Prostaglandin-endoperoxide synthase 2

human enzyme involved in inflammation

Wikidata entity: Q415364

Wikimedia Commons category is Cyclooxygenase 2



P682 biological process ... Q133500 (learning) learning
P682 biological process ... Q492 (memory) memory
P682 biological process ... Q187082 (ovulation) ovulation
P682 biological process ... Q332154 (ageing) ageing
P682 biological process ... Q539568 (angiogenesis) angiogenesis
P682 biological process ... Q1207365 (decidualization) decidualization
P682 biological process ... Q2792936 (lipid metabolism) lipid metabolism
P682 biological process ... Q2734305 (sensory perception of pain) sensory perception of pain
P682 biological process ... Q14916500 (NAD biosynthesis via nicotinamide riboside salvage pathway) NAD biosynthesis via nicotinamide riboside salvage pathway
P682 biological process ... Q15318015 (response to fructose) response to fructose
P682 biological process ... Q15318020 (positive regulation of synaptic plasticity) positive regulation of synaptic plasticity
P682 biological process ... Q15318025 (maintenance of blood-brain barrier) maintenance of blood-brain barrier
P682 biological process ... Q21095106 (cellular response to ATP) cellular response to ATP
P682 biological process ... Q21095280 (cellular response to fluid shear stress) cellular response to fluid shear stress
P682 biological process ... Q21111910 (positive regulation of fibroblast growth factor production) positive regulation of fibroblast growth factor production
P682 biological process ... Q21119071 (cellular response to lead ion) cellular response to lead ion
P682 biological process ... Q21123881 (positive regulation of platelet-derived growth factor production) positive regulation of platelet-derived growth factor production
P682 biological process ... Q21973641 (negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
P682 biological process ... Q14599399 (negative regulation of cell population proliferation) negative regulation of cell population proliferation
P682 biological process ... Q14599533 (negative regulation of apoptotic process) negative regulation of apoptotic process
P682 biological process ... Q14599551 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process) negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
P682 biological process ... Q14599693 (bone mineralization) bone mineralization
P682 biological process ... Q14599705 (response to vitamin D) response to vitamin D
P682 biological process ... Q14599713 (response to tumor necrosis factor) response to tumor necrosis factor
P682 biological process ... Q14633891 (positive regulation of cell population proliferation) positive regulation of cell population proliferation
P682 biological process ... Q14633902 (response to estradiol) response to estradiol
P682 biological process ... Q14758937 (positive regulation of nitric oxide biosynthetic process) positive regulation of nitric oxide biosynthetic process
P682 biological process ... Q14761977 (positive regulation of brown fat cell differentiation) positive regulation of brown fat cell differentiation
P682 biological process ... Q14818058 (cellular response to UV) cellular response to UV
P682 biological process ... Q14818063 (positive regulation of apoptotic process) positive regulation of apoptotic process
P682 biological process ... Q14818081 (cellular response to hypoxia) cellular response to hypoxia
P682 biological process ... Q14818120 (regulation of cell population proliferation) regulation of cell population proliferation
P682 biological process ... Q14819295 (brown fat cell differentiation) brown fat cell differentiation
P682 biological process ... Q14819786 (regulation of blood pressure) regulation of blood pressure
P682 biological process ... Q14819849 (inflammatory response) inflammatory response
P682 biological process ... Q14819863 (positive regulation of cell death) positive regulation of cell death
P682 biological process ... Q14820660 (positive regulation of prostaglandin biosynthetic process) positive regulation of prostaglandin biosynthetic process
P682 biological process ... Q14820663 (positive regulation of peptidyl-serine phosphorylation) positive regulation of peptidyl-serine phosphorylation
P682 biological process ... Q14820675 (positive regulation of vasoconstriction) positive regulation of vasoconstriction
P682 biological process ... Q14820897 (response to glucocorticoid) response to glucocorticoid
P682 biological process ... Q14820916 (response to organic cyclic compound) response to organic cyclic compound
P682 biological process ... Q14851954 (positive regulation of protein import into nucleus) positive regulation of protein import into nucleus
P682 biological process ... Q14852002 (embryo implantation) embryo implantation
P682 biological process ... Q14859645 (cellular response to mechanical stimulus) cellular response to mechanical stimulus
P682 biological process ... Q14860449 (fatty acid biosynthetic process) fatty acid biosynthetic process
P682 biological process ... Q14860517 (negative regulation of smooth muscle contraction) negative regulation of smooth muscle contraction
P682 biological process ... Q14860518 (regulation of inflammatory response) regulation of inflammatory response
P682 biological process ... Q14860535 (response to cytokine) response to cytokine
P682 biological process ... Q14860811 (negative regulation of synaptic transmission, dopaminergic) negative regulation of synaptic transmission, dopaminergic
P682 biological process ... Q14860867 (fatty acid metabolic process) fatty acid metabolic process
P682 biological process ... Q22271449 (cellular oxidant detoxification) cellular oxidant detoxification
P682 biological process ... Q22272306 (cellular response to non-ionic osmotic stress) cellular response to non-ionic osmotic stress
P682 biological process ... Q22273367 (response to angiotensin) response to angiotensin
P682 biological process ... Q22299435 (hair cycle) hair cycle
P682 biological process ... Q56058242 (regulation of neuroinflammatory response) regulation of neuroinflammatory response
P682 biological process ... Q14330834 (response to lipopolysaccharide) response to lipopolysaccharide
P682 biological process ... Q14331076 (positive regulation of synaptic transmission, glutamatergic) positive regulation of synaptic transmission, glutamatergic
P682 biological process ... Q14599315 (response to oxidative stress) response to oxidative stress
P682 biological process ... Q14861556 (response to organic substance) response to organic substance
P682 biological process ... Q14863107 (cytokine-mediated signaling pathway) cytokine-mediated signaling pathway
P682 biological process ... Q14863387 (response to radiation) response to radiation
P682 biological process ... Q14863701 (positive regulation of smooth muscle cell proliferation) positive regulation of smooth muscle cell proliferation
P682 biological process ... Q14864433 (response to organonitrogen compound) response to organonitrogen compound
P682 biological process ... Q14864775 (positive regulation of smooth muscle contraction) positive regulation of smooth muscle contraction
P682 biological process ... Q14864953 (positive regulation of transforming growth factor beta production) positive regulation of transforming growth factor beta production
P682 biological process ... Q14865182 (positive regulation of fever generation) positive regulation of fever generation
P682 biological process ... Q14873902 (negative regulation of calcium ion transport) negative regulation of calcium ion transport
P682 biological process ... Q14873927 (negative regulation of cell cycle) negative regulation of cell cycle
P682 biological process ... Q14874313 (positive regulation of vascular endothelial growth factor production) positive regulation of vascular endothelial growth factor production
P682 biological process ... Q14878196 (cellular response to heat) cellular response to heat
P682 biological process ... Q14881692 (cyclooxygenase pathway) cyclooxygenase pathway
P682 biological process ... Q14881696 (prostaglandin biosynthetic process) prostaglandin biosynthetic process
P682 biological process ... Q14881697 (prostaglandin metabolic process) prostaglandin metabolic process
P682 biological process ... Q14889543 (lipoxygenase pathway) lipoxygenase pathway
P682 biological process ... Q14902522 (response to lithium ion) response to lithium ion
P682 biological process ... Q14905605 (positive regulation of cell migration involved in sprouting angiogenesis) positive regulation of cell migration involved in sprouting angiogenesis
P682 biological process ... Q14907443 (response to fatty acid) response to fatty acid
P682 biological process ... Q14912010 (long-chain fatty acid biosynthetic process) long-chain fatty acid biosynthetic process
P682 biological process ... Q14913468 (response to manganese ion) response to manganese ion
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q79927 (endoplasmic reticulum) endoplasmic reticulum
P681 cell component ... Q1051872 (caveola) caveola
P681 cell component ... Q14633848 (endoplasmic reticulum lumen) endoplasmic reticulum lumen
P681 cell component ... Q14645640 (neuron projection) neuron projection
P681 cell component ... Q22325163 (protein-containing complex) protein-containing complex
P681 cell component ... Q14329032 (endoplasmic reticulum membrane) endoplasmic reticulum membrane
P681 cell component ... Q14349455 (membrane) membrane
P681 cell component ... Q14349519 (intracellular membrane-bounded organelle) intracellular membrane-bounded organelle
P681 cell component ... Q14878067 (organelle membrane) organelle membrane
P373 Commons category String Cyclooxygenase 2 ???
P591 EC enzyme number String 1.14.99.1 ???
P702 encoded by ... Q20970156 (PTGS2) PTGS2
P2888 exact match Url UniProt ???
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P527 has part(s) ... Q24723491 (EGF-like domain) EGF-like domain
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q13667380 (metal ion binding) metal ion binding
P680 molecular function ... Q15318004 (prostaglandin-endoperoxide synthase activity) prostaglandin-endoperoxide synthase activity
P680 molecular function ... Q15318008 (arachidonate 15-lipoxygenase activity) arachidonate 15-lipoxygenase activity
P680 molecular function ... Q21097279 (dioxygenase activity) dioxygenase activity
P680 molecular function ... Q14762996 (protein homodimerization activity) protein homodimerization activity
P680 molecular function ... Q14819650 (peroxidase activity) peroxidase activity
P680 molecular function ... Q14840131 (transferase activity) transferase activity
P680 molecular function ... Q14349613 (oxidoreductase activity) oxidoreductase activity
P680 molecular function ... Q14358516 (heme binding) heme binding
P680 molecular function ... Q14599289 (enzyme binding) enzyme binding
P680 molecular function ... Q14907416 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
P361 part of ... Q24773605 (Haem peroxidase superfamily) Haem peroxidase superfamily
P361 part of ... Q24775958 (Prostaglandin G/H synthase 2) Prostaglandin G/H synthase 2
P361 part of ... Q41798207 (Haem peroxidase domain superfamily, animal type) Haem peroxidase domain superfamily, animal type
P361 part of ... Q83134378 (EGF-like domain, protein family) EGF-like domain, protein family
P129 physically interacts with ... Q18216 (aspirin) aspirin
P129 physically interacts with ... Q186969 (ibuprofen) ibuprofen
P129 physically interacts with ... Q244408 (Diclofenac) Diclofenac
P129 physically interacts with ... Q413744 (lumiracoxib) lumiracoxib
P129 physically interacts with ... Q414028 (meloxicam) meloxicam
P129 physically interacts with ... Q419890 ((±)-flurbiprofen) (±)-flurbiprofen
P129 physically interacts with ... Q407329 (resveratrol) resveratrol
P129 physically interacts with ... Q408676 (piroxicam) piroxicam
P129 physically interacts with ... Q347613 (valdecoxib) valdecoxib
P129 physically interacts with ... Q421342 (phenylbutazone) phenylbutazone
P129 physically interacts with ... Q631202 (etoricoxib) etoricoxib
P129 physically interacts with ... Q20994 (nimesulide) nimesulide
P129 physically interacts with ... Q57055 (paracetamol) paracetamol
P129 physically interacts with ... Q408801 (celecoxib) celecoxib
P129 physically interacts with ... Q409192 ((RS)-ketoprofen) (RS)-ketoprofen
P129 physically interacts with ... Q411412 (rofecoxib) rofecoxib
P129 physically interacts with ... Q905755 (carprofen) carprofen
P129 physically interacts with ... Q1215575 (naproxen) naproxen
P129 physically interacts with ... Q2823284 (meclofenamic acid) meclofenamic acid
P129 physically interacts with ... Q3978097 (suprofen) suprofen
P129 physically interacts with ... Q4890814 (benzquinamide) benzquinamide
P129 physically interacts with ... Q6955228 (NS-398) NS-398
P129 physically interacts with ... Q12430631 (diclofenac sodium) diclofenac sodium
P129 physically interacts with ... Q13575264 (iguratimod) iguratimod
P129 physically interacts with ... Q2555245 ((RS)-fenoprofen) (RS)-fenoprofen
P129 physically interacts with ... Q2602750 (diflunisal) diflunisal
P129 physically interacts with ... Q18209480 (apricoxib) apricoxib
P129 physically interacts with ... Q19598695 (polmacoxib) polmacoxib
P129 physically interacts with ... Q284321 (mefenamic acid) mefenamic acid
P129 physically interacts with ... Q1749609 (oxaprozin) oxaprozin
P129 physically interacts with ... Q2014797 (ketorolac) ketorolac
P129 physically interacts with ... Q2465218 ((RS)-etodolac) (RS)-etodolac
P129 physically interacts with ... Q2487682 (bromfenac) bromfenac
P129 physically interacts with ... Q22075801 (isoxicam) isoxicam
P129 physically interacts with ... Q27104495 (esflurbiprofen) esflurbiprofen
P129 physically interacts with ... Q27106401 (diclofenac potassium) diclofenac potassium
P129 physically interacts with ... Q27106616 ((RS)-fenoprofen calcium dihydrate) (RS)-fenoprofen calcium dihydrate
P129 physically interacts with ... Q27107089 (ketorolac tromethamine) ketorolac tromethamine
P129 physically interacts with ... Q27107504 (naproxen sodium) naproxen sodium
P129 physically interacts with ... Q27108450 (tolmetin sodium) tolmetin sodium

External Ids
P1417Encyclopædia Britannica Online IDscience/cyclooxygenase-2
P705Ensembl protein IDENSP00000356438
P705Ensembl protein IDENSP00000454130
P646Freebase ID/m/02x2zj9
P354HGNC ID9605
P6366Microsoft Academic ID (discontinued)2777350520
P691NL CR AUT IDph430281
P638PDB structure ID5F19
P638PDB structure ID5IKR
P638PDB structure ID5IKQ
P638PDB structure ID5F1A
P638PDB structure ID5IKT
P638PDB structure ID5IKV
P637RefSeq protein IDNP_000954
P352UniProt protein IDP35354

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