Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages

scientific article published on February 1993

Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ2900165
P932PMC publication ID1132397
P698PubMed publication ID8439285
P5875ResearchGate publication ID14760595

P2093author name stringStocker R
Hazell LJ
P2860cites workMyeloperoxidase, hydrogen peroxide, chloride antimicrobial system: nitrogen-chlorine derivatives of bacterial components in bactericidal action against Escherichia coliQ24564090
Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherolQ24564131
Determination of fatty acids in the main lipoprotein classes by capillary gas chromatography: BF3/methanol transesterification of lyophilized samples instead of folch extraction gives higher yieldsQ67906714
On the action of hypochlorite on human serum albuminQ68077521
Modification of human low-density lipoprotein by the lipid peroxidation product 4-hydroxynonenalQ68857189
Detection and characterization of lipid hydroperoxides at picomole levels by high-performance liquid chromatographyQ68980840
Single vertical spin density gradient ultracentrifugationQ69553503
Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptorQ69635952
Peroxidation of phospholipids promoted by myeloperoxidaseQ69849607
Copper ions and hydrogen peroxide form hypochlorite from NaCl thereby mimicking myeloperoxidaseQ70137938
Chlorination of endogenous amines by isolated neutrophils. Ammonia-dependent bactericidal, cytotoxic, and cytolytic activities of the chloraminesQ70375073
Long-lived oxidants generated by human neutrophils: characterization and bioactivityQ71084427
Fine structure of human aortic intimal thickening and fatty streaksQ72587977
Measurement of protein using bicinchoninic acidQ26778491
Studies on the chlorinating activity of myeloperoxidaseQ28235493
Reassessment of Ellman's reagentQ28274979
The complete cDNA and amino acid sequence of human apolipoprotein B-100Q28304252
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol depositionQ28625661
Role of lysines in mediating interaction of modified low density lipoproteins with the scavenger receptor of human monocyte macrophagesQ28678300
A receptor-mediated pathway for cholesterol homeostasisQ29616158
Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicityQ29617216
Antioxidant defenses and lipid peroxidation in human blood plasmaQ33688237
Isolation and characterization of sulfhydryl and disulfide peptides of human apolipoprotein B-100.Q33700536
Phagocytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor-dependent foam-cell formationQ33850346
Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of the oxidant to hypochloriteQ34048534
Chlorohydrin formation from unsaturated fatty acids reacted with hypochlorous acidQ34236440
Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cellsQ34526444
Stimulation of mast cells leads to cholesterol accumulation in macrophages in vitro by a mast cell granule-mediated uptake of low density lipoproteinQ34613071
Generation of nitrogen-chlorine oxidants by human phagocytesQ34617174
Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in cultureQ34620804
Oxidative damage to fibronectin. I. The effects of the neutrophil myeloperoxidase system and HOClQ34777504
Arterial foam cells with distinctive immunomorphologic and histochemical features of macrophagesQ35863970
Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipidsQ36263522
Oxidation of methionine residues in proteins of activated human neutrophilsQ37508674
The Low-Density Lipoprotein Pathway and its Relation to AtherosclerosisQ37605132
Role of oxidatively modified LDL in atherosclerosisQ37978587
Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteinsQ40099596
N-(2-Oxoacyl)amino Acids and Nitriles as Final Products of Dipeptide Chlorination Mediated by the Myeloperoxidase/H2O2/Cl- SystemQ40197363
The ultraviolet fluorescence of proteins in neutral solutionQ41773649
Recognition of oxidized low density lipoprotein by the scavenger receptor of macrophages results from derivatization of apolipoprotein B by products of fatty acid peroxidation.Q41874485
The antioxidant action of human extracellular fluids. Effect of human serum and its protein components on the inactivation of alpha 1-antiproteinase by hypochlorous acid and by hydrogen peroxideQ42011048
The oxidative modification of low-density lipoproteins by macrophagesQ42795258
5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoproteinQ42862580
