A hPMS2 mutant cell line is defective in strand-specific mismatch repair

scientific article published on August 1995

A hPMS2 mutant cell line is defective in strand-specific mismatch repair is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.270.31.18183
P698PubMed publication ID7629132
P5875ResearchGate publication ID15570280

P2093author name stringJ C Barrett
J I Risinger
T A Kunkel
A Umar
P2860cites workUbiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesisQ22122362
Mutations of two PMS homologues in hereditary nonpolyposis colon cancerQ24318484
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
Mutation of a mutL homolog in hereditary colon cancerQ28114939
Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genesQ28119040
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancerQ28256988
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancerQ28257360
Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutationsQ28299699
Microsatellite instability in cancer of the proximal colonQ29620692
Specificity of mismatch repair following transformation of Saccharomyces cerevisiae with heteroduplex plasmid DNA.Q33857769
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologsQ34554581
Mutator phenotypes in human colorectal carcinoma cell linesQ35568305
Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB.Q36182527
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.Q36412005
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL geneQ36643609
Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damageQ38320078
Mismatch repair, genetic stability, and cancerQ40556409
DNA damage tolerance, mismatch repair and genome instabilityQ40582064
Hypermutability and mismatch repair deficiency in RER+ tumor cellsQ41508298
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
Clues to the pathogenesis of familial colorectal cancerQ42622043
Mutagenesis of yeast MW104-1B strain has identified the uncharacterized PMS6 DNA mismatch repair gene locus and additional alleles of existing PMS1, PMS2 and MSH2 genesQ45976982
Mutations of the E-cadherin gene in human gynecologic cancersQ48082880
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancerQ48084125
A further tetranucleotide repeat polymorphism in the vWF geneQ48168540
Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancerQ58862199
P433issue31
P407language of work or nameEnglishQ1860
P921main subjectDNA mismatch repairQ2984243
P304page(s)18183-18186
P577publication date1995-08-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleA hPMS2 mutant cell line is defective in strand-specific mismatch repair
P478volume270

Reverse relations

cites work (P2860)
Q36540457A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair
Q44616192A single amino acid substitution in MSH5 results in DNA alkylation tolerance
Q28910215Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2
Q41617067Cancer cells exhibit a mutator phenotype
Q41005472Characterization of distinct human endometrial carcinoma cell lines deficient in mismatch repair that originated from a single tumor
Q74063639Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models
Q41174585Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line
Q40893852Cytotoxicity and mutagenicity of frameshift-inducing agent ICR191 in mismatch repair-deficient colon cancer cells
Q40939179DNA-mismatch repair. The intricacies of eukaryotic spell-checking
Q53365304Defective mismatch repair in the pathogenesis of low-grade appendiceal mucinous neoplasms and adenocarcinomas.
Q33888905Deficiency of a novel mismatch repair activity in a bladder tumor cell line
Q34478988Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells.
Q37522716Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct
Q58074493Human MutSα Specifically Binds to DNA Containing Aminofluorene and Acetylaminofluorene Adducts
Q36451916Human mismatch repair protein hMutLα is required to repair short slipped-DNAs of trinucleotide repeats
Q40920177Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1.
Q40022432Instability of CAG and CTG trinucleotide repeats in Saccharomyces cerevisiae
Q48065235MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2.
Q28510650Meiotic pachytene arrest in MLH1-deficient mice
Q41082110Mismatch repair defects and O6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells
Q53416148Mismatch repair, G(2)/M cell cycle arrest and lethality after DNA damage.
Q41005399Molecular events after antisense inhibition of hMSH2 in a HeLa cell line
Q40601230Msh2 deficiency does not contribute to cisplatin resistance in mouse embryonic stem cells
Q28592583Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
Q24318892Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair
Q34123282Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalpha
Q33909895Novel PMS2 pseudogenes can conceal recessive mutations causing a distinctive childhood cancer syndrome
Q40751829Preparation of DNA substrates for in vitro mismatch repair
Q36565271Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems
Q40969083Repair of large insertion/deletion heterologies in human nuclear extracts is directed by a 5' single-strand break and is independent of the mismatch repair system
Q38336291Requirement for DNA mismatch repair proteins in the transcription-coupled repair of thymine glycols in Saccharomyces cerevisiae
Q53437948Reversal of methylation tolerance by transfer of human chromosome 2.
Q30454407Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.
Q40878184Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability
Q40990759Specificity of mutations in the PMS2-deficient human tumor cell line HEC-1-A.
Q77413342Stability of microsatellites in myeloid neoplasias
Q41602506Strand-specific mismatch repair in mammalian cells
Q35753518The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different "target genes": a study of the TGFbeta RII, IGFII R, and BAX genes
Q31833517The instability within: problems in current analyses of microsatellite instability

Search more.