Cdt2-mediated XPG degradation promotes gap-filling DNA synthesis in nucleotide excision repair

scientific article published on January 2015

Cdt2-mediated XPG degradation promotes gap-filling DNA synthesis in nucleotide excision repair is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/15384101.2014.973740
P932PMC publication ID4614405
P698PubMed publication ID25483071

P2093author name stringJiang Qian
Nidhi Sharma
Chunhua Han
Altaf A Wani
Gulzar Wani
Qianzheng Zhu
Ran Zhao
Qi-En Wang
Jinshan He
P2860cites workDDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complexQ34409053
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.Q34417183
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sitesQ34479820
Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligaseQ35237385
Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repairQ36059498
Mechanism of release and fate of excised oligonucleotides during nucleotide excision repairQ36080510
Molecular mechanisms of mammalian global genome nucleotide excision repair.Q36389623
Nucleotide excision repair in human cells: fate of the excised oligonucleotide carrying DNA damage in vivoQ37175091
UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II.Q37249463
XPG: its products and biological rolesQ37380912
Definition of a short region of XPG necessary for TFIIH interaction and stable recruitment to sites of UV damageQ37684033
Protein degradation in DNA damage responseQ37986903
c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the re-synthesis of XPFQ38307306
Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC.Q38315128
Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG proteinQ38348603
Recruitment of the nucleotide excision repair endonuclease XPG to sites of UV-induced dna damage depends on functional TFIIH.Q39127506
XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genesQ39318398
Delayed c-Fos activation in human cells triggers XPF induction and an adaptive response to UVC-induced DNA damage and cytotoxicityQ39639823
Spatiotemporal dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigenQ40301471
Reconstitution of human DNA repair excision nuclease in a highly defined systemQ41370395
UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repairQ42448366
UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2.Q45345103
Antibodies to UV irradiated DNA: the monitoring of DNA damage by ELISA and indirect immunofluorescenceQ70398451
PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replicationQ81640024
Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sitesQ22254369
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damageQ24301297
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpointQ24312094
Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repairQ24312736
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complexQ24312855
The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21Q24313616
Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) proteinQ24317182
Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanningQ24321848
Human DNA repair excision nuclease. Analysis of the roles of the subunits involved in dual incisions by using anti-XPG and anti-ERCC1 antibodiesQ24336495
Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAKQ24609992
The comings and goings of nucleotide excision repair factors on damaged DNAQ24672395
Requirement of yeast RAD2, a homolog of human XPG gene, for efficient RNA polymerase II transcription. implications for Cockayne syndromeQ27933687
A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phaseQ28295980
Sequential assembly of the nucleotide excision repair factors in vivoQ28610121
Direct observation of individual endogenous protein complexes in situ by proximity ligationQ29616032
Dynamic recruitment of licensing factor Cdt1 to sites of DNA damageQ30995725
Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damageQ31140487
The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions.Q31157514
Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step.Q33310274
Nucleotide excision repair: new tricks with old bricksQ33353971
TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylationQ33409253
Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells.Q33712618
Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair.Q33840056
The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cellsQ34012408
In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene productQ34226018
Overexpression of DDB2 enhances the sensitivity of human ovarian cancer cells to cisplatin by augmenting cellular apoptosisQ34267584
P433issue7
P1104number of pages13
P304page(s)1103-1115
P577publication date2015-01-01
P1433published inCell CycleQ1254166
P1476titleCdt2-mediated XPG degradation promotes gap-filling DNA synthesis in nucleotide excision repair
P478volume14

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cites work (P2860)
Q37220505Differential DNA lesion formation and repair in heterochromatin and euchromatin
Q60924153Direct binding of Cdt2 to PCNA is important for targeting the CRL4 E3 ligase activity to Cdt1
Q39117841Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork
Q47664949Maternal DCAF2 is crucial for maintenance of genome stability during the first cell cycle in mice
Q38958950PostExcision Events in Human Nucleotide Excision Repair
Q42635576Screening and identification of critical transcription factors involved in the protection of cardiomyocytes against hydrogen peroxide-induced damage by Yixin-shu
Q27322859Sequential replication-coupled destruction at G1/S ensures genome stability.
Q36419741TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism
Q28070128Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation
Q47692635UV radiation-induced SUMOylation of DDB2 regulates nucleotide excision repair

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