Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer

scientific article published in June 2001

Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOOD.V97.11.3466
P698PubMed publication ID11369638

P2093author name stringKaliński P
Kapsenberg ML
de Jong EC
Schuitemaker JH
Vieira PL
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)3466-3469
P577publication date2001-06-01
P1433published inBloodQ885070
P1476titleProstaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer
P478volume97

Reverse relations

cites work (P2860)
Q84099310Q84099310
Q44245789A clinical grade cocktail of cytokines and PGE2 results in uniform maturation of human monocyte-derived dendritic cells: implications for immunotherapy
Q43499769A mutant of Escherichia coli enterotoxin inducing a specific Thl-type of T cells to varicella-zoster vaccine enhances the production of IL-12 by IFNgamma-stimulated macrophages
Q44233660A new era for innate immunity
Q39338676A novel and simple method for generation of human dendritic cells from unfractionated peripheral blood mononuclear cells within 2 days: its application for induction of HIV-1-reactive CD4(+) T cells in the hu-PBL SCID mice
Q45119186A novel signaling pathway mediates the inhibition of CCL3/4 expression by prostaglandin E2.
Q35053422A role for inflammatory mediators in the induction of immunoregulatory B cells
Q35848222A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation
Q39853571Ability of mature dendritic cells to interact with regulatory T cells is imprinted during maturation
Q44776861Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2.
Q44024646Ambivalent effects of dendritic cells displaying prostaglandin E2‐induced indoleamine 2,3‐dioxygenase
Q34105959Anti-HER2 vaccines: new prospects for breast cancer therapy
Q42003336Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells
Q41944042CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC.
Q79150247CD30 antigen: not a physiological marker for TH2 cells but an important costimulator molecule in the regulation of the balance between TH1/TH2 response
Q35865581Cellular immunotherapy using dendritic cells against multiple myeloma
Q34132796Combined treatment with interleukin-12 and indomethacin promotes increased resistance in BALB/c mice with established Leishmania major infections
Q39234940Comparison of clinical grade type 1 polarized and standard matured dendritic cells for cancer immunotherapy
Q41440265Complement regulates TLR4-mediated inflammatory responses during intestinal ischemia reperfusion
Q35630534Controlling the Toll road to dendritic cell polarization
Q36448084Current state and perspectives of dendritic cell vaccination in cancer immunotherapy
Q44912942Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling.
Q93078777Cyclo-Oxygenase (COX) Inhibitors and Cardiovascular Risk: Are Non-Steroidal Anti-Inflammatory Drugs Really Anti-Inflammatory?
Q38520811Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin (deoxynivalenol) in vitro and in vivo
Q35212596Cyclooxygenase-2 regulates Th17 cell differentiation during allergic lung inflammation
Q47399887Deficient IL-12p70 secretion by dendritic cells based on IL12B promoter genotype
Q35826624Dendritic Cell-Induced Th1 and Th17 Cell Differentiation for Cancer Therapy
Q35812979Dendritic cell therapy for skin cancer
Q37259624Dendritic cell-based cancer vaccination: quo vadis?
Q37773259Dendritic cell-based vaccines for the therapy of experimental tumors
Q79967042Dendritic cells in cancer immunotherapy
Q41520681Dendritic cells in cancer immunotherapy: vaccines or autologous transplants?
Q37513871Dendritic cells in immunotherapy of established cancer: Roles of signals 1, 2, 3 and 4
Q83020708Dendritic cells matured by a prostaglandin E2-containing cocktail can produce high levels of IL-12p70 and are more mature and Th1-biased than dendritic cells treated with TNF-α or LPS
Q35077130Dendritic cells under the spell of prostaglandins
Q35146556Designing the optimal vaccine: the importance of cytokines and dendritic cells.
Q44385459Downregulation of interleukin-12p35 and upregulation of interleukin-12p40 mRNA expression in heart allografts by blood transfusion from granulocyte colony-stimulating factor-treated donors
Q57065138Effects of Jaw Periosteal Cells on Dendritic Cell Maturation
Q26778011Eicosanoid pathway in colorectal cancer: Recent updates
Q38672403Enhanced stimulation of human tumor-specific T cells by dendritic cells matured in the presence of interferon-γ and multiple toll-like receptor agonists.
Q38261273Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma.
Q34714672Epithelial crosstalk at the microbiota-mucosal interface.
Q37159089Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut.
Q40041237Epstein Barr virus Latent Membrane Protein-1 enhances dendritic cell therapy lymph node migration, activation, and IL-12 secretion
Q33347561Ex vivo recovery and activation of dysfunctional, anergic, monocyte-derived dendritic cells from patients with operable breast cancer: critical role of IFN-alpha
Q38148774Exploiting dendritic cells in the development of cancer vaccines
Q40668545Fibroblasts inhibit the production of interleukin-12p70 by murine dendritic cells
Q84639419Fibroblasts stimulated via HLA-II molecules produce prostaglandin E₂ and regulate cytokine production from helper T cells
Q53548271Fibroblasts support migration of monocyte-derived dendritic cells by secretion of PGE2 and MMP-1.
Q33804673Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly
Q36090933Functional diversity and plasticity of human dendritic cell subsets
Q78468297Fundamentals of host immune response against Brucella abortus: what the mouse model has revealed about control of infection
Q36269842Gene Expression Profile of Dendritic Cell-Tumor Cell Hybrids Determined by Microarrays and Its Implications for Cancer Immunotherapy
Q43140456Generation of functional blocking monoclonal antibodies against mouse interleukin-12 p40 homodimer and monomer
Q81947651Generation of functionally mature dendritic cells from elutriated monocytes using polyinosinic : polycytidylic acid and soluble CD40 ligand for clinical application
Q44684461Generation of mature dendritic cells fully capable of T helper type 1 polarization using OK-432 combined with prostaglandin E(2).
Q41957729Generation of stable Th1/CTL-, Th2-, and Th17-inducing human dendritic cells
Q41876317Harnessing dendritic cells to generate cancer vaccines
Q37700841Harnessing human dendritic cell subsets for medicine
Q34672927Helper Activity of Natural Killer Cells During the Dendritic Cell-mediated Induction of Melanoma-specific Cytotoxic T Cells
Q27485530Hepatitis C Virus Inhibits Cell Surface Expression of HLA-DR, Prevents Dendritic Cell Maturation, and Induces Interleukin-10 Production
Q51983885Histamine and prostaglandin E up-regulate the production of Th2-attracting chemokines (CCL17 and CCL22) and down-regulate IFN-gamma-induced CXCL10 production by immature human dendritic cells
Q28366668Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization
Q34453939How to Deal with Polarized Th2 Cells: Exploring the Achilles’ Heel
Q34142925Human metapneumovirus induces a profile of lung cytokines distinct from that of respiratory syncytial virus
Q34333969IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function.
Q83191176IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction — A comparative study of human clinical-applicable DC
Q36403560IL-18-induced CD83+CCR7+ NK helper cells
Q36375426IL‐23‐dependent IL‐17 drives Th1‐cell responses following Mycobacterium bovis BCG vaccination
Q38855600Identification of Toxoplasma gondii protein fractions induce immune response against melanoma in mice.
Q37420586Immune-checkpoint blockade and active immunotherapy for glioma
Q51610481Immunological properties and vaccine efficacy of murine dendritic cells simultaneously expressing melanoma-associated antigen and interleukin-12.
Q81809220Immunomodulatory properties of human serum immunoglobulin A: anti-inflammatory and pro-inflammatory activities in human monocytes and peripheral blood mononuclear cells
Q35852574Immunotherapy Using Dendritic Cells against Multiple Myeloma: How to Improve?
Q36243536Immunotherapy of cancer in 2012
Q36162929Immunotherapy of malignant brain tumors
Q90722007In Vitro Anti-Inflammatory and Immunomodulatory Activities of an Extract from the Roots of Bupleurum rotundifolium
Q90259996In vitro activation and maturation of human mononuclear phagocytes by stimulation with liposomes coated with a neoglycolipid containing α1-3, α1-6-mannotriose
Q44787644Increased release of IL-12p70 by monocytes after periodontal therapy
Q40346494Induction of antigen-specific CD8+ cytotoxic T cells by dendritic cells co-electroporated with a dsRNA analogue and tumor antigen mRNA.
Q36911452Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response
Q50328977Infective Larvae of Brugia malayi Induce Polarization of Host Macrophages that Helps in Immune Evasion
Q33734635Inhibition of Myeloid Differentiation Factor 88 Reduces Human and Mouse T-Cell Interleukin-17 and IFNγ Production and Ameliorates Experimental Autoimmune Encephalomyelitis Induced in Mice
Q35206890Innate and adaptive determinants of host susceptibility to medically important fungi
Q40349921Interferon-alpha2a is sufficient for promoting dendritic cell immunogenicity
Q43429531Interleukin (IL)-31 activates signal transducer and activator of transcription (STAT)-1, STAT-5 and extracellular signal-regulated kinase 1/2 and down-regulates IL-12p40 production in activated human macrophages
Q33565624Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma
Q34273913Interleukin-12p40 modulates human metapneumovirus-induced pulmonary disease in an acute mouse model of infection
Q61714881Interleukin-4 inhibits cyclo-oxygenase-2 expression and prostaglandin E production by human mature dendritic cells
Q52656382Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.
Q44968943Involvement of multiple P2Y receptors and signaling pathways in the action of adenine nucleotides diphosphates on human monocyte-derived dendritic cells
Q36025111Isolation and generation of human dendritic cells
Q35876990Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function
Q84899471Leukotriene C4 prevents the complete maturation of murine dendritic cells and modifies interleukin-12/interleukin-23 balance
Q28080521Lipid mediators are critical in resolving inflammation: a review of the emerging roles of eicosanoids in diabetes mellitus
Q36016330Lipopolysaccharide-Activated Dendritic Cells: “Exhausted” or Alert and Waiting?
Q34146882MIS416, a non-toxic microparticle adjuvant derived from Propionibacterium acnes comprising immunostimulatory muramyl dipeptide and bacterial DNA promotes cross-priming and Th1 immunity
Q41968893Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration.
Q58619973Maximizing dendritic cell migration in cancer immunotherapy
Q46977477Mechanisms of strain-dependent development of mast cells from mouse splenocytes
Q64996233Microenvironmental derived factors modulating dendritic cell function and vaccine efficacy: the effect of prostanoid receptor and nuclear receptor ligands.
Q34613996Mollaret meningitis may be caused by reactivation of latent cerebral toxoplasmosis
Q34916497Monocyte-derived DC maturation strategies and related pathways: a transcriptional view
Q43040011Monocyte-derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile
Q34757680Murine oviduct epithelial cell cytokine responses to Chlamydia muridarum infection include interleukin-12-p70 secretion
Q35839858Neonatal plasma polarizes TLR4-mediated cytokine responses towards low IL-12p70 and high IL-10 production via distinct factors
Q34124931PGE(2) transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells
Q90047227PGE2 Is Crucial for the Generation of FAST Whole- Tumor-Antigens Loaded Dendritic Cells Suitable for Immunotherapy in Glioblastoma
Q38050458Peripheral blood monocyte responses in periodontitis
Q46694189Plasma cytokine changes in relation to exercise intensity and muscle damage.
Q37735454Polarized dendritic cells as cancer vaccines: directing effector-type T cells to tumors
Q37857709Potential Clinical Applications for Human Pluripotent Stem Cell-Derived Blood Components
Q33735487Preoperative Serum IL-12p40 Is a Potential Predictor of Kasai Portoenterostomy Outcome in Infants with Biliary Atresia
Q51050849Primary Human Blood Dendritic Cells for Cancer Immunotherapy-Tailoring the Immune Response by Dendritic Cell Maturation
Q48219588Promoting the accumulation of tumor-specific T cells in tumor tissues by dendritic cell vaccines and chemokine-modulating agents.
Q89886586Prostaglandin E2 in a TLR3- and 7/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8+ T cells
Q54597829Prostaglandin E2 is a negative regulator on human plasmacytoid dendritic cells.
Q37859271Prostaglandin E2 modulates dendritic cell function during chlamydial genital infection
Q36948594Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion
Q64080037Pseudomonas aeruginosa biofilm is a potent inducer of phagocyte hyperinflammation
Q33771051Regulation of CD154-induced interleukin-12 production in synovial fluid macrophages
Q26849305Regulation of immune responses by prostaglandin E2
Q28388235Regulatory dendritic cells: there is more than just immune activation
Q36710729Respiratory Francisella tularensis live vaccine strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cells
Q92441659Role of Dendritic Cells in Exposing Latent HIV-1 for the Kill
Q34933694Role of Innate Immune Factors in the Adjuvant Activity of Monophosphoryl Lipid A
Q33865201Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
Q58843220Selective maturation of dendritic cells byNippostrongylus brasiliensis-secreted proteins drives Th2 immune responses
Q41945985Short-term cultured, interleukin-15 differentiated dendritic cells have potent immunostimulatory properties
Q58662838Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responses
Q52599699Soluble CD30: a biomarker for evaluating the clinical risk versus benefit of IFNbeta1A treatment in multiple sclerosis patients.
Q34238426Soluble mediators regulating immunity in early life
Q95310618T Cell Receptor Engineered Lymphocytes for Cancer Therapy
Q33666789T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma.
Q41915647Targeting Toll-like receptor 7/8 enhances uptake of apoptotic leukemic cells by monocyte-derived dendritic cells but interferes with subsequent cytokine-induced maturation
Q42830119The Candida Th17 response is dependent on mannan- and beta-glucan-induced prostaglandin E2.
Q98224235The Gut-liver Axis in Immune Remodeling: New insight into Liver Diseases
Q80843163The clinical grade maturation cocktail monophosphoryl lipid A plus IFNgamma generates monocyte-derived dendritic cells with the capacity to migrate and induce Th1 polarization
Q35210456The history, evolution, and clinical use of dendritic cell-based immunization strategies in the therapy of brain tumors
Q38957065The role of dendritic cells in cancer
Q54498522The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses
Q41786456The yin and yang of intestinal epithelial cells in controlling dendritic cell function
Q37533657Toward effective immunotherapy for the treatment of malignant brain tumors
Q34484042Translating tumor antigens into cancer vaccines
Q49092861Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4.
Q37993359Tumor associated regulatory dendritic cells
Q39982625Tumour-mediated disruption of dendritic cell function: inhibiting the MEK1/2-p44/42 axis restores IL-12 production and Th1-generation.
Q43196387Type 2 Bias of T cells expanded from the blood of melanoma patients switched to type 1 by IL-12p70 mRNA-transfected dendritic cells
Q61863501Type I IFNs differentially modulate IL-12p70 production by human dendritic cells depending on the maturation status of the cells and counteract IFN-γ-mediated signaling
Q42556100Using dendritic cell maturation and IL-12 producing capacity as markers of function: a cautionary tale
Q81354727[Active immunotherapy of prostate cancer with a focus on dendritic cells]
Q38071900mRNA: From a chemical blueprint for protein production to an off-the-shelf therapeutic.

Search more.