabolic energy balance |
| Q35103464 | Melanocortin control of energy balance: evidence from rodent models |
| Q61695193 | Melanocortin mediated inhibition of feeding behavior in rats |
| Q34605779 | Melanocortin receptor 1 (MC1R) mutations and coat color in pigs |
| Q28580846 | Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat |
| Q27013622 | Melanocortin receptor accessory proteins in adrenal disease and obesity |
| Q31845692 | Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells |
| Q47279370 | Melanocortin receptors and antagonists regulate pigmentation and body weight |
| Q47841173 | Melanocortin receptors weigh in. |
| Q41334630 | Melanocortin receptors: identification and characterization by melanotropic peptide agonists and antagonists |
| Q56908897 | Melanocortin receptors: new opportunities in drug discovery |
| Q33709299 | Melanocortin receptors: perspectives for novel drugs |
| Q42738533 | Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-3 receptor agonist versus antagonist activity |
| Q34562487 | Melanocortin-1 receptor structure and functional regulation. |
| Q33782186 | Melanocortin-3 receptors and metabolic homeostasis |
| Q33935621 | Melanocortins and feeding behavior. |
| Q34060958 | Melanocortins and the brain: from effects via receptors to drug targets |
| Q28260249 | Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5 |
| Q34321895 | Metabolism and the circadian clock converge |
| Q39855336 | Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity. |
| Q28593260 | Mex3c mutation reduces adiposity and increases energy expenditure |
| Q34600995 | Milnacipran, a serotonin and norepinephrine reuptake inhibitor, induces appetite-suppressing effects without inducing hypothalamic stress responses in mice |
| Q33496603 | Missense and nonsense mutations in melanocortin 1 receptor (MC1R) gene of different goat breeds: association with red and black coat colour phenotypes but with unexpected evidences |
| Q33886866 | Modulation of murine melanocyte function invitro by agouti signal protein |
| Q30585567 | Modulation of social behavior by the agouti pigmentation gene |
| Q41121039 | Modulation of tumor cell gene expression and phenotype by the organ-specific metastatic environment |
| Q94164476 | Molecular and pharmacological characterisation of the MSH-R alleles in Swiss cattle breeds |
| Q34614453 | Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus |
| Q33966677 | Molecular basis of the pleiotropic phenotype of mice carrying the hypervariable yellow (Ahvy) mutation at the agouti locus |
| Q36451988 | Molecular biology and physiology of the melanocortin system in fish: a review. |
| Q47949633 | Molecular cloning and characterization of the chicken pro-opiomelanocortin (POMC) gene |
| Q40293299 | Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphism |
| Q35574544 | Monitoring of stored and available fuel by the CNS: implications for obesity |
| Q52127812 | Mouse melanocortin-4 receptor gene 5'-flanking region imparts cell specific expression in vitro. |
| Q33849244 | Mouse models of the metabolic syndrome |
| Q37726409 | Mutations in melanocortin-4 receptor and human obesity. |
| Q57308923 | Nature, Origin, and Variation of Human Pigmentation |
| Q24540108 | Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice |
| Q37284868 | Neural melanocortin receptors in obesity and related metabolic disorders |
| Q35165383 | Neural regulation of blood pressure by leptin and the related peptides |
| Q43993573 | Neurochemical phenotype of hypothalamic neurons showing Fos expression 23 h after intracranial AgRP. |
| Q44796631 | Neurohumoral regulation of body weight gain |
| Q38354658 | Neuronal Histamine Regulates Food Intake, Adiposity, and Uncoupling Protein Expression in Agouti Yellow (Ay/a) Obese Mice |
| Q91601937 | Neuropeptides at the crossroad of fear and hunger: a special focus on neuropeptide Y |
| Q37200647 | New Zealand Ginger mouse: novel model that associates the tyrp1b pigmentation gene locus with regulation of lean body mass |
| Q37366372 | New ligands for melanocortin receptors |
| Q24315086 | Novel binding motif of ACTH analogues at the melanocortin receptors |
| Q44485757 | Novel tetrahydropyran-based peptidomimetics from a bioisosteric transformation of a tripeptide. Evidence of their activity at melanocortin receptors |
| Q37655958 | Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity |
| Q28263965 | Obesity and the hypothalamus: novel peptides for new pathways |