Brominating oxidants generated by human eosinophilsQ43746020
Platelet-modified low density lipoprotein induces macrophage cholesterol accumulation and platelet activationQ43858088
Modifications of low-density lipoprotein induced by arterial proteoglycans and chondroitin-6-sulfateQ44014273
A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein.Q45945242
Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modificationQ46508007
Fluorometric assay of proteins in the nanogram rangeQ47965597
Simultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions.Q53887257
The chloroperoxidase-catalyzed oxidation of thiols and disulfides to sulfenyl chlorides.Q54254114
Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by ascorbic acidQ61824681
The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoproteinQ67504070
Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidationQ67822470
Sulfhydryl-selective fluorescence labeling of lipoprotein(a) reveals evidence for one single disulfide linkage between apoproteins(a) and B-100Q67904697
P407language of work or nameEnglishQ1860
P921main subjectlipoproteinQ28350
macrophageQ184204
P304page(s)165-172
P577publication date1993-02-01
P1433published inBiochemical JournalQ864221
P1476titleOxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages
P478volume290 ( Pt 1)

Reverse relations

cites work (P2860)
Q373662883-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima
Q42679591A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages
Q33693133A role for reduced coenzyme Q in atherosclerosis?
Q43777189Actin carbonylation: from a simple marker of protein oxidation to relevant signs of severe functional impairment.
Q73762580Alpha-tocopherol does not inhibit hypochlorite-induced oxidation of apolipoprotein B-100 of low-density lipoprotein
Q36297106Alpha-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids
Q41449076Apolipoprotein oxidation in the absence of lipid peroxidation enhances LDL uptake by macrophages
Q40637436Apoptotic pathways involved in U937 cells exposed to LDL oxidized by hypochlorous acid
Q37364334Association of serum myeloperoxidase with the ankle-brachial index and peripheral arterial disease
Q37172222Association of serum osteoprotegerin with ankle-brachial index and urine albumin: creatinine ratio in African-Americans and non-Hispanic whites
Q73072515Beta-blockers inhibit the modification of low-density lipoproteins by sodium hypochlorite in vitro
Q41481967Biochemistry and pathology of radical-mediated protein oxidation
Q42338456Boosting endogenous production of vasoprotective hydrogen sulfide via supplementation with taurine and N-acetylcysteine: a novel way to promote cardiovascular health
Q43685736Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups
Q42028055Characterization of non-covalent oligomers of proteins treated with hypochlorous acid
Q59807449Chlorination and oxidation of the extracellular matrix protein laminin and basement membrane extracts by hypochlorous acid and myeloperoxidase
Q44020614Comparative time-courses of copper-ion-mediated protein and lipid oxidation in low-density lipoprotein
Q43989150Comparison of two methods for radioiodination on the oxidizability properties of low density lipoprotein
Q34397148Contributions of myeloperoxidase to proinflammatory events: more than an antimicrobial system
Q46812978Copper- and magnesium protoporphyrin complexes inhibit oxidative modification of LDL induced by hemin, transition metal ions and tyrosyl radicals.
Q77161290Correlation between intima-to-media ratio, apolipoprotein B-100, myeloperoxidase, and hypochlorite-oxidized proteins in human atherosclerosis
Q35747306Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis
Q34758389Distinct HDL subclasses present similar intrinsic susceptibility to oxidation by HOCl.
Q43964246Effect of acetaminophen on the myeloperoxidase-hydrogen peroxide-nitrite mediated oxidation of LDL.
Q28344995Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino-acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions and advanced atherosclerotic lesions
Q41565256Endogenous and exogenous antioxidants and the generation of antigenic epitopes in oxidatively-modified LDL.
Q28360674Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL
Q38455185Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs
Q44219160Homocysteine promotes the LDL oxidase activity of ceruloplasmin
Q43650867Human neutrophils employ the myeloperoxidase/hydrogen peroxide/chloride system to oxidatively damage apolipoprotein A-I.
