Metabolic Origins of Heart Failure.

scientific article published on June 2017

Metabolic Origins of Heart Failure. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JACBTS.2016.11.009
P932PMC publication ID5609457
P698PubMed publication ID28944310

P50authorManoja K BrahmaQ64682485
Graham R. McGinnisQ41500050
P2093author name stringAdam R Wende
Martin E Young
P2860cites workMechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant productionQ84405012
Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failureQ44082558
Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in miceQ44179204
Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopyQ44182277
Very-long-chain acyl-coenzyme a dehydrogenase deficiency in miceQ44534251
Defective myocardial carnitine metabolism in congestive heart failure secondary to dilated cardiomyopathy and to coronary, hypertensive and valvular heart diseasesQ44781340
Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemiaQ44801333
Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overloadQ44927100
Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathyQ45200908
Hypercatabolic syndrome: molecular basis and effects of nutritional supplements with amino acidsQ46565780
Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophyQ46648922
Decreased contractile and metabolic reserve in peroxisome proliferator-activated receptor-alpha-null hearts can be rescued by increasing glucose transport and utilizationQ46735147
Exhaled acetone as a new biomaker of heart failure severityQ48653946
Development and pathomechanisms of cardiomyopathy in very long-chain acyl-CoA dehydrogenase deficient (VLCAD(-/-)) miceQ50688253
Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heartQ50782443
Effect of partial inhibition of fatty acid oxidation by trimetazidine on whole body energy metabolism in patients with chronic heart failureQ51025352
Exhaled Acetone Concentration Is Related to Hemodynamic Severity in Patients With Non-Ischemic Chronic Heart FailureQ51536590
Metabolic Staging in Human Heart Failure: Circulating Acylcarnitines and the Failing Heart's Energetic SignatureQ51551304
Impaired energy metabolism of the taurine‑deficient heartQ51582758
Low carbohydrate ketogenic diet enhances cardiac tolerance to global ischaemiaQ53529577
Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in miceQ54609364
A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidationQ55043340
Effect of taurine supplementation on exercise capacity of patients with heart failure.Q55053971
Branched-chain amino acids ameliorate heart failure with cardiac cachexia in rats.Q55053981
Role of protein phosphorylation in excitation-contraction coupling in taurine deficient hearts.Q55069898
Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunctionQ57396503
Pathophysiology of chronic heart failureQ67518120
Usefulness of taurine in chronic congestive heart failure and its prospective applicationQ68061936
Effects of moderate hypertension on cardiac function and metabolism in the rabbitQ68347187
Increased glycolytic metabolism in cardiac hypertrophy and congestive failureQ68447663
Breath acetone in congestive heart failureQ71551032
Fatty acid oxidation enzyme gene expression is downregulated in the failing heartQ71828329
Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied heartsQ72144367
Altered coenzyme A and carnitine metabolism in pressure-overload hypertrophied heartsQ72786969
Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanismsQ73035986
Heart failure ketosisQ73830470
Apoptotic versus autophagic cell death in heart failureQ74257419
Regulation of Energy Metabolism of the Heart during Acute Increase in Heart WorkQ77477972
Glucose for the heartQ77932890
Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heartQ79224445
Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertensionQ79294443
Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse heart as measured by NMR spectroscopyQ79871363
Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathyQ80979295
High-fat diet prevents cardiac hypertrophy and improves contractile function in the hypertensive dahl salt-sensitive ratQ81239486
Oral amino acid supplements improve exercise capacities in elderly patients with chronic heart failureQ81365268
Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failureQ82736120
Mitochondrion as a Target for Heart Failure Therapy- Role of Protein Lysine AcetylationQ26801419
Pyridine Nucleotide Regulation of Cardiac Intermediary MetabolismQ26822692
Remodeling of glucose metabolism precedes pressure overload-induced left ventricular hypertrophy: review of a hypothesisQ26853332
Glucose Transporters in Cardiac Metabolism and HypertrophyQ28075863
Ubiquitin proteasome dysfunction in human hypertrophic and dilated cardiomyopathiesQ28273319
Regulation of signal transduction by reactive oxygen species in the cardiovascular systemQ28391569
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stressQ28506886
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)Q28512084
Insulin Signaling and Heart Failure.Q30377910
Post-translational modifications of the cardiac proteome in diabetes and heart failureQ33361067
GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure.Q33680469
High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats.Q34062837
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.Q34117304
PPAR signaling in the control of cardiac energy metabolismQ34204732
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitorQ34316485
Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular diseaseQ34317717
Allopurinol Acutely Increases Adenosine Triphospate Energy Delivery in Failing Human HeartsQ34398552
Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling.Q34404106
Wasting as independent risk factor for mortality in chronic heart failureQ34421966
Cardiomyocyte aldose reductase causes heart failure and impairs recovery from ischemia.Q34431401
Myocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humansQ34557869
Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approachQ34559786
Protein O-GlcNAcylation and cardiovascular (patho)physiologyQ34683061
Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophyQ34742779
G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.Q35041039
Plasma amino acid profiling identifies specific amino acid associations with cardiovascular function in patients with systolic heart failureQ35058430
