| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/0006-2952(86)90527-7 |
| P698 | PubMed publication ID | 2867768 |
| P2093 | author name string | Anders MW | |
| Elfarra AA | |||
| Jakobson I | |||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 283-288 | |
| P577 | publication date | 1986-01-01 | |
| P1433 | published in | Biochemical Pharmacology | Q864229 |
| P1476 | title | Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity | |
| P478 | volume | 35 |
| Q47735443 | (1)H NMR spectroscopic studies on the characterization of renal cell lines and identification of novel potential markers of in vitro nephrotoxicity |
| Q51329952 | 2,4-Dichloro-1-nitrobenzene exerts carcinogenicities in both rats and mice by two years feeding. |
| Q89598952 | A Novel Assay Method to Determine the β-Elimination of Se-Methylselenocysteine to Monomethylselenol by Kynurenine Aminotransferase 1 |
| Q51587816 | Acid-labile adducts to protein can be used as indicators of the cysteine S-conjugate pathway of trichloroethene metabolism. |
| Q52237962 | Age- and Sex-Dependent Dichlorovinyl Cysteine (DCVC) Accumulation and Toxicity in the Mouse Kidney: Relation to Development of Organic Anion Transport and β-Lyase Activity |
| Q36467345 | Alcohol dehydrogenase- and rat liver cytosol-dependent bioactivation of 1-chloro-2-hydroxy-3-butene to 1-chloro-3-buten-2-one, a bifunctional alkylating agent |
| Q35961038 | Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene |
| Q38625462 | Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: formation of toxic and mutagenic intermediates by cysteine conjugate beta-lyase |
| Q42199231 | Biological monitoring of dichloropropene: air concentrations, urinary metabolite, and renal enzyme excretion |
| Q39645208 | Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites |
| Q41049463 | Biotransformation and membrane transport in nephrotoxicity |
| Q39665026 | Cellular effects of reactive intermediates: nephrotoxicity of S-conjugates of amino acids |
| Q40692210 | Cellular energetics and glutathione status in NRK-52E cells: toxicological implications. |
| Q36569475 | Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene |
| Q34421632 | Chemical-induced nephrotoxicity mediated by glutathione S-conjugate formation |
| Q42791128 | Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells |
| Q69444113 | Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney. VI. Specificity: amino acids, their N-methyl-, N-acetyl- and N-benzoylderivatives; glutathione- and cysteine conjugates, di- and oligopeptides |
| Q33477570 | Cysteine conjugate beta-lyase activity of rat erythrocytes and formation of beta-lyase-derived globin monoadducts and cross-links after in vitro exposure of erythrocytes to S-(1,2-dichlorovinyl)-L-cysteine |
| Q42211564 | Deacetylation and further metabolism of the mercapturic acid of hexachloro-1,3-butadiene by rat kidney cytosol in vitro |
| Q33916714 | Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment |
| Q69803366 | Dichlorovinyl cysteine (DCVC) in the mouse kidney: tissue-binding and toxicity after glutathione depletion and probenecid treatment |
| Q52569226 | Different effects of (CIS+TRANS) 1,3-dichloropropene in renal cortical slices derived from male and female rats. |
| Q51534164 | Dose-dependent binding of trichloroethylene to hepatic DNA and protein at low doses in mice. |
| Q72781491 | Effect of ascorbic acid, acivicin and probenecid on the nephrotoxicity of 4-aminophenol in the Fischer 344 rat |
| Q43603743 | Effects of 1,3-dichloropropene on the kidney of Fisher 344 rats after pretreatment with diethyl maleate, buthionine sulfoximine, and aminooxyacetic acid |
| Q45069650 | Effects of AT-125 on the nephrotoxicity of hexachloro-1,3-butadiene in rats |
| Q73137311 | Effects of probenecid on platelet aggregation and cytotoxicity: drawbacks of the use of probenecid in monitoring intracellular calcium metabolism |
| Q44425052 | Evidence for Trichloroethylene Bioactivation and Adduct Formation in the Rat Epididymis and Efferent Ducts1 |
| Q40693434 | Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate beta-lyase pathway |
| Q42506654 | Functional and toxicological characteristics of isolated renal mitochondria: impact of compensatory renal growth |
| Q37934204 | Glutamine transaminase K and cysteine conjugate beta-lyase |
| Q34024771 | Glutathione S-conjugates as prodrugs to target drug-resistant tumors |
| Q35956168 | Glutathione-dependent bioactivation of haloalkanes and haloalkenes |
| Q35533258 | Glutathione-dependent toxicity |
| Q43675630 | Immunochemical detection of covalently modified kidney proteins in S-(1,1,2,2,-tetrafluoroethyl)-L-cysteine-treated rats |
| Q28322617 | In vivo nephrotoxic action of an isomeric mixture of S-(1-phenyl-2-hydroxyethyl)glutathione and S(2-phenyl-2-hydroxyethyl)glutathione in Ficher-344 rats |
| Q38625465 | Influence of aging on chemically induced hepatotoxicity: role of age-related changes in metabolism |
| Q30308411 | Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice |
| Q28322893 | Inhibition of γ-glutamyl transpeptidase potentiates the nephrotoxicity of glutathione-conjugated chlorohydroquinones |
| Q36054933 | Interactive toxicity of inorganic mercury and trichloroethylene in rat and human proximal tubules: effects on apoptosis, necrosis, and glutathione status |
| Q37804266 | Is the toxicity of cysteine conjugates formed during mercapturic acid biosynthesis relevant to the toxicity of covalently bound drug residues? |
| Q35600652 | Metabolic activation and detoxication of nephrotoxic cysteine and homocysteine S-conjugates |
| Q36501510 | Metabolic interactions between drugs and renal tubulo-interstitial cells: Role in nephrotoxicity |
| Q34657985 | Metabolism and tissue distribution of orally administered trichloroethylene in male and female rats: identification of glutathione- and cytochrome P-450-derived metabolites in liver, kidney, blood, and urine |
| Q30310364 | Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells. |
| Q42221686 | Metabolism of S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine to hydrogen sulfide and the role of hydrogen sulfide in S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine-induced mitochondrial toxicity |
| Q42209952 | Metabolism of hexachloro-1,3-butadiene in mice: in vivo and in vitro evidence for activation by glutathione conjugation |
| Q33916680 | Metabolism of trichloroethylene |
| Q38687497 | Metabolism, toxicity, and carcinogenicity of trichloroethylene. |
| Q40437332 | Mitochondrial bioactivation of cysteine S-conjugates and 4-thiaalkanoates: Implications for mitochondrial dysfunction and mitochondrial diseases |
| Q28570943 | Mitochondrial stress protein recognition of inactivated dehydrogenases during mammalian cell death |
| Q33916696 | Modes of action of trichloroethylene for kidney tumorigenesis |
| Q46807655 | Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis |
| Q35990446 | Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione. |
| Q37328347 | Mouse aminoacylase 3: a metalloenzyme activated by cobalt and nickel |
| Q34685788 | Multigenerational study of chemically induced cytotoxicity and proliferation in cultures of human proximal tubular cells |
| Q50191098 | Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene. |
| Q36781326 | Mutagenicity of the cysteine S-conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test |
| Q45292557 | N(3,5-dichlorophenyl)succinimide nephrotoxicity: evidence against the formation of nephrotoxic glutathione or cysteine conjugates |
| Q38677036 | N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies? A critical evaluation of possibilities and limitations |
| Q42287675 | Nephrotoxicity and covalent binding of 1,1-dichloroethylene in buthionine sulphoximine-treated mice. |
| Q42281659 | Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors |
| Q24820786 | PULMONARY BIOACTIVATION OF TRICHLOROETHYLENE TO CHLORAL HYDRATE: RELATIVE CONTRIBUTIONS OF CYP2E1, CYP2F, AND CYP2B1 |
| Q35933401 | Protein kinase B/Akt modulates nephrotoxicant-induced necrosis in renal cells |
| Q42457967 | Protein kinase C-alpha inhibits the repair of oxidative phosphorylation after S-(1,2-dichlorovinyl)-L-cysteine injury in renal cells |
| Q38193747 | Regucalcin as a potential biomarker for metabolic and neuronal diseases |
| Q51587808 | Renal activation of trichloroethene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidneys of F344 rats and B6C3F1 mice. |
| Q73931682 | Renal cellular transport, metabolism, and cytotoxicity of S-(6-purinyl)glutathione, a prodrug of 6-mercaptopurine, and analogues |
| Q44400909 | Renal injury and repair following S-1, 2 dichlorovinyl-L-cysteine administration to mice |
| Q40647370 | Role of CysteineS-Conjugate β-Lyase in the Metabolism of Cisplatin |
| Q51420008 | Role of cytochrome P450 and glutathione S-transferase alpha in the metabolism and cytotoxicity of trichloroethylene in rat kidney. |
| Q24650646 | Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells |
| Q26849288 | Role of reactive metabolites in the circulation in extrahepatic toxicity |
| Q40517484 | Role of renal metabolism in risk to toxic chemicals |
| Q67654804 | Role of γ-glutamyltranspeptidase and β-lyase in the nephrotoxicity of hexachloro-1,3-butadiene and methyl mercury in mice |
| Q38024404 | Sex-related differences in renal toxicodynamics in rodents. |
| Q46060629 | Studies of the mechanism of nephrotoxicity of compound A in rats |
| Q58046413 | Studies on the comparative toxicity of S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-homocysteine and 1,1,2-trichloro-3,3,3-trifluoro-1-propene in the Fischer 344 rat |
| Q42281624 | Studies on the effects of L(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) on 4-aminophenol-induced nephrotoxicity in the Fischer 344 rat. |
| Q39540927 | Studies on the mechanism of nephrotoxicity and nephrocarcinogenicity of halogenated alkenes |
| Q42557171 | Suppressed expression of calcium-binding protein regucalcin mRNA in the renal cortex of rats with chemically induced kidney damage |
| Q34142825 | The transcriptional regulation of regucalcin gene expression |
| Q42730153 | The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene. |
| Q34776914 | Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism |
| Q68209512 | p-Aminophenol nephrotoxicity: Biosynthesis of toxic glutathione conjugates |
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