| Q30080025 | Obesity and the regulation of energy balance |
| Q41611184 | Obesity genes and insulin resistance syndrome |
| Q40851943 | Obesity genes: molecular genetic approaches to drug target identification |
| Q78199477 | Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin |
| Q41461630 | Obesity, diabetes and functions for proopiomelanocortin-derived peptides |
| Q30243992 | Obesity: Current and potential pharmacotherapeutics and targets |
| Q91497015 | Obesity: a neuroimmunometabolic perspective |
| Q34014388 | Obesity: an epidemic in need of therapeutics |
| Q37190525 | Oleic acid directly regulates POMC neuron excitability in the hypothalamus |
| Q31920302 | Opioid receptor involvement in the effect of AgRP- (83-132) on food intake and food selection. |
| Q33419364 | Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice |
| Q44831631 | Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus |
| Q55067245 | Overexpression of Agrt leads to obesity in transgenic mice. |
| Q43701492 | Overexpression of agouti protein and stress responsiveness in mice |
| Q35192316 | PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage. |
| Q40437354 | Pathophysiological role of leptin in obesity-related hypertension. |
| Q91830139 | Pharmacological modulation of melanocortin-4 receptor by melanocortin receptor accessory protein 2 in Nile tilapia |
| Q34146257 | Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene |
| Q37210932 | Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax) |
| Q34872754 | Pigment pattern formation in zebrafish: a model for developmental genetics and the evolution of form |
| Q34377564 | Pineal-specific agouti protein regulates teleost background adaptation |
| Q91837584 | Polymorphism in MC1R, TYR and ASIP genes in different colored feather chickens |
| Q38355676 | Poor Cell Surface Expression of Human Melanocortin-4 Receptor Mutations Associated with Obesity |
| Q34305155 | Population Differences in the Frequency of the Agouti Signaling Protein g.8818A > G Polymorphism |
| Q48020141 | Porcine Agouti gene map position SSC 17q21. |
| Q80098666 | Pre-obese and obese agouti mice are sensitive to the anorectic effects of peptide YY(3-36) but resistant to ghrelin |
| Q57384549 | Prevalence and phenotypic characterization of MC4R variants in a large pediatric cohort |
| Q38420594 | Pro-Opiomelanocortin (POMC) Neurones, POMC-Derived Peptides, Melanocortin Receptors and Obesity: How Understanding of this System has Changed Over the Last Decade |
| Q116206004 | Pro-opiomelanocortin gene and melanin-based colour polymorphism in a reptile |
| Q35617479 | Progressive obesity alters ovarian folliculogenesis with impacts on pro-inflammatory and steroidogenic signaling in female mice. |
| Q47566629 | Progressive obesity alters ovarian insulin, phosphatidylinositol-3 kinase, and chemical metabolism signaling pathways and potentiates ovotoxicity induced by phosphoramide mustard in mice |
| Q48602552 | Progressive obesity alters the steroidogenic response to ovulatory stimulation and increases the abundance of mRNAs stored in the ovulated oocyte |
| Q37306848 | Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study |
| Q74666023 | Quantitative trait loci that regulate plasma lipid concentration in hereditary obese KK and KK-Ay mice |
| Q34468332 | Quantitative trait locus mapping of genes associated with vacuolation in the adrenal X-zone of the DDD/Sgn inbred mouse |
| Q34432036 | Quantitative trait locus mapping of genes that control body length and plasma insulin-like growth factor 1 level in mice |
| Q35597667 | Recent developments in our understanding of melanocortin system in the regulation of food intake |
| Q24306067 | Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2 |
| Q38360631 | Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. |
| Q42835380 | Regulation of leptin by agouti |
| Q44590688 | Regulation of melanocortin 1 receptor expression at the mRNA and protein levels by its natural agonist and antagonist |
| Q51580359 | Regulation of obese gene expression in KK mice and congenic lethal yellow obese KKAy mice. |
| Q33995891 | Regulation of pigmentation in zebrafish melanophores |
| Q60907374 | Regulation of substrate utilization and adiposity by Agrp neurons |
| Q44149396 | Relationships between obesity and metabolic hormones in the "cobalt" variant of rainbow trout. |
| Q37101314 | Relevance of animal models to human eating disorders and obesity. |
