Selective recognition of a DNA G-quadruplex by an engineered antibody

scientific article published on 15 August 2008

Selective recognition of a DNA G-quadruplex by an engineered antibody is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/BI800983U
P932PMC publication ID2746966
P698PubMed publication ID18702511
P5875ResearchGate publication ID23170244

P50authorRaphaël RodriguezQ39486109
P2093author name stringShankar Balasubramanian
Himesh Fernando
P2860cites workCrystal structure of parallel quadruplexes from human telomeric DNAQ22122125
Highly prevalent putative quadruplex sequence motifs in human DNAQ24529050
Prevalence of quadruplexes in the human genomeQ24529051
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcriptionQ24535577
Structure of the first parallel DNA quadruplex-drug complexQ27640870
Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit PromoterQ27644075
Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplexQ27730906
The yeast telomere-binding protein RAP1 binds to and promotes the formation of DNA quadruplexes in telomeric DNA.Q27933905
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronucleiQ28204801
Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivoQ28270626
Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surfaceQ29616401
Inhibition of telomerase by G-quartet DNA structuresQ30450395
Use of phage display and high-density screening for the isolation of an antibody against the 51-kDa subunit of complex I.Q30903479
Antibody arrays for high-throughput screening of antibody-antigen interactionsQ30918339
Selection of zinc fingers that bind single-stranded telomeric DNA in the G-quadruplex conformationQ30979040
Generation and characterization of a novel single-chain antibody fragment specific against human fibrin clots from phage display antibody libraryQ31108675
Detection and quantification of microcystins (cyanobacterial hepatotoxins) with recombinant antibody fragments isolated from a naïve human phage display library.Q31832223
Following G-quartet formation by UV-spectroscopyQ32012738
Identification of single-chain antibody fragments specific against SARS-associated coronavirus from phage-displayed antibody libraryQ33212372
A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexesQ33311334
Human autoantibody recognition of DNAQ34475971
Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solutionQ34623697
Tetraplex DNA and its interacting proteinsQ36813999
An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solutionQ36914814
A hitchhiker's guide to G-quadruplex ligandsQ37080928
Polymorphism of human telomeric quadruplex structuresQ37122034
Thermodynamics and structure of a DNA tetraplex: a spectroscopic and calorimetric study of the tetramolecular complexes of d(TG3T) and d(TG3T2G3T)Q37210778
Sequencing and modeling of anti-DNA immunoglobulin Fv domains. Comparison with crystal structures.Q38311297
Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry.Q38784060
Molecular analysis of anti-DNA antibodiesQ40387456
Chromatin specificity of anti-double-stranded DNA antibodies and a role for Arg residues in the third complementarity-determining region of the heavy chainQ40614051
Putative DNA quadruplex formation within the human c-kit oncogeneQ41774419
Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoterQ41809692
Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognitionQ41842359
Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligandsQ41866664
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogeneQ42108961
Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expressionQ42947453
Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger proteinQ42947825
C-kit gene abnormalities in gastrointestinal stromal tumors (tumors of interstitial cells of CajalQ43848730
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplexQ43905645
Loop-length-dependent folding of G-quadruplexesQ45188262
Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilizationQ45255075
Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairsQ46058606
Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodiesQ48060139
G-Quadruplex-Specific Peptide−Hemicyanine Ligands by Partial Combinatorial SelectionQ57057823
The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4Q80334969
P433issue36
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)9365-9371
P577publication date2008-08-15
P1433published inBiochemistryQ764876
P1476titleSelective recognition of a DNA G-quadruplex by an engineered antibody
P478volume47

Reverse relations

cites work (P2860)
Q33381789A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres
Q34413414Advances in the molecular design of potential anticancer agents via targeting of human telomeric DNA.
Q38290440Altered biochemical specificity of G-quadruplexes with mutated tetrads
Q52721879Autoantibody Profiling in Lupus Patients using Synthetic Nucleic Acids.
Q30356394Combining Yeast Display and Competitive FACS to Select Rare Hapten-Specific Clones from Recombinant Antibody Libraries
Q34486584DNA and RNA quadruplex-binding proteins
Q35562505Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex
Q64102392G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
Q41847291G-quadruplex structures are stable and detectable in human genomic DNA.
Q34044280G-quadruplexes are specifically recognized and distinguished by selected designed ankyrin repeat proteins
Q38154988G-quadruplexes as potential therapeutic targets for embryonal tumors
Q34489819G-quadruplexes in viruses: function and potential therapeutic applications
Q39800990Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression
Q50608768Implication of the solvent effect, metal ions and topology in the electronic structure and hydrogen bonding of human telomeric G-quadruplex DNA.
Q33645110Loop and backbone modifications of peptide nucleic acid improve g-quadruplex binding selectivity
Q37857036Nucleic acid based molecular devices
Q87918916Potential Roles for G-Quadruplexes in Mitochondria
Q89644393Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons
Q37377116Strand invasion of DNA quadruplexes by PNA: comparison of homologous and complementary hybridization.
Q33915919Structural insights into G-quadruplexes: towards new anticancer drugs
Q38928964Structure, Properties, and Biological Relevance of the DNA and RNA G-Quadruplexes: Overview 50 Years after Their Discovery.
Q35620887The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme
Q37872840The evolving world of protein-G-quadruplex recognition: a medicinal chemist's perspective.
Q52735441The interplay between G-quadruplex and Transcription.
Q35126113The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements
Q33558251U3 region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence
Q42720429Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells.

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