Q35764845Human suction blister interstitial fluid prevents metal ion-dependent oxidation of low density lipoprotein by macrophages and in cell-free systems
Q40945169Hypochlorite modification of high density lipoprotein: effects on cholesterol efflux from J774 macrophages
Q73103541Hypochlorite modified LDL are a stronger agonist for platelets than copper oxidized LDL
Q41952132Hypochlorite-induced damage to proteins: formation of nitrogen-centred radicals from lysine residues and their role in protein fragmentation
Q43559341Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase
Q42252354Hypochlorite-modified low-density lipoprotein induces the apoptotic machinery in Jurkat T-cell lines
Q74445963Hypochlorite-modified low-density lipoprotein stimulates human polymorphonuclear leukocytes for enhanced production of reactive oxygen metabolites, enzyme secretion, and adhesion to endothelial cells
Q40379637Hypochlorite-oxidized low-density lipoprotein upregulates CD36 and PPARgamma mRNA expression and modulates SR-BI gene expression in murine macrophages
Q41289645Hypochlorous acid and its pharmacological antagonism: an update picture
Q37406247Hypochlorous acid-induced heme oxygenase-1 gene expression promotes human endothelial cell survival
Q43897071Hypochlorous acid-modified low-density lipoprotein inactivates the lysosomal protease cathepsin B: protection by ascorbic and lipoic acids
Q71431257Hypocholesterolemic and immunostimulatory effects of orally applied Enterococcus faecium M-74 in man
Q35764605Immunological evidence for hypochlorite-modified proteins in human kidney
Q37665476Impact of myeloperoxidase-LDL interactions on enzyme activity and subsequent posttranslational oxidative modifications of apoB-100.
Q28350068Increased atherosclerosis in myeloperoxidase-deficient mice
Q37705110Inflammation-associated S100 proteins: new mechanisms that regulate function.
Q35098331Influence of native and hypochlorite-modified low-density lipoprotein on gene expression in human proximal tubular epithelium
Q41574079Inhibition of LDL oxidation by ubiquinol-10. A protective mechanism for coenzyme Q in atherogenesis?
Q33759336Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides
Q73923990Kinetics of tryptophan oxidation in plasma lipoproteins by myeloperoxidase-generated HOCl
Q43943413Low density lipoprotein of synovial fluid in inflammatory joint disease is mildly oxidized.
Q41615081Low-density lipoprotein and oxidised low-density lipoprotein: their role in the development of atherosclerosis
Q37091275Low-density lipoprotein modified by myeloperoxidase in inflammatory pathways and clinical studies.
Q98726639MicroRNA sequences modulating inflammation and lipid accumulation in macrophage "foam" cells: Implications for atherosclerosis
Q36551322Modified low-density lipoproteins and high-density lipoproteins. From investigation tools to real in vivo players
Q34006317Molecular action of vitamin E in lipoprotein oxidation: implications for atherosclerosis
Q55426892Myeloperoxidase as an Active Disease Biomarker: Recent Biochemical and Pathological Perspectives.
Q73378050Myeloperoxidase binds to low-density lipoprotein: potential implications for atherosclerosis
Q44733343Myeloperoxidase gene variation and coronary flow reserve in young healthy men.
Q46834806Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: a potential pathway for somatic mutagenesis by macrophages
Q64077636Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition
Q34236265Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions
Q34006268Myeloperoxidase-generated oxidants and atherosclerosis
Q33852491Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro
Q46279450Not All Inner Ears are the Same: Otolith Matrix Proteins in the Inner Ear of Sub-Adult Cichlid Fish, Oreochromis Mossambicus, Reveal Insights Into the Biomineralization Process
Q73110368Oxidation of heparin-treated low density lipoprotein by peroxidases
Q24528264Oxidation of low-density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidation
Q37806960Oxidative mechanisms and atherothrombotic cardiovascular disease
Q73370736Oxidative modifications of apoB-100 by exposure of low density lipoproteins to HOCL in vitro
Q33554184Oxidative risk for atherothrombotic cardiovascular disease
Q34658022Oxidized amino acids: culprits in human atherosclerosis and indicators of oxidative stress
Q77910747Oxysterols and atherosclerosis
Q40343992Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases
Q48300156Paradoxical effects of SAA on lipoprotein oxidation suggest a new antioxidant function for SAA.