| Q54107503 | Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. |
| Q48228971 | Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms. |
| Q38299000 | Role of adipocytokines in hepatic fibrogenesis |
| Q28300979 | Role of melanocortinergic neurons in feeding and the agouti obesity syndrome |
| Q34060964 | Role of melanocortins in the central control of feeding |
| Q74201160 | Role of the melanocortin-4 receptor in metabolic rate and food intake in mice |
| Q47772359 | Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system |
| Q44911292 | Seeing the gene therapy: application of gene gun technique to transfect and decolour pigmented rat skin with human agouti signalling protein cDNA. |
| Q35134323 | Selection for complex traits leaves little or no classic signatures of selection. |
| Q92006417 | Selection signatures in goats reveal copy number variants underlying breed-defining coat color phenotypes |
| Q28141043 | Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors |
| Q24323379 | Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans |
| Q37750938 | Shades of meaning: the pigment-type switching system as a tool for discovery |
| Q35015746 | Sixteen years and counting: an update on leptin in energy balance |
| Q34583185 | Solid-phase peptide head-to-side chain cyclodimerization: Discovery of C2-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors |
| Q27620557 | Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B |
| Q24303874 | Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance |
| Q34616432 | Stepping up melanocytes to the challenge of UV exposure |
| Q36824447 | Strategies for assessment of botanical action on metabolic syndrome in the mouse and evidence for a genotype-specific effect of Russian tarragon in the regulation of insulin sensitivity |
| Q40895661 | Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions |
| Q94050477 | Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake |
| Q47945714 | Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacolog |
| Q24653947 | Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor |
| Q86186199 | Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse |
| Q40671787 | Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 at the mouse melanocortin receptors. Part 3: modifications at the Arg position |
| Q34700718 | Structure-activity studies of new melanocortin peptides containing an aromatic amino acid at the N-terminal position |
| Q78125324 | Structure-function studies on the cyclic peptide MT-II, lactam derivative of alpha-melanotropin |
| Q91742080 | Synergy between MC1R and ASIP for coat color in horses (Equus caballus)1 |
| Q34343356 | Synthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R). |
| Q38654515 | TRIENNIAL GROWTH AND DEVELOPMENT SYMPOSIUM: Factors influencing bovine intramuscular adipose tissue development and cellularity |
| Q28302831 | Targeted disruption of the melanocortin-4 receptor results in obesity in mice |
| Q47663380 | Targeted reduction of complex models with time scale hierarchy--a case study |
| Q89702631 | The "Extended Brown" Plumage Color Mutant of Blue-Breasted Quail (Coturnix chinensis) is Associated with a Mutation in the Melanocortin 1-Receptor Gene (MC1R) |
| Q34396769 | The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans. |
| Q33687989 | The Central Melanocortin System and Energy Homeostasis |
| Q34023834 | The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling |
| Q48110338 | The Leptin, Dopamine and Serotonin Receptors in Hypothalamic POMC-Neurons of Normal and Obese Rodents. |
| Q102141675 | The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases |
| Q28067395 | The Role of PVH Circuits in Leptin Action and Energy Balance |
| Q40870482 | The agouti-related protein decapeptide (Yc[CRFFNAFC]Y) possesses agonist activity at the murine melanocortin-1 receptor |
| Q47315738 | The alphabet of weight control |
| Q36135121 | The brain-adipose axis: a review of involvement of molecules |
| Q48199136 | The central melanocortin system regulates food intake in goldfish. |
| Q36327024 | The differential expression of MC1R regulators in dorsal and ventral quail plumages during embryogenesis: Implications for plumage pattern formation |
| Q64095130 | The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect |
| Q73523284 | The genetics of obesity |
| Q34492945 | The hypothalamus and the control of energy homeostasis: different circuits, different purposes |
| Q34039606 | The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box. |
| Q48086192 | The insertion of a full-length Bos taurus LINE element is responsible for a transcriptional deregulation of the Normande Agouti gene |
| Q41249144 | The interaction of agouti signal protein and melanocyte stimulating hormone to regulate melanin formation in mammals |
| Q48410557 | The long road to leptin |
| Q28594377 | The mahogany protein is a receptor involved in suppression of obesity |
| Q37087448 | The melanocortin 1 receptor and the UV response of human melanocytes--a shift in paradigm |
| Q45235653 | The melanocortin pathway: effects of voluntary exercise on the melanocortin-4 receptor knockout mice and ACTH(1-24) ligand structure activity relationships at the melanocortin-2 receptor |
| Q41769682 | The melanocortin receptors and their accessory proteins. |
| Q40604442 | The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs |
| Q36003378 | The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. |
| Q22009076 | The mouse mahogany locus encodes a transmembrane form of human attractin |
| Q34485124 | The mutation causing the black-and-tan pigmentation phenotype of Mangalitza pigs maps to the porcine ASIP locus but does not affect its coding sequence |
| Q40220162 | The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors |
| Q34117569 | The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice. |
| Q47429940 | The physiological function of the agouti-related peptide gene: the control of weight and metabolic rate |
| Q34254198 | The physiological role of melanocortin receptors |
| Q41172997 | The physiology and brain mechanisms of feeding |
| Q91911034 | The role of epigenetics in hypothalamic energy balance control: implications for obesity |
| Q34635467 | The role of melanocortins in body weight regulation: opportunities for the treatment of obesity |
| Q74604281 | The role of melanocortins in body weight regulation: opportunities for the treatment of obesity |
| Q34368934 | The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination |
| Q21245071 | The role of proopiomelanocortin (POMC) neurones in feeding behaviour |
| Q35140186 | The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models |
| Q33964758 | The structure and evolution of the melanocortin and MCH receptors in fish and mammals |
| Q36370929 | The transcriptional landscape of seasonal coat colour moult in the snowshoe hare. |
| Q33745873 | The yellow mouse obesity syndrome and mechanisms of agouti-induced obesity |
| Q62659539 | Thyrotropin-Releasing Hormone Selectively Stimulates Human Hair Follicle Pigmentation |
| Q38640885 | Toward a Wiring Diagram Understanding of Appetite Control |
| Q38307927 | Transcriptional regulation of the adipocyte fatty acid synthase gene by agouti: interaction with insulin |
| Q89793298 | Transcriptomic regulation of seasonal coat color change in hares |
| Q38387355 | Transcriptomics of colour patterning and coloration shifts in crows |
| Q43680758 | Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3. |
| Q34515580 | Transient ectopic overexpression of agouti-signalling protein 1 (asip1) induces pigment anomalies in flatfish |
| Q35813093 | Traveling stripes on the skin of a mutant mouse. |
| Q47605852 | Type 1 cannabinoid receptor modulates water deprivation-induced homeostatic responses |
| Q77735142 | Utilization of mouse models in the discovery of human disease genes |
| Q24312946 | Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans |
| Q37072395 | Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse |
| Q35351842 | WNIN/GR-Ob - an insulin-resistant obese rat model from inbred WNIN strain. |
| Q30859400 | Widespread expression of Agouti-related protein (AGRP) in the chicken: a possible involvement of AGRP in regulating peripheral melanocortin systems in the chicken |
| Q34590530 | Y chromosome of the inbred mouse KK/Ta strain is associated with reduced body size in Y-consomic strains |
| Q58735113 | Zebrafish as a Model for Obesity and Diabetes |
| Q91864626 | cAMP-mediated regulation of melanocyte genomic instability: A melanoma-preventive strategy |
| Q40647049 | gamma-MSH increases intracellular cAMP accumulation and GnRH release in vitro and LH release in vivo. |
| Q39656887 | γ2-Melanocyte stimulation hormone (γ2-MSH) truncation studies results in the cautionary note that γ2-MSH is not selective for the mouse MC3R over the mouse MC5R |
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