Co-transcriptional degradation of aberrant pre-mRNA by Xrn2.

scientific article

Co-transcriptional degradation of aberrant pre-mRNA by Xrn2. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/EMBOJ.2012.101
P932PMC publication ID3365414
P698PubMed publication ID22522706
P5875ResearchGate publication ID224811229

P50authorAlastair KerrQ42182696
P2093author name stringLee Davidson
Steven West
P2860cites workThe in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicingQ21090175
A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional terminationQ24294892
Multiple mRNA Decapping Enzymes in Mammalian CellsQ24306739
Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sitesQ24317135
Functional analysis of mRNA scavenger decapping enzymesQ24540302
Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structuresQ24543188
Pause sites promote transcriptional termination of mammalian RNA polymerase IIQ24548945
The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosomeQ24644651
Efficient termination of transcription by RNA polymerase I requires the 5' exonuclease Rat1 in yeastQ24657729
The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription terminationQ24671920
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.Q40104313
Intergenic transcription and transinduction of the human beta-globin locusQ40442993
Synthesis of a gene for the HIV transactivator protein TAT by a novel single stranded approach involving in vivo gap repairQ40546117
The RNA processing exosome is linked to elongating RNA polymerase II in DrosophilaQ40682391
Inefficient processing impairs release of RNA from the site of transcriptionQ40954153
Deciphering the RNA polymerase II CTD code in fission yeastQ41876044
Gene-specific RNA polymerase II phosphorylation and the CTD codeQ42075763
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin AQ42146150
Crosstalk between mRNA 3' end processing and transcription initiationQ42821628
Processing of 3'-extended read-through transcripts by the exosome can generate functional mRNAs.Q44042962
Transcription. Seven ups the codeQ46850876
Cytoplasmic degradation of splice-defective pre-mRNAs and intermediatesQ47303263
The yeast 5'-3' exonuclease Rat1p functions during transcription elongation by RNA polymerase II.Q53339369
The Rat1p 5′ to 3′ Exonuclease Degrades Telomeric Repeat-Containing RNA and Promotes Telomere Elongation in Saccharomyces cerevisiaeQ63977010
Terminal exon definition occurs cotranscriptionally and promotes termination of RNA polymerase IIQ77308193
Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cellsQ80143464
Alternative isoform regulation in human tissue transcriptomesQ27861118
Endonucleolytic RNA cleavage by a eukaryotic exosomeQ27930673
Identification of a regulated pathway for nuclear pre-mRNA turnover.Q27931532
Quality control of mRNA 3'-end processing is linked to the nuclear exosomeQ27932977
Identification of a quality-control mechanism for mRNA 5'-end cappingQ27933732
Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional terminationQ27933929
The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II.Q27934493
A single subunit, Dis3, is essentially responsible for yeast exosome core activityQ27935552
Robust heat shock induces eIF2alpha-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae.Q27940310
Multiple transcript cleavage precedes polymerase release in termination by RNA polymerase IIQ28199201
The C-terminal domain of RNA polymerase II couples mRNA processing to transcriptionQ28301744
Exon tethering in transcription by RNA polymerase IIQ28302498
Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promotersQ28302903
U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylationQ29032058
Progression through the RNA polymerase II CTD cycleQ29614782
Pre-mRNA processing reaches back to transcription and ahead to translationQ29615045
Splice-site mutations cause Rrp6-mediated nuclear retention of the unspliced RNAs and transcriptional down-regulation of the splicing-defective genesQ33633977
RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes.Q34009055
Yeast Sen1 helicase protects the genome from transcription-associated instability.Q34157855
Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formationQ34246700
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factorsQ34419716
Comprehensive polyadenylation site maps in yeast and human reveal pervasive alternative polyadenylationQ34498318
5'-end surveillance by Xrn2 acts as a shared mechanism for mammalian pre-rRNA maturation and decayQ34699786
Primary microRNA transcripts are processed co-transcriptionally.Q34931030
Real-time imaging of cotranscriptional splicing reveals a kinetic model that reduces noise: implications for alternative splicing regulationQ35018262
Quality control of MATa1 splicing and exon skipping by nuclear RNA degradationQ35780104
A 5'----3' exoribonuclease of human placental nuclei: purification and substrate specificityQ36115044
Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional terminationQ36457126
Molecular dissection of mammalian RNA polymerase II transcriptional terminationQ36528493
Physical Isolation of Nascent RNA Chains Transcribed by RNA Polymerase II: Evidence for Cotranscriptional SplicingQ36669203
Transcriptional termination enhances protein expression in human cellsQ37251886
The exosome: a multipurpose RNA-decay machineQ37266936
The exosome associates cotranscriptionally with the nascent pre-mRNP through interactions with heterogeneous nuclear ribonucleoproteinsQ37285650
Coupled RNA processing and transcription of intergenic primary microRNAsQ37374749
Spliceosome assembly is coupled to RNA polymerase II dynamics at the 3' end of human genesQ39479568
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)2566-2578
P577publication date2012-04-20
P1433published inThe EMBO JournalQ1278554
P1476titleCo-transcriptional degradation of aberrant pre-mRNA by Xrn2.
P478volume31

Reverse relations

cites work (P2860)
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Q88634130Controlling nuclear RNA levels
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Q37499331Lessons from non-canonical splicing
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Q39983735Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing
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Q36956243Structural basis and function of XRN2 binding by XTB domains
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Q37343029Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp
Q100550292The eukaryotic translation initiation factor eIF4E elevates steady-state m7G capping of coding and noncoding transcripts
Q38122214The multifunctional RNase XRN2.
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Q98784946XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition
Q38725109hnRNPA1 autoregulates its own mRNA expression to remain non-cytotoxic
Q38164404mRNA quality control goes transcriptional.

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