Targeting tat inhibitors in the assembly of human immunodeficiency virus type 1 transcription complexes

scientific article published on 30 July 2008

Targeting tat inhibitors in the assembly of human immunodeficiency virus type 1 transcription complexes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00763-08
P932PMC publication ID2546947
P698PubMed publication ID18667497
P5875ResearchGate publication ID23137901

P2093author name stringAlan D Frankel
Iván D'Orso
Jocelyn R Grunwell
Robert L Nakamura
Chandreyee Das
P2860cites workA human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat.Q24302596
The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzymeQ24646774
HIV-1 Tat stimulates transcription complex assembly through recruitment of TBP in the absence of TAFsQ24797317
Differential recruitment of pre-mRNA splicing factors to alternatively spliced transcripts in vivoQ24814750
Tat gets the "green" light on transcription initiationQ24815711
The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexesQ27939585
Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcriptionQ28131686
Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another proteinQ28247468
Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activatorsQ28249621
Controlling the elongation phase of transcription with P-TEFbQ28255518
Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3' end processingQ29614768
Implications of macromolecular crowding for protein assembly.Q30326202
Screening RNA-binding libraries using Tat-fusion system in mammalian cellsQ30651338
Interaction of U2AF65 RS region with pre-mRNA branch point and promotion of base pairing with U2 snRNA [corrected]Q71468310
Imposing specificity by localization: mechanism and evolvabilityQ77565684
RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivoQ77962891
A novel glutamine-RNA interaction identified by screening libraries in mammalian cellsQ32068514
Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversityQ33220546
Kinetics of p53 binding to promoter sites in vivoQ33558659
A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeatQ33662926
The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.Q33780734
Inhibition of human immunodeficiency virus type 1 Tat activity by coexpression of heterologous trans activatorsQ33930741
A human RNA polymerase II-containing complex associated with factors necessary for spliceosome assemblyQ33956679
Recognition of RNA branch point sequences by the KH domain of splicing factor 1 (mammalian branch point binding protein) in a splicing factor complexQ33969114
A conserved mRNA export machinery coupled to pre-mRNA splicingQ34120025
Trans-activation by HIV-1 Tat via a heterologous RNA binding proteinQ34156002
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factorsQ34419716
High transdominant RevM10 protein levels are required to inhibit HIV-1 replication in cell lines and primary T cells: implication for gene therapy of AIDS.Q34420162
Replication of human immunodeficiency viruses engineered with heterologous Tat-transactivation response element interactionsQ34467420
Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional programQ34471112
The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 proteinQ35211232
A 10 residue motif at the C-terminus of the RNA pol II CTD is required for transcription, splicing and 3' end processing.Q35561598
Structure and mechanism of the RNA polymerase II transcription machineryQ35758805
RNA polymerase II structure: from core to functional complexesQ35804643
Inhibition of human immunodeficiency virus type 1 and type 2 Tat function by transdominant Tat protein localized to both the nucleus and cytoplasmQ35872597
Multiple links between transcription and splicingQ35895223
The multifactorial nature of HIV-1 latencyQ35935335
RS domains contact the pre-mRNA throughout spliceosome assemblyQ36064219
Transcription Factor and Polymerase Recruitment, Modification, and Movement on dhsp70 In Vivo in the Minutes following Heat ShockQ36139169
Targeting of U2AF65 to sites of active splicing in the nucleusQ36262035
Beyond the sequence: cellular organization of genome functionQ36744492
Functional inactivation of genes by dominant negative mutationsQ38178605
Newly Initiated RNA encounters a factor involved in splicing immediately upon emerging from within RNA polymerase II.Q38336471
SR proteins function in coupling RNAP II transcription to pre-mRNA splicing.Q40115980
Transdominant negative mutationsQ40929001
Inhibition of Tat-mediated transactivation and HIV replication with Tat mutant and repressor domain fusion proteinsQ40995031
Determination of the minimal amount of Tat activity required for human immunodeficiency virus type 1 replicationQ41081547
Inhibition of HIV-1 replication and reactivation from latency by tat transdominant negative mutants in the cysteine rich region.Q41222921
RNA polymerase II C-terminal domain required for enhancer-driven transcriptionQ41350631
NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiationQ42128724
Mutational analysis of HIV-1 Tat minimal domain peptides: identification of trans-dominant mutants that suppress HIV-LTR-driven gene expressionQ44389543
Expression of a truncated viral trans-activator selectively impedes lytic infection by its cognate virusQ45841020
HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virusQ45843803
Negative effect of the transcriptional activator GAL4Q59072863
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)9492-9504
P577publication date2008-07-30
P1433published inJournal of VirologyQ1251128
P1476titleTargeting tat inhibitors in the assembly of human immunodeficiency virus type 1 transcription complexes
P478volume82

Reverse relations

cites work (P2860)
Q34992613Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes
Q39194586Can the HIV-1 splicing machinery be targeted for drug discovery?
Q36148507Impact of Tat Genetic Variation on HIV-1 Disease
Q42027880RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation
Q38212101Strategies to Block HIV Transcription: Focus on Small Molecule Tat Inhibitors
Q37820252Targeting the protein-protein interactions of the HIV lifecycle
Q37117705Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex
Q39272683Transition step during assembly of HIV Tat:P-TEFb transcription complexes and transfer to TAR RNA.

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