Simultaneous presence of p47(phox) and flavocytochrome b-245 are required for the activation of NADPH oxidase by anionic amphiphiles. Evidence for an intermediate state of oxidase activation

scientific article published on May 1999

Simultaneous presence of p47(phox) and flavocytochrome b-245 are required for the activation of NADPH oxidase by anionic amphiphiles. Evidence for an intermediate state of oxidase activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.274.22.15519
P698PubMed publication ID10336445

P2093author name stringCurnutte JT
Cross AR
Erickson RW
P2860cites workStudies on the electron-transfer mechanism of the human neutrophil NADPH oxidaseQ42018615
The superoxide-generating oxidase of leucocytes. NADPH-dependent reduction of flavin and cytochrome b in solubilized preparationsQ42848233
Mechanism of the superoxide-producing oxidase of neutrophils. O2 is necessary for the fast reduction of cytochrome b-245 by NADPH.Q42849301
The cytochrome b and flavin content and properties of the O2- -forming NADPH oxidase solubilized from activated neutrophilsQ46220634
The cytosolic activating factors p47phox and p67phox have distinct roles in the regulation of electron flow in NADPH oxidaseQ46518541
Aerobic and anaerobic functioning of superoxide-producing cytochrome b-559 reconstituted with phospholipidsQ46598846
Cytochrome b-245 of the neutrophil superoxide-generating system contains two nonidentical hemes. Potentiometric studies of a mutant form of gp91phoxQ46652773
p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domainsQ24324646
A novel cytosolic component, p40phox, of respiratory burst oxidase associates with p67phox and is absent in patients with chronic granulomatous disease who lack p67phoxQ28251613
Anionic amphiphile-independent activation of the phagocyte NADPH oxidase in a cell-free system by p47phox and p67phox, both in C terminally truncated forms. Implication for regulatory Src homology 3 domain-mediated interactions.Q30176265
NADPH oxidase activity is independent of p47phox in vitroQ30176826
Conformational changes of the leukocyte NADPH oxidase subunit p47(phox) during activation studied through its intrinsic fluorescenceQ30431493
Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activationQ34244747
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agentQ34501431
Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytesQ41619617
Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase.Q41620128
The enzymic reduction and kinetics of oxidation of cytochrome b-245 of neutrophilsQ41760676
Spontaneous activation of NADPH oxidase in a cell-free system: unexpected multiple effects of magnesium ion concentrationsQ41824564
P433issue22
P407language of work or nameEnglishQ1860
P304page(s)15519-15525
P577publication date1999-05-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleSimultaneous presence of p47(phox) and flavocytochrome b-245 are required for the activation of NADPH oxidase by anionic amphiphiles. Evidence for an intermediate state of oxidase activation
P478volume274

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cites work (P2860)
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Q91624186A thermodynamically-constrained mathematical model for the kinetics and regulation of NADPH oxidase 2 complex-mediated electron transfer and superoxide production
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Q24303790Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent alpha-helix of p22phox
Q30175140Arachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidase
Q35918569Ceramide kinase regulates TNFα-stimulated NADPH oxidase activity and eicosanoid biosynthesis in neuroblastoma cells
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Q40674156Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox
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Q43918731Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent.
Q30495822SHIP-1 increases early oxidative burst and regulates phagosome maturation in macrophages
Q59942389Structural changes are induced in human neutrophil cytochrome b by NADPH oxidase activators, LDS, SDS, and arachidonate: intermolecular resonance energy transfer between trisulfopyrenyl-wheat germ agglutinin and cytochrome b558
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Q42996911p40(phox) Participates in the activation of NADPH oxidase by increasing the affinity of p47(phox) for flavocytochrome b(558).

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