The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6.

scientific article published on 2 February 2015

The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NI.3097
P698PubMed publication ID25642822
P5875ResearchGate publication ID271773241

P50authorZhubing ShiQ57319761
P2093author name stringChen Wang
Min Chen
Xiaomin Song
Zhen Zhang
Min Huang
Catherine C L Wong
Wenjia Wang
Zhengfan Jiang
Hongyan Wang
Chuanchuan Li
Shi Jiao
Yanyan Wang
Yun Zhao
Zhaocai Zhou
Heng Liu
Chunyang Li
P2860cites workTAK1 is a ubiquitin-dependent kinase of MKK and IKKQ24291454
MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathwayQ24291824
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κBQ24294960
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signallingQ24299573
PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathwayQ24300270
CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerizationQ24301965
Distinct molecular mechanism for initiating TRAF6 signallingQ24302174
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMOQ24303248
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signalingQ24309107
The E3 ligase TRAF6 regulates Akt ubiquitination and activationQ24310343
A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancerQ24337135
Structural mechanism of CCM3 heterodimerization with GCKIII kinasesQ24337504
Molecular basis for CD40 signaling mediated by TRAF3Q24656208
Structure of the MST4 in complex with MO25 provides insights into its activation mechanismQ27684058
Structural basis for the unique heterodimeric assembly between cerebral cavernous malformation 3 and germinal center kinase IIIQ27684594
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chainQ28142613
A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alphaQ28187818
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family membersQ28201693
F4/80, a monoclonal antibody directed specifically against the mouse macrophageQ28281328
HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitinationQ28298562
Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liverQ28506478
The role of the Wnt family of secreted proteins in rat oval "stem" cell-based liver regeneration: Wnt1 drives differentiationQ28564657
The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptorsQ28589455
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathwaysQ28590675
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responsesQ29616349
Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex.Q30359226
Cloning and characterization of MST4, a novel Ste20-like kinaseQ30986864
MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signalingQ34420804
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Inhibition of influenza virus production in virus-infected mice by RNA interferenceQ34514513
A universal role for MyD88 in TLR/IL-1R-mediated signalingQ34825992
TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancerQ35370365
Inferences, questions and possibilities in Toll-like receptor signallingQ35829752
A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stressQ36917600
TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6.Q37593304
STRIPAK components determine mode of cancer cell migration and metastasis.Q37705440
Ubiquitin chain cleavage: CYLD at workQ37720057
A20: from ubiquitin editing to tumour suppressionQ37728850
Structure of MST2 SARAH domain provides insights into its interaction with RAPL.Q39030081
TRAF6 stimulates the tumor-promoting effects of TGFβ type I receptor through polyubiquitination and activation of presenilin 1.Q39036597
UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitinationQ39199690
TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.Q39532727
Negative feedback regulation of NF-κB action by CITED2 in the nucleusQ39628783
Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization.Q41960078
The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewalQ42744709
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complexQ42811211
Knockdown of connective tissue growth factor by plasmid-based short hairpin RNA prevented pulmonary vascular remodeling in cigarette smoke-exposed ratsQ44071361
Kinetics of TNF, IL-6, and IL-8 gene expression in LPS-stimulated human whole bloodQ68186537
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)246-257
P577publication date2015-02-02
P1433published inNature ImmunologyQ1071725
P1476titleThe kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6.
P478volume16

Reverse relations

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