Q41528108Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor
Q34405070Plant-derived phenolics inhibit the accrual of structurally characterised protein and lipid oxidative modifications
Q44247254Plasma phospholipid transfer protein-mediated reactions are impaired by hypochlorite-modification of high density lipoprotein
Q42550801Plasma ubiquinol-10 is decreased in patients with hyperlipidaemia
Q37353371Presence of hypochlorite-modified proteins in human atherosclerotic lesions
Q74450852Protective effects of carnosine against protein modification mediated by malondialdehyde and hypochlorite
Q27021668Protein Oxidation in Aging: Does It Play a Role in Aging Progression?
Q34119149Quantification and significance of protein oxidation in biological samples
Q28375883Reactions of hypochlorous acid with tyrosine and peptidyl-tyrosyl residues give dichlorinated and aldehydic products in addition to 3-chlorotyrosine
Q42995934Reagent or myeloperoxidase-generated hypochlorite affects discrete regions in lipid-free and lipid-associated human apolipoprotein A-I.
Q64887718Receptors for oxidized low density lipoprotein.
Q37446110Redox signaling in cardiovascular health and disease.
Q46468624Reducing oxidized lipids to prevent cardiovascular disease
Q41819702Reduction of the surface-tension-lowering ability of surfactant after exposure to hypochlorous acid
Q54034451Relative reactivity of lysine and other peptide-bound amino acids to oxidation by hypochlorite.
Q41051532Review of progress in sterol oxidations: 1987-1995.
Q61978284Salicylate inhibits LDL oxidation initiated by superoxide/nitric oxide radicals
Q61978281Salicylate promotes myeloperoxidase-initiated LDL oxidation: antagonization by its metabolite gentisic acid
Q41937076Secondary radicals derived from chloramines of apolipoprotein B-100 contribute to HOCl-induced lipid peroxidation of low-density lipoproteins
Q40126438Soluble RAGE blocks scavenger receptor CD36-mediated uptake of hypochlorite-modified low-density lipoprotein
Q37809431Taurine in cardiovascular disease
Q24682551The aryl hydrocarbon receptor is activated by modified low-density lipoprotein
Q59033590The effect of reagents mimicking oxidative stress on fibrinogen function
Q37433102The impact of rapid weight loss on oxidative stress markers and the expression of the metabolic syndrome in obese individuals.
Q41628567The interplay of nitric oxide and peroxynitrite with signal transduction pathways: implications for disease
Q41565280The mechanism of the hypochlorite-induced lipid peroxidation
Q44804722The protective effects of HDL and its constituents against neutrophil respiratory burst activation by hypochlorite-oxidized LDL.
Q30240734The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture.
Q36386406Tripping up Trp: Modification of protein tryptophan residues by reactive oxygen species, modes of detection, and biological consequences
Q61978290Tyrosine: an inhibitor of LDL oxidation and endothelial cell cytotoxicity initiated by superoxide/nitric oxide radicals 1
Q34787028Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammation
Q73853371Urate attenuates oxidation of native low-density lipoprotein by hypochlorite and the subsequent lipoprotein-induced respiratory burst activities of polymorphonuclear leukocytes
Q36636155VPO1 mediates ApoE oxidation and impairs the clearance of plasma lipids
Q41998801Vitamin C protects against and reverses specific hypochlorous acid- and chloramine-dependent modifications of low-density lipoprotein
Q41769762When and why a water-soluble antioxidant becomes pro-oxidant during copper-induced low-density lipoprotein oxidation: a study using uric acid
Q31924329p-Hydroxyphenylacetaldehyde, the major product of tyrosine oxidation by the activated myeloperoxidase system can act as an antioxidant in LDL.

Search more.