Renal activation of trichloroethene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidneys of F344 rats and B6C3F1 mice.

scientific article published in December 1995

Renal activation of trichloroethene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidneys of F344 rats and B6C3F1 mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/15287399509532049
P698PubMed publication ID8523472

P2093author name stringParker JC
Bull RJ
Stevens DK
Eyre RJ
P2860cites workMetabolism of trichloroethene--in vivo and in vitro evidence for activation by glutathione conjugation.Q51741878
Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats.Q51805205
Inhalation carcinogenicity of trichloroethylene in mice and rats.Q51856847
Carcinogenicity study of trichloroethylene by longterm inhalation in three animal species.Q51877624
Age- and Sex-Dependent Dichlorovinyl Cysteine (DCVC) Accumulation and Toxicity in the Mouse Kidney: Relation to Development of Organic Anion Transport and β-Lyase ActivityQ52237962
Metabolic activation and detoxication of nephrotoxic cysteine and homocysteine S-conjugatesQ35600652
Peroxidative damage and nephrotoxicity of dichlorovinylcysteine in miceQ36085932
The role of damage and proliferation in renal carcinogenesisQ37970715
Cysteine conjugate beta-lyase of rat kidney cytosol: characterization, immunocytochemical localization, and correlation with hexachlorobutadiene nephrotoxicityQ41949313
Measurement of chemically induced cell proliferation in rodent liver and kidney: a comparison of 5-bromo-2'-deoxyuridine and [3H]thymidine administered by injection or osmotic pumpQ42094599
Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicityQ42201459
Mutagenicity of amino acid and glutathione S-conjugates in the Ames testQ42202583
Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene.Q50191098
Acid-labile adducts to protein can be used as indicators of the cysteine S-conjugate pathway of trichloroethene metabolism.Q51587816
Identification of N-acetyl(2,2-dichlorovinyl)- and N-acetyl(1,2-dichlorovinyl)-L-cysteine as two regioisomeric mercapturic acids of trichloroethylene in the rat.Q51736177
P433issue4
P921main subjectL-CysteineQ186474
P304page(s)465-481
P577publication date1995-12-01
P1433published inJournal of Toxicology and Environmental HealthQ16749713
P1476titleRenal activation of trichloroethene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidneys of F344 rats and B6C3F1 mice.
P478volume46

Reverse relations

cites work (P2860)
Q51587816Acid-labile adducts to protein can be used as indicators of the cysteine S-conjugate pathway of trichloroethene metabolism.
Q35961038Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene
Q31440429Cytotoxicity of trichloroethylene and S-(1, 2-dichlorovinyl)-L-cysteine in primary cultures of rat renal proximal tubular and distal tubular cells
Q33916714Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment
Q51505954Formic acid excretion in rats exposed to trichloroethylene: a possible explanation for renal toxicity in long-term studies.
Q26801059Genotoxicity of Anesthetics Evaluated In Vivo (Animals)
Q44579065Increased formic acid excretion and the development of kidney toxicity in rats following chronic dosing with trichloroethanol, a major metabolite of trichloroethylene
Q51519805Increased frequency of micronucleated kidney cells in rats exposed to halogenated anaesthetics.
Q33916680Metabolism of trichloroethylene
Q33916696Modes of action of trichloroethylene for kidney tumorigenesis
Q51538850The role of glutathione conjugation in the development of kidney tumours in rats exposed to trichloroethylene.
Q30596382Trichloroethylene induced vitamin B(12) and folate deficiency leads to increased formic acid excretion in the rat.

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