BRCA1 Forms a Functional Complex with γ-H2AX as a Late Response to Genotoxic Stress

scientific article published on 27 September 2010

BRCA1 Forms a Functional Complex with γ-H2AX as a Late Response to Genotoxic Stress is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4061/2010/801594
P932PMC publication ID2948912
P698PubMed publication ID20936109
P5875ResearchGate publication ID47385258

P50authorSusan A KrumQ55436935
P2093author name stringGustavo A Miranda-Carboni
Timothy F Lane
Esther de la Rosa Dalugdugan
P2860cites workMDC1 is a mediator of the mammalian DNA damage checkpointQ24296229
Identification of a RING protein that can interact in vivo with the BRCA1 gene productQ24324342
BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase IIQ24337878
A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining.Q53715599
BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected CellsQ60568779
Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chainsQ24543332
A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpointQ24558787
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structuresQ24606873
Megabase chromatin domains involved in DNA double-strand breaks in vivoQ24680284
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139Q28131715
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damageQ28144576
ATM phosphorylates histone H2AX in response to DNA double-strand breaksQ28188651
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stressQ28201846
BRCA1 Associates with Processive RNA Polymerase IIQ28204666
NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damageQ28205262
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutationQ28207617
Redistribution of BRCA1 among four different protein complexes following replication blockageQ28212699
Histone ubiquitination: a tagging tail unfolds?Q28218018
BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transitionQ28247388
BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent mannerQ28287385
Association of BRCA1 with Rad51 in mitotic and meiotic cellsQ28302118
Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closureQ28512661
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaksQ28609912
Brca1 controls homology-directed DNA repairQ29614844
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaksQ29617463
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damageQ29619360
Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.Q31983310
H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosisQ33965393
53BP1, a mediator of the DNA damage checkpointQ34153067
ATM and ataxia telangiectasiaQ34166198
DNA damage tumor suppressor genes and genomic instabilityQ35755997
BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome numberQ37515419
DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent mannerQ40315391
Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathwayQ40376906
BRCA1 required for transcription-coupled repair of oxidative DNA damageQ41016809
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.Q44378806
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectgenotoxicityQ1009245
P577publication date2010-09-27
P1433published inJournal of Nucleic AcidsQ26853953
P1476titleBRCA1 Forms a Functional Complex with γ-H2AX as a Late Response to Genotoxic Stress
P478volume2010

Reverse relations

cites work (P2860)
Q36016499A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion
Q38891869Central Role of Ubiquitination in Genome Maintenance: DNA Replication and Damage Repair
Q92128652Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers
Q38725261Novel splice-switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action.
Q35621531Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.
Q47102174Perturbation of PALB2 function by the T413S mutation found in small cell lung cancer
Q36003622Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response
Q38064172The role of BRCA1 in DNA double-strand repair: past and present

Search more.