Chemistry and biology of DNA methyltransferases

scientific article published on December 1996

Chemistry and biology of DNA methyltransferases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3109/10409239609108722
P698PubMed publication ID8994802
P5875ResearchGate publication ID14213150

P2093author name stringAhmad I
Rao DN
P2860cites workMechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylationQ24561686
Three-dimensional structure of the adenine-specific DNA methyltransferase M.Taq I in complex with the cofactor S-adenosylmethionineQ24562671
The DNA (cytosine-5) methyltransferasesQ24614934
Characterization of the cloned BamHI restriction modification system: its nucleotide sequence, properties of the methylase, and expression in heterologous hostsQ24633048
The crystal structure of Haelll methyltransferase covalently complexed to DNA: An extrahelical cytosine and rearranged base pairingQ27729758
HhaI methyltransferase flips its target base out of the DNA helixQ27731553
Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionineQ27731970
Atomic model of a pyrimidine dimer excision repair enzyme complexed with a DNA substrate: structural basis for damaged DNA recognitionQ27732192
IS10 transposition is regulated by DNA adenine methylationQ28286919
Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysisQ28298751
Cleavage of the bacteriophage P1 packaging site (pac) is regulated by adenine methylation.Q29031080
A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nucleiQ29616800
Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stabilityQ33859871
Premeiotic instability of repeated sequences in Neurospora crassaQ34179760
E. coli SeqA protein binds oriC in two different methyl-modulated reactions appropriate to its roles in DNA replication initiation and origin sequestrationQ34294934
Cytosine-specific type II DNA methyltransferases. A conserved enzyme core with variable target-recognizing domainsQ34525794
The replicative origin of the E. coli chromosome binds to cell membranes only when hemimethylatedQ34554813
Tyrosine 27 of the specificity polypeptide of EcoKI can be UV crosslinked to a bromodeoxyuridine-substituted DNA target sequenceQ34744985
HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repairQ34746885
DNA methyltransferasesQ40626444
Absence of expression of the FMR-1 gene in fragile X syndromeQ41669091
High frequency mutagenesis by a DNA methyltransferaseQ41917002
Proteins encoded by the DpnII restriction gene cassette. Two methylases and an endonucleaseQ43169724
Stereochemical studies of the C-methylation of deoxycytidine catalyzed by HhaI methylase and the N-methylation of deoxyadenosine catalyzed by EcoRI methylaseQ44539112
Facilitated diffusion of the EcoRI DNA methyltransferase is described by a novel mechanismQ46157592
5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylaseQ46224336
Contribution of facilitated diffusion and processive catalysis to enzyme efficiency: implications for the EcoRI restriction-modification systemQ46529890
Replication origin of the Escherichia coli K-12 chromosome: the size and structure of the minimum DNA segment carrying the information for autonomous replicationQ47296498
M.BssHII, a multispecific cytosine-C5-DNA-methyltransferase with unusual target recognizing propertiesQ48064752
Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyltransferases, and suggests a catalytic mechanism for these enzymesQ48069333
A hybrid recognition sequence in a recombinant restriction enzyme and the evolution of DNA sequence specificityQ50205462
Universal catalytic domain structure of AdoMet-dependent methyltransferases.Q53012595
Amino acid sequence arrangements of DNA-methyltransferasesQ53753431
Methylation patterns in pap regulatory DNA control pyelonephritis-associated pili phase variation in E. coli.Q54640621
A mutant HpaII methyltransferase functions as a mutator enzymeQ34778092
The cysteine conserved among DNA cytosine methylases is required for methyl transfer, but not for specific DNA bindingQ34962466
Cytosine deaminations catalyzed by DNA cytosine methyltransferases are unlikely to be the major cause of mutational hot spots at sites of cytosine methylation in Escherichia coliQ35059178
Conserved sequence motif DPPY in region IV of the phage T4 Dam DNA-[N-adenine]-methyltransferase is important for S-adenosyl-L-methionine bindingQ35858444
Methylation, mutation and cancerQ35911284
Agmenellum quadruplicatum M.AquI, a novel modification methylaseQ36156622
DNA methyltransferase-dependent transcription of the phage Mu mom geneQ36311907
Restriction and modification systemsQ37041891
DNA methylation and chromatin structureQ37191827
A structural taxonomy of DNA-binding domainsQ37483850
DNA methylation. The effect of minor bases on DNA-protein interactionsQ38140865
Probing the Protein-DNA Interface of the EcoRV Modification Methyltransferase Bound to Its Recognition Sequence, GATATCQ38292358
Sequence-Specific Binding of DNA by the EcoRV Restriction and Modification Enzymes with Nucleic Acid and Cofactor AnalogsQ38292360
Cytosine methyltransferase from Escherichia coli in which active site cysteine is replaced with serine is partially activeQ38293463
DNA recognition by the EcoP15I and EcoPI modification methyltransferasesQ38295255
Interaction of EcoP15I DNA methyltransferase with oligonucleotides containing the asymmetric sequence 5'-CAGCAG-3'.Q38304144
DNA recognition by the EcoK methyltransferase. The influence of DNA methylation and the cofactor S-adenosyl-L-methionineQ38314397
Binding of the EcoRII methyltransferase to 5-fluorocytosine-containing DNA. Isolation of a bound peptideQ38328039
Sequence-specific DNA binding by the MspI DNA methyltransferaseQ38328077
Purification and biochemical characterisation of theEcoR124 type I modification methylaseQ38330901
Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferaseQ38332274
Kinetic mechanism of the EcoRI DNA methyltransferaseQ38336068
Functional analysis of conserved motifs in EcoP15I DNA methyltransferaseQ38356849
Complementary specificity of restriction endonucleases of Diplococcus pneumoniae with respect to DNA methylationQ39165718
A model for initiation at origins of DNA replicationQ39256067
A bacterial methyltransferase M.EcoHK311 requires two proteins for in vitro methylation.Q40392566
Functional analysis of Gln-237 mutants of HhaI methyltransferaseQ40393086
M.HhaI binds tightly to substrates containing mismatches at the target baseQ40393755
Sequence-specific and mechanism-based crosslinking of Dcm DNA cytosine-C5 methyltransferase of E. coli K-12 to synthetic oligonucleotides containing 5-fluoro-2'-deoxycytidineQ40404791
The DNA binding affinity of HhaI methylase is increased by a single amino acid substitution in the catalytic centerQ40407238
The role of the preserved sequences of Dam methylaseQ40408315
Regulation of chromosomal replication in E. coli: sequestration and beyondQ40410575
Dam methyltransferase from Escherichia coli: sequence of a peptide segment involved in S-adenosyl-methionine bindingQ40415715
On base flippingQ40442261
Predictive motifs derived from cytosine methyltransferasesQ40448394
Structure and Function of DNA MethyltransferasesQ40475987
The sequence specificity domain of cytosine-C5 methylasesQ40508616
The double role of methyl donor and allosteric effector of S-adenosyl-methionine for Dam methylase of E. coliQ40518903
The CpG-specific methylase SssI has topoisomerase activity in the presence of Mg2+.Q40523164
How M.MspI and M.HpaII decide which base to methylateQ40534290
Cloning, characterization and heterologous expression of the SmaI restriction-modification systemQ40539601
P433issue5-6
P304page(s)361-380
P577publication date1996-12-01
P1433published inCritical Reviews in Biochemistry and Molecular BiologyQ5186661
P1476titleChemistry and biology of DNA methyltransferases
P478volume31

