Roles of SGS1, MUS81, and RAD51 in the repair of lagging-strand replication defects in Saccharomyces cerevisiae

scientific article published on October 2005

Roles of SGS1, MUS81, and RAD51 in the repair of lagging-strand replication defects in Saccharomyces cerevisiae is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1009192628
P356DOI10.1007/S00294-005-0014-5
P932PMC publication ID1828632
P698PubMed publication ID16193328
P5875ResearchGate publication ID7572194

P2093author name stringMiki Ii
Steven J Brill
P2860cites workMutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndromeQ22009558
Identification and characterization of human MUS81-MMS4 structure-specific endonucleaseQ24299599
The Bloom's syndrome gene product is homologous to RecQ helicasesQ24313440
Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseasesQ24317166
Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiaeQ24533200
Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiaeQ24548169
Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiaeQ24548535
Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replicationQ27630668
RNase H2 of Saccharomyces cerevisiae is a complex of three proteinsQ27930321
Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nucleaseQ27930354
Dna2 mutants reveal interactions with Dna polymerase alpha and Ctf4, a Pol alpha accessory factor, and show that full Dna2 helicase activity is not essential for growthQ27930620
The absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate: implications for roles of RNases H in DNA replication and repairQ27931541
Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae.Q27931991
A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Q27932204
Accelerated aging and nucleolar fragmentation in yeast sgs1 mutantsQ27933022
Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damageQ27933291
RPA regulates telomerase action by providing Est1p access to chromosome endsQ27933681
SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombinationQ27935480
Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonucleaseQ27935913
Mcm1 regulates donor preference controlled by the recombination enhancer in Saccharomyces mating-type switchingQ27936567
MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiaeQ27939646
Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregationQ27939683
5-Fluoroorotic acid as a selective agent in yeast molecular geneticsQ28131614
Elevated recombination rates in transcriptionally active DNAQ28131616
Systematic genetic analysis with ordered arrays of yeast deletion mutantsQ28131618
The Bloom's syndrome gene product interacts with topoisomerase IIIQ28139703
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyraseQ28170377
Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51Q28207894
Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null miceQ28592636
Regulation of telomerase by telomeric proteinsQ29616133
RecQ helicases: caretakers of the genomeQ29618390
Positional cloning of the Werner's syndrome geneQ29618393
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeastQ29618612
Mus81-Eme1 are essential components of a Holliday junction resolvaseQ29619843
RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotesQ30704734
Isolation and characterization of a second RNase H (RNase HII) of Escherichia coli K-12 encoded by the rnhB geneQ31022160
The protein components and mechanism of eukaryotic Okazaki fragment maturationQ31034204
Involvement of SGS1 in DNA damage-induced heteroallelic recombination that requires RAD52 in Saccharomyces cerevisiaeQ32048153
DNA topoisomerase-targeting antitumor drugs can be studied in yeastQ33654182
Defending genome integrity during DNA replication: a proposed role for RecQ family helicasesQ33666386
Mutational spectrum analysis of RNase H(35) deficient Saccharomyces cerevisiae using fluorescence-based directed termination PCR.Q33786781
The essential role of yeast topoisomerase III in meiosis depends on recombinationQ33890637
The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH geneQ33957478
Use of a chromosomal inverted repeat to demonstrate that the RAD51 and RAD52 genes of Saccharomyces cerevisiae have different roles in mitotic recombinationQ33963818
Identification and characterization of the human mus81-eme1 endonucleaseQ34193657
Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extractsQ34429499
Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replicationQ34430247
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damageQ34430366
Identification of the genes encoding Mn2+-dependent RNase HII and Mg2+-dependent RNase HIII from Bacillus subtilis: classification of RNases H into three familiesQ34487534
A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombeQ34575480
Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiaeQ34608894
Disruption of theCrithidia fasciculata RNH1gene results in the loss of two active forms of ribonuclease HQ34761035
The Mechanism of Mus81-Mms4 Cleavage Site Selection Distinguishes It from the Homologous Endonuclease Rad1-Rad10Q35148358
Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiaeQ36701282
The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genesQ39682063
Homologous recombination is required for the viability of rad27 mutantsQ39726024
Role for the fission yeast RecQ helicase in DNA repair in G2.Q39787542
Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage toleranceQ40023980
DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51.Q40249048
The involvement of Srs2 in post-replication repair and homologous recombination in fission yeastQ40773146
A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomeraseQ42641816
SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiaeQ42967143
DNA helicase gene interaction network defined using synthetic lethality analyzed by microarrayQ43446083
Inactivation of homologous recombination suppresses defects in topoisomerase III-deficient mutantsQ44267600
Budding yeast mms4 is epistatic with rad52 and the function of Mms4 can be replaced by a bacterial Holliday junction resolvaseQ44290859
The ability of Sgs1 to interact with DNA topoisomerase III is essential for damage-induced recombinationQ45182071
Drosophila RNase H1 is essential for development but not for proliferationQ46138782
Cleavage of model replication forks by fission yeast Mus81-Eme1 and budding yeast Mus81-Mms4.Q53661726
Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicasesQ73844491
Functional domains required for the Saccharomyces cerevisiae Mus81-Mms4 endonuclease complex formation and nuclear localizationQ79328396
P433issue4
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)213-225
P577publication date2005-10-01
P1433published inCurrent GeneticsQ15765847
P1476titleRoles of SGS1, MUS81, and RAD51 in the repair of lagging-strand replication defects in Saccharomyces cerevisiae
P478volume48

Reverse relations

cites work (P2860)
Q42108506A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication.
Q37149779A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4.
Q37713613A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability
Q27933571An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks
Q24652448Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex
Q35182121Epistasis analysis between homologous recombination genes in Saccharomyces cerevisiae identifies multiple repair pathways for Sgs1, Mus81-Mms4 and RNase H2
Q36990200Flexibility of eukaryotic Okazaki fragment maturation through regulated strand displacement synthesis
Q34368094Genetic and functional interactions between Mus81-Mms4 and Rad27.
Q34895210Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans
Q37472978Incision of damaged DNA in the presence of an impaired Smc5/6 complex imperils genome stability
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Q33369076MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis
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Q28469182Multiple-pathway analysis of double-strand break repair mutations in Drosophila
Q34492648Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast
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Q34025948Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes
Q35683347RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA
Q37507641Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation
Q40540204Roles of DNA helicases in the mediation and regulation of homologous recombination
Q89093963Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling
Q33594452Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome ends
Q35130760Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants
Q33698561The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage
Q58730668The topoisomerase 3α zinc-finger domain T1 of Arabidopsis thaliana is required for targeting the enzyme activity to Holliday junction-like DNA repair intermediates