Skp1-Cul1-F-box ubiquitin ligase (SCF(βTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry

scientific article published on October 2012

Skp1-Cul1-F-box ubiquitin ligase (SCF(βTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.390328
P932PMC publication ID3493943
P698PubMed publication ID23027877
P5875ResearchGate publication ID231742500

P2093author name stringMatthew K Summers
Amy C Burrows
John Prokop
P2860cites workRole of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosomeQ24293506
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligaseQ24295177
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint responseQ24298620
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitorQ24300354
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entryQ24303864
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphaseQ24304123
Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1Q24306531
The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleusQ45240522
The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosisQ47889973
Neuronal and glioma-derived stem cell factor induces angiogenesis within the brainQ48583425
Defining the human deubiquitinating enzyme interaction landscapeQ24315885
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpointQ24317772
Identification of a physiological E2 module for the human anaphase-promoting complexQ24328862
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCPQ24329203
The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1Q24608202
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerQ24648025
Somatic mutations affect key pathways in lung adenocarcinomaQ24648102
Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphaseQ24683942
The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domainQ27642308
Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progressionQ28115063
Cyclin is degraded by the ubiquitin pathwayQ28131704
Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivoQ28177348
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damageQ28182301
Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligaseQ28249846
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complexQ28249855
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stressQ28255529
Dissection of USP catalytic domains reveals five common insertion pointsQ28257711
Dual mode of degradation of Cdc25 A phosphataseQ28386155
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpointQ28631721
Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substratesQ29616760
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signalingQ30414432
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1Q30477585
Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancersQ33285000
Stromal gene expression predicts clinical outcome in breast cancerQ33330931
Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish developmentQ33521127
Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliabilityQ33721845
Cell cycle-regulated expression, phosphorylation, and degradation of p55Cdc. A mammalian homolog of CDC20/Fizzy/slp1.Q34444604
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complexQ35081283
Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathwaysQ37262174
Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediatesQ37382258
Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.Q39983420
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.Q40488999
Survival prediction of stage I lung adenocarcinomas by expression of 10 genesQ42585784
The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC.Q42928048
P433issue46
P407language of work or nameEnglishQ1860
P304page(s)39021-39029
P577publication date2012-10-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleSkp1-Cul1-F-box ubiquitin ligase (SCF(βTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry
P478volume287

Reverse relations

cites work (P2860)
Q57666020A systems-wide screen identifies substrates of the SCF TrCP ubiquitin ligase
Q59807631Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity
Q89421745Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates
Q94452061Chk1-mediated phosphorylation of Cdh1 promotes the SCFβTRCP-dependent degradation of Cdh1 during S-phase and efficient cell-cycle progression
Q38695071Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint
Q38103253Decoding ubiquitin for mitosis
Q38719694FEM1 proteins are ancient regulators of SLBP degradation
Q41212579High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells
Q49720502Inhibition of neddylation pathway represses influenza virus replication and pro-inflammatory responses
Q26740196Insights into APC/C: from cellular function to diseases and therapeutics
Q28115646Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
Q52095907Regulation of USP37 Expression by REST-Associated G9a-Dependent Histone Methylation.
Q38959150Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity
Q30409927The HBx oncoprotein of hepatitis B virus deregulates the cell cycle by promoting the intracellular accumulation and re-compartmentalization of the cellular deubiquitinase USP37.
Q27932371The Ubp15 deubiquitinase promotes timely entry into S phase in Saccharomyces cerevisiae
Q38736908The expression of Cullin1 is increased in renal cell carcinoma and promotes cancer cell proliferation, migration, and invasion
Q28771759USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication
Q41889305Ubiquitin-interacting motifs confer full catalytic activity, but not ubiquitin chain substrate specificity, to deubiquitinating enzyme USP37.