Reverse relations

cites work (P2860)
Q33851803ATP-dependent restriction enzymes
Q38295204Bacteriophage T4 Dam DNA-[N6-adenine]methyltransferase. Kinetic evidence for a catalytically essential conformational change in the ternary complex
Q38312858Biotin-avidin microplate assay for the quantitative analysis of enzymatic methylation of DNA by DNA methyltransferases
Q43151623Characterization of an N6 adenine methyltransferase from Helicobacter pylori strain 26695 which methylates adjacent adenines on the same strand.
Q28360668Chloroplast DNA methylation and inheritance in Chlamydomonas
Q44323352DNA (cytosine-N4-)- and -(adenine-N6-)-methyltransferases have different kinetic mechanisms but the same reaction route. A comparison of M.BamHI and T4 Dam.
Q37977119DNA methyltransferases: mechanistic models derived from kinetic analysis
Q36088271Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes
Q37698622Diversity of DNA methyltransferases that recognize asymmetric target sequences
Q52571195Functional analysis of amino acid residues at the dimerisation interface of KpnI DNA methyltransferase.
Q38336578Functional analysis of conserved motifs in type III restriction-modification enzymes
Q38336594Functional mapping of the EcoRV DNA methyltransferase by random mutagenesis and screening for catalytically inactive mutants
Q47892200Functional roles of conserved amino acid residues in DNA methyltransferases investigated by site-directed mutagenesis of the EcoRV adenine-N6-methyltransferase
Q44548818Identification and mutational analysis of Mg2+ binding site in EcoP15I DNA methyltransferase: involvement in target base eversion
Q93380766Kinetic and catalytic properties of M.HpyAXVII, a phase-variable DNA methyltransferase from Helicobacter pylori
Q44265593Kinetic and catalytic properties of dimeric KpnI DNA methyltransferase
Q28185955Mechanistic studies on the alkyltransferase activity of serotonin N-acetyltransferase
Q31467706Mutagenicity of nitrosamines in methyltransferase-deficient strains of Salmonella typhimurium coexpressing human cytochrome P450 2E1 and reductase
Q34045547Neisseria gonorrhoeae FA1090 carries genes encoding two classes of Vsr endonucleases
Q77195407Probing the role of cysteine residues in the EcoP15I DNA methyltransferase
Q24188041S-adenosyl-L-methionine for alcoholic liver diseases
Q24246175S-adenosyl-L-methionine for alcoholic liver diseases
Q30759150S-adenosyl-L-methionine for alcoholic liver diseases.
Q38308094Specificity of DNA binding and methylation by the M.FokI DNA methyltransferase
Q51608273Structure and dynamics of H. pylori 98-10 C5-cytosine specific DNA methyltransferase in complex with S-adenosyl-l-methionine and DNA.
Q36598928Structure, function and mechanism of exocyclic DNA methyltransferases
Q33918569The p53 gene in patients under the age of 40 with gastric cancer: mutation rates are low but are associated with a cardiac location
Q31798502Unnatural enantiomers of 5-azacytidine analogues: syntheses and enzymatic properties.
Q38294318Water-assisted dual mode cofactor recognition by HhaI DNA methyltransferase.