Abnormal cell responses and role of TNF-α in impaired diabetic wound healing

scientific article published on 20 January 2013

Abnormal cell responses and role of TNF-α in impaired diabetic wound healing is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1155/2013/754802
P932PMC publication ID3581278
P698PubMed publication ID23484152
P5875ResearchGate publication ID236040459

P50authorFanxing XuQ60319797
P2093author name stringDana T Graves
Chenying Zhang
P2860cites workBone marrow-derived mesenchymal stem cells enhanced diabetic wound healing through recruitment of tissue regeneration in a rat model of streptozotocin-induced diabetes.Q53219175
Differential roles of macrophages in diverse phases of skin repair.Q54440277
Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 DiabetesQ57790499
CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnoverQ61937663
Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healingQ71070277
Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skinQ73081960
High-dose proinflammatory cytokines induce apoptosis of hair bulb keratinocytes in vivoQ73167346
CD34+ blood cells accelerate vascularization and healing of diabetic mouse skin woundsQ73734481
Expression of apoptosis- and cell cycle-related proteins in epidermis of venous leg and diabetic foot ulcersQ73881918
Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repairQ74199089
Levels of tumor necrosis factor-alpha (TNF-alpha) and soluble TNF receptors in chronic venous leg ulcers--correlations to healing statusQ74323419
Autologous biograft and mesenchymal stem cells in treatment of the diabetic footQ79423356
Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytesQ80371504
Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1Q80535789
Hypoxia-inducible factor-1α is essential for hypoxia-induced mesenchymal stem cell mobilization into the peripheral bloodQ83319024
A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelAQ24610268
Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptorQ24683742
High glucose-mediated oxidative stress impairs cell migrationQ27329542
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin ResistanceQ28131660
Impaired gastric ulcer healing in diabetic rats: role of heat shock protein, growth factors, prostaglandins and proinflammatory cytokinesQ28166285
Lifetime Risk for Diabetes Mellitus in the United StatesQ28207985
The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over timeQ28285897
Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and functionQ28505705
Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotypeQ28507352
Regulation of wound healing by growth factors and cytokinesQ29615242
Macrophage activation and polarizationQ29616353
Wound healing--aiming for perfect skin regenerationQ29616715
Wound repair and regenerationQ29617949
Cutaneous wound healingQ29618894
Elevated glucose and diabetes promote interleukin-12 cytokine gene expression in mouse macrophagesQ30439419
Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healingQ33326623
Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic miceQ33537990
The phenotype of murine wound macrophagesQ33571172
Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis.Q50674319
The biology of chronic foot ulcers in persons with diabetesQ37149378
Macrophage polarization in bacterial infectionsQ37259940
CXC chemokines and their receptors: a case for a significant biological role in cutaneous wound healingQ37266327
The pro-inflammatory environment in recalcitrant diabetic foot woundsQ37324588
Mesenchymal stem cells and skin wound repair and regeneration: possibilities and questionsQ37335119
High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healingQ37362094
Growth factors and cytokines in wound healingQ37364066
The receptor for advanced glycation endproducts (RAGE) and cardiovascular diseaseQ37412673
Exploring the role of stem cells in cutaneous wound healingQ37589735
Mesenchymal Stem Cells: Mechanisms of InflammationQ37809081
Macrophages in skin injury and repairQ37833809
Macrophage polarization and bacterial infectionsQ37839626
Transforming Growth Factor-β and Endoglin Signaling Orchestrate Wound HealingQ37967810
Epithelial stem cells, wound healing and cancerQ37987841
Wound repair and regenerationQ38026474
TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP.Q39407549
Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetesQ39488787
FOXO1 plays an essential role in apoptosis of retinal pericytesQ39626888
Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanismsQ40685684
Physiology of the chronic wound.Q40847280
Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblastsQ40901783
Tumor necrosis factor alpha regulates proliferation in a mouse intestinal cell lineQ41119457
Impaired wound healing in mouse models of diabetes is mediated by TNF-alpha dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1).Q41776430
Blockade of receptor for advanced glycation end-products restores effective wound healing in diabetic mice.Q41893958
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularizationQ42130997
Differential regulation of pro-inflammatory cytokines during wound healing in normal and glucocorticoid-treated miceQ42526145
IL-1 plays a critical role in oral, but not dermal, wound healingQ42662179
Relationship between apoptotic markers (Bax and Bcl-2) and biochemical markers in type 2 diabetes mellitus.Q43143576
Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stressQ43649151
Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcersQ44024457
Tumor necrosis factor-α inhibits transforming growth factor-β-stimulated myofibroblastic differentiation and extracellular matrix production in human gingival fibroblastsQ44104858
Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice.Q44457827
Adverse effects of dietary glycotoxins on wound healing in genetically diabetic miceQ44631836
Hyperglycaemic conditions decrease cultured keratinocyte mobility: implications for impaired wound healing in patients with diabetesQ46418713
Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus.Q46464366
Effect of glycaemic control on apoptosis in diabetic woundsQ46563040
Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell typeQ47933679
Streptozotocin-Induced Diabetic Rat–Derived Bone Marrow Mesenchymal Stem Cells Have Impaired Abilities in Proliferation, Paracrine, Antiapoptosis, and Myogenic DifferentiationQ33690215
Impaired proliferation and increased L-lactate production of dermal fibroblasts in the GK-rat, a spontaneous model of non-insulin dependent diabetes mellitusQ33860908
Endothelial colony-forming cell role in neoangiogenesis and tissue repairQ33894705
Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetesQ33957444
Advanced glycosylation end products in tissue and the biochemical basis of diabetic complicationsQ34049428
Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patientsQ34140774
Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2Q34231577
Advanced glycation end products: sparking the development of diabetic vascular injuryQ34555042
Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcersQ34570690
Cellular and molecular basis of wound healing in diabetesQ34625159
Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healingQ34767334
Treatment of inflammatory diseases with mesenchymal stem cellsQ34987147
Tumor necrosis factor-alpha mediates diabetes-enhanced apoptosis of matrix-producing cells and impairs diabetic healingQ35088004
Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of tumor necrosis factor-alphaQ35088035
Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cellsQ35098397
The myofibroblast in wound healing and fibrocontractive diseasesQ35170446
Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1.Q35639741
Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing.Q35691580
Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expressionQ35745906
Role of forkhead transcription factors in diabetes-induced oxidative stressQ35791713
Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.Q35849515
Altered fibroblast proliferation and apoptosis in diabetic gingival woundsQ35866625
Mechanisms of macrophage activation in obesity-induced insulin resistanceQ36054814
Cutaneous stem cells and wound healingQ36426375
The molecular biology of chronic wounds and delayed healing in diabetesQ36499284
Inflammation and wound healing: the role of the macrophageQ36679987
Keratinocyte migration, proliferation, and differentiation in chronic ulcers from patients with diabetes and normal woundsQ36725187
Keratinocyte-fibroblast interactions in wound healingQ36792546
Activation of RAGE induces elevated O2- generation by mononuclear phagocytes in diabetesQ36870610
Diabetic foot ulcers--a comprehensive review.Q36938282
Chemokines and diabetic wound healingQ37021616
Macrophage activation by endogenous danger signalsQ37045743
Economic costs of diabetes in the U.S. In 2007.Q37097601
FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic ratsQ37141739
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectdiabetesQ12206
peptideQ172847
regulation of gene expressionQ411391
blood proteinsQ425056
wound healingQ1509074
tumor necrosis factorQ21173843
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)754802
P577publication date2013-01-20
P1433published inBioMed Research InternationalQ17509958
P1476titleAbnormal cell responses and role of TNF-α in impaired diabetic wound healing
P478volume2013

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cites work (P2860)
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Q34694774Association of TNF-α with impaired migration capacity of mesenchymal stem cells in patients with systemic lupus erythematosus.
Q35395038Biphasic presence of fibrocytes in a porcine hypertrophic scar model
Q91705517CTGF Loaded Electrospun Dual Porous Core-Shell Membrane For Diabetic Wound Healing
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Q35038634Dehydroabietic acid reverses TNF-α-induced the activation of FOXO1 and suppression of TGF-β1/Smad signaling in human adult dermal fibroblasts
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Q35137241Diabetes reduces mesenchymal stem cells in fracture healing through a TNFα-mediated mechanism
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Q57922260Evaluation of the Epithelial Barrier Function and Ileal Microbiome in an Established Necrotic Enteritis Challenge Model in Broiler Chickens
Q35543164FOXO1 differentially regulates both normal and diabetic wound healing
Q34359097FOXO1, TGF-β regulation and wound healing
Q33954420Gr-1+CD11b+ myeloid cells efficiently home to site of injury after intravenous administration and enhance diabetic wound healing by neoangiogenesis
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Q47381137α7-nAChR Activation Has an Opposite Effect on Healing of Covered and Uncovered Wounds

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