Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation

scientific article published on 11 January 2012

Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M111.331645
P932PMC publication ID3318697
P698PubMed publication ID22238343

P50authorGraham D. PavittQ38319672
P2093author name stringSarah S Mohammad-Qureshi
Peter J Reid
P2860cites workThe CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis toolsQ24248165
Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse waysQ24323177
Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formationQ24554201
ModBase, a database of annotated comparative protein structure models, and associated resourcesQ24613729
Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activityQ24629691
Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2Q24647789
The SWISS-MODEL Repository and associated resourcesQ24656047
Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by analysis of conserved sequence motifsQ24675018
Assessment of aryl hydrocarbon receptor complex interactions using pBEVY plasmids: expressionvectors with bi-directional promoters for use in Saccharomyces cerevisiae.Q39251158
Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogasterQ40845242
Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.Q42412345
Severity of vanishing white matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexes.Q45945811
Catalysis of guanine nucleotide exchange on eIF-2 by eIF-2B: is it a sequential or substituted enzyme mechanism?Q73821775
Purification and kinetic analysis of eIF2B from Saccharomyces cerevisiaeQ73893684
Catalysis of guanine nucleotide exchange on eIF2 by eIF2B: can it be both a substituted enzyme and a sequential mechanism?Q77299634
Invasion of the nucleotide snatchers: structural insights into the mechanism of G protein GEFsQ77470794
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunitsQ24810130
Crystal structure of the bifunctional N-acetylglucosamine 1-phosphate uridyltransferase from Escherichia coli: a paradigm for the related pyrophosphorylase superfamilyQ27619240
Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residueQ27642799
Crystal structure of the alpha subunit of human translation initiation factor 2BQ27656719
eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.Q27930296
eIF5 has GDI activity necessary for translational control by eIF2 phosphorylationQ27931061
Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiationQ27934320
Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3.Q27935870
Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiaeQ27937984
Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.Q27938220
Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formationQ28138606
The guanine nucleotide-exchange factor, eIF-2BQ28236520
Eukaryotic initiation factor 2B (eIF2B) GEF activity as a diagnostic tool for EIF2B-related disordersQ28472229
Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cellsQ28564610
Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alpha- and delta-subunits of eiF2bQ28572395
Identification of residues that underpin interactions within the eukaryotic initiation factor (eIF2) 2B complexQ28730770
The mechanism of eukaryotic translation initiation and principles of its regulationQ29547270
Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeastQ29618547
Yeast transformation by the LiAc/SS Carrier DNA/PEG methodQ33222169
Crystal structure of potato tuber ADP-glucose pyrophosphorylaseQ33868406
Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.Q33890632
Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiationQ33969048
Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.Q34118639
The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivoQ34190226
eIF2B, a mediator of general and gene-specific translational controlQ34462402
Molecular mechanism of scanning and start codon selection in eukaryotesQ35192105
Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexesQ36555932
Purification of FLAG-tagged eukaryotic initiation factor 2B complexes, subcomplexes, and fragments from Saccharomyces cerevisiaeQ36965192
Clues to the mechanism of action of eIF2B, the guanine-nucleotide-exchange factor for translation initiationQ37217769
Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier.Q37629201
Protein synthesis and its control in neuronal cells with a focus on vanishing white matter diseaseQ37631649
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)8275-8285
P577publication date2012-01-11
P1433published inJournal of Biological ChemistryQ867727
P1476titleIdentification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation
P478volume287

Reverse relations

cites work (P2860)
Q38285158A new function and complexity for protein translation initiation factor eIF2B
Q28485114A yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM disease
Q38954159Crystal structure of eIF2B and insights into eIF2-eIF2B interactions
Q27704065Crystal structure of eukaryotic translation initiation factor 2B
Q28730770Identification of residues that underpin interactions within the eukaryotic initiation factor (eIF2) 2B complex
Q33710467Insights into the architecture of the eIF2Bα/β/δ regulatory subcomplex
Q36875727Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae
Q37138209Regulation of muscle protein synthesis and the effects of catabolic states
Q64986003Structural basis for the inhibition of translation through eIF2α phosphorylation.
Q28833240eIF2 interactions with initiator tRNA and eIF2B are regulated by post-translational modifications and conformational dynamics
Q27933768eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core
Q37424689eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation

Search more.