Assessment of myocardial fatty acid metabolic abnormalities in patients with idiopathic dilated cardiomyopathy using 123I BMIPP SPECT: correlation with clinicopathological findings and clinical courseQ35370515
Altered systemic ketone body metabolism in advanced heart failureQ35594825
Metabolomic fingerprint of heart failure with preserved ejection fractionQ35641415
Expression of SGLT1 in Human Hearts and Impairment of Cardiac Glucose Uptake by Phlorizin during Ischemia-Reperfusion Injury in MiceQ35677381
Cardiac autophagy is a maladaptive response to hemodynamic stressQ35839989
Impaired glucose metabolism in patients with heart failure: pathophysiology and possible treatment strategiesQ35902401
Dietary fat and heart failure: moving from lipotoxicity to lipoprotection.Q35974413
Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a reviewQ35980293
A novel mouse model of lipotoxic cardiomyopathyQ36016938
Normalizing the metabolic phenotype after myocardial infarction: impact of subchronic high fat feedingQ36024334
Fatty acid oxidation inhibitors in the management of chronic complications of atherosclerosisQ36026001
Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle.Q36104643
Insulin resistance improves metabolic and contractile efficiency in stressed rat heartQ36117453
GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricleQ36156657
Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophyQ36211992
Peroxisome Proliferator Activated Receptor-α Association With Silent Information Regulator 1 Suppresses Cardiac Fatty Acid Metabolism in the Failing HeartQ36296771
Feeding the fibrillating heart: Dichloroacetate improves cardiac contractile dysfunction following VF.Q36339422
Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicityQ36359620
Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytesQ36385967
The Failing Heart Relies on Ketone Bodies as a FuelQ36614537
Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.Q36654675
Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure.Q36739432
Ketone body metabolism and cardiovascular diseaseQ36764435
The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasisQ36807931
Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification.Q36869450
Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureQ36932534
Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablationQ37032295
A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overloadQ37038725
Low carbohydrate diet decreases myocardial insulin signaling and increases susceptibility to myocardial ischemiaQ37097785
Control of lipolysis by natriuretic peptides and cyclic GMP.Q37109051
Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylationQ37193340
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylationQ37241211
Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male miceQ37249085
Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction.Q37328748
SGLT1 is a novel cardiac glucose transporter that is perturbed in disease statesQ37341063
Loss of the eukaryotic initiation factor 2α kinase general control nonderepressible 2 protects mice from pressure overload-induced congestive heart failure without affecting ventricular hypertrophy.Q37365394
Impaired assembly and post-translational regulation of 26S proteasome in human end-stage heart failureQ37396042
Markers of autophagy are downregulated in failing human heart after mechanical unloadingQ37423543
Cardiac-specific VLCAD deficiency induces dilated cardiomyopathy and cold intoleranceQ37575903
O-GlcNAc and the cardiovascular system.Q37619691
The adrenergic-fatty acid load in heart failureQ37619839
Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heartQ37629277
Myocardial fatty acid metabolism in health and diseaseQ37677921
Atrial natriuretic peptides in heart failure: pathophysiological significance, diagnostic and prognostic valueQ37909469
Additional use of trimetazidine in patients with chronic heart failure: a meta-analysisQ37989678
Glucose-insulin-potassium revived: current status in acute coronary syndromes and the energy-depleted heartQ38086415
Cardiac sarcoplasmic reticulum calcium leak: basis and roles in cardiac dysfunction.Q38163601
Amino acids and derivatives, a new treatment of chronic heart failure?Q38219915
Nutrient regulation of signaling, transcription, and cell physiology by O-GlcNAcylation.Q38237575
Impact of diabetes on epidemiology, treatment, and outcomes of patients with heart failureQ38347423
Good and bad consequences of altered fatty acid metabolism in heart failure: evidence from mouse modelsQ38375945
Myocardial metabolism in diabetic cardiomyopathy: potential therapeutic targetsQ38390699
Rationale and benefits of trimetazidine by acting on cardiac metabolism in heart failureQ38652938
Impact of empagliflozin in patients with diabetes and heart failureQ38822815
Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.Q38912082
Presentation blood glucose and death, hospitalization, and future diabetes risk in patients with acute heart failure syndromes.Q39062440
Molecular profiling of dilated cardiomyopathy that progresses to heart failureQ39726366
Effects of oral amino Acid supplements on functional capacity in patients with chronic heart failureQ40086861
Regulation of fatty acid oxidation in the mammalian heart in health and diseaseQ40682538
Elevated serum glucose levels and survival after acute heart failure: a population-based perspectiveQ41668688
Carnitine — from cellular mechanisms to potential clinical applications in heart diseaseQ41702188
Augmented O-GlcNAc signaling attenuates oxidative stress and calcium overload in cardiomyocytes.Q41767266
Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.Q42818693
Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling.Q42863016
Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failureQ42928039
Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failureQ43153623
Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overloadQ43207763
Responses of GLUT4-deficient hearts to ischemia underscore the importance of glycolysisQ43645320
Metabolic Gene Expression in Fetal and Failing Human HeartQ43819742
Successful treatment of severe cardiomyopathy in glycogen storage disease type III With D,L-3-hydroxybutyrate, ketogenic and high-protein dietQ43868499
Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy.Q44054769
P433issue3
P304page(s)297-310
P577publication date2017-06-01
P1433published inJACC. Basic to Translational ScienceQ27727237
P1476titleMetabolic Origins of Heart Failure
P478volume2

Reverse relations

cites work (P